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Chiral resolution of Ionic compounds by thin layer extraction / Ram Lavie in Industrial & engineering chemistry research, Vol. 50 N° 22 (Novembre 2011) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 50 N° 22 (Novembre 2011) . - pp. 12750-12756 Titre : Chiral resolution of Ionic compounds by thin layer extraction Type de document : texte imprimé Auteurs : Ram Lavie, Auteur Année de publication : 2012 Article en page(s) : pp. 12750-12756 Note générale : Chimie industrielle Langues : Anglais (eng) Mots-clés : Ionic  compounds Résumé : The increasing demand for enantiomer intermediates has attracted in recent years attention to liquid–liquid extraction as a scalable chiral resolution method. Thin layer extraction, a simple and effective form of liquid–liquid extraction that uses little extractant, promises economic utilization of the most selective chiral hosts. The role played by various parameters when applying thin layer extraction to the resolution of an ionic racemic mixture into its enantiomer components is analyzed. This analysis provides a critical insight that facilitates the design of a successful separation scheme. It transpires that, given a suitable host, certain conditions concerning the host concentration and the pH and rate of the feed and strip solutions must be balanced to obtain optimum enantioseparation or even to obtain any separation at all. A calculated example that is based on experimental data from the published literature indicates that a simple thin layer extractor, using a crown ether host, is capable of separating an ionic racemic mixture into substantially pure enantiomer products at a high yield. It appears that thin layer extraction has some promising features to become an interesting alternative for other extraction-based techniques. DEWEY : 660 ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie201596n [article] Chiral resolution of Ionic compounds by thin layer extraction [texte imprimé] / Ram Lavie, Auteur . - 2012 . - pp. 12750-12756. Chimie industrielle Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 50 N° 22 (Novembre 2011) . - pp. 12750-12756 Mots-clés : Ionic  compounds Résumé : The increasing demand for enantiomer intermediates has attracted in recent years attention to liquid–liquid extraction as a scalable chiral resolution method. Thin layer extraction, a simple and effective form of liquid–liquid extraction that uses little extractant, promises economic utilization of the most selective chiral hosts. The role played by various parameters when applying thin layer extraction to the resolution of an ionic racemic mixture into its enantiomer components is analyzed. This analysis provides a critical insight that facilitates the design of a successful separation scheme. It transpires that, given a suitable host, certain conditions concerning the host concentration and the pH and rate of the feed and strip solutions must be balanced to obtain optimum enantioseparation or even to obtain any separation at all. A calculated example that is based on experimental data from the published literature indicates that a simple thin layer extractor, using a crown ether host, is capable of separating an ionic racemic mixture into substantially pure enantiomer products at a high yield. It appears that thin layer extraction has some promising features to become an interesting alternative for other extraction-based techniques. DEWEY : 660 ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie201596n