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Chemical composition and cytotoxic activity of essential oil from myrcia laruotteana fruits / Maria Elida A. Stefanello in The journal of essential oil research, Vol. 23 N° 5 (Septembre/Octobre 2011) 

Public ISBD [article]  in The journal of essential oil research > Vol. 23 N° 5 (Septembre/Octobre 2011) . - pp. 7-10 Titre : Chemical composition and cytotoxic activity of essential oil from myrcia laruotteana fruits Type de document : texte imprimé Auteurs : Maria Elida A. Stefanello, Auteur ; Dilamara Riva, Auteur ; Edésio L. Simionatto, Auteur Année de publication : 2012 Article en page(s) : pp. 7-10 Note générale : Génie Chimique Langues : Anglais (eng) Mots-clés : Myrcia  laruotteana  Myrtaceae  Essential  oil  composition  α-bisabolol  α-bisabolol  oxide  B  Antiproliferative  activity Index. décimale : 646 Résumé : The essential oil isolated by hydrodistillation from unripe fruits of Myrcia laruotteana Camb. (Myrtaceae) was analyzed by GC and CG/MS. Forty-four components were identified, representing around 83% of total oil. The major components were α-bisabolol (23.6%) and α-bisabolol oxide B (11.5%). The cytotoxicity of the oil and of a fraction rich in α-bisabolol was tested in vitro against U251 (glioma), UACC-62 (melanoma), MCF-7 (breast), NC1-ADR/RES (ovarian-resistant), 786.0 (kidney), NCI-H460 (lung), PC-3 (prostate), OVCAR-3 (ovarian), HT-29 (colon) and K562 (leukemia) human cancer cells and against VERO (no cancer cell). The oil exhibited antiproliferative activity against all cell lines (TGI < 100 μg/mL), with exception of NCI-H460 cell line (TGI > 125 μg/mL). The highest activity of the oil was observed against U251 (TGI 20.46 μg/mL), 786.0 (TGI 20.74 μg/mL), UACC-62 (TGI 26.98 μg/mL) and PC-3 (TGI 27.63 μg/mL) cell lines. The fraction rich in α-bisabol showed a similar activity profile. It was most active against OVCAR-3 (TGI 8.58 μg/mL) and 786.0 (TGI 8.74 μg/mL). DEWEY : 665 ISSN : 1041-2905 En ligne : http://www.tandfonline.com/doi/abs/10.1080/10412905.2011.9700473 [article] Chemical composition and cytotoxic activity of essential oil from myrcia laruotteana fruits [texte imprimé] / Maria Elida A. Stefanello, Auteur ; Dilamara Riva, Auteur ; Edésio L. Simionatto, Auteur . - 2012 . - pp. 7-10. Génie Chimique Langues : Anglais (eng) in The journal of essential oil research > Vol. 23 N° 5 (Septembre/Octobre 2011) . - pp. 7-10 Mots-clés : Myrcia  laruotteana  Myrtaceae  Essential  oil  composition  α-bisabolol  α-bisabolol  oxide  B  Antiproliferative  activity Index. décimale : 646 Résumé : The essential oil isolated by hydrodistillation from unripe fruits of Myrcia laruotteana Camb. (Myrtaceae) was analyzed by GC and CG/MS. Forty-four components were identified, representing around 83% of total oil. The major components were α-bisabolol (23.6%) and α-bisabolol oxide B (11.5%). The cytotoxicity of the oil and of a fraction rich in α-bisabolol was tested in vitro against U251 (glioma), UACC-62 (melanoma), MCF-7 (breast), NC1-ADR/RES (ovarian-resistant), 786.0 (kidney), NCI-H460 (lung), PC-3 (prostate), OVCAR-3 (ovarian), HT-29 (colon) and K562 (leukemia) human cancer cells and against VERO (no cancer cell). The oil exhibited antiproliferative activity against all cell lines (TGI < 100 μg/mL), with exception of NCI-H460 cell line (TGI > 125 μg/mL). The highest activity of the oil was observed against U251 (TGI 20.46 μg/mL), 786.0 (TGI 20.74 μg/mL), UACC-62 (TGI 26.98 μg/mL) and PC-3 (TGI 27.63 μg/mL) cell lines. The fraction rich in α-bisabol showed a similar activity profile. It was most active against OVCAR-3 (TGI 8.58 μg/mL) and 786.0 (TGI 8.74 μg/mL). DEWEY : 665 ISSN : 1041-2905 En ligne : http://www.tandfonline.com/doi/abs/10.1080/10412905.2011.9700473