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Continuous solventless extrusion process for producing sodium carboxymethyl starch suitable for disintegrant applications in solid dosage forms

Pratik N. Bhandari, Auteur ; Milford A. Hanna, Auteur |

Dans Industrial & engineering chemistry research (Vol. 50 N° 22, Novembre 2011)

Sodium carboxymethyl starch (CMS) was prepared using an extruder as a continuous solventless chemical reactor. The effects of NaOH, H2O, temperature, ethanol, sodium monochloro acetate (SMCA), sodium tripolyphosphate (STPP), citric acid, epichlo[...]

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