Continuous solventless extrusion process for producing sodium carboxymethyl starch suitable for disintegrant applications in solid dosage forms / Pratik N. Bhandari in Industrial & engineering chemistry research, Vol. 50 N° 22 (Novembre 2011)  

Public ISBD [article]  inIndustrial & engineering chemistry research > Vol. 50 N° 22 (Novembre 2011) . - pp. 12784-12789 Titre : Continuous solventless extrusion process for producing sodium carboxymethyl starch suitable for disintegrant applications in solid dosage forms Type de document : texte imprimé Auteurs : Pratik N. Bhandari, Auteur ; Milford A. Hanna, Auteur Année de publication : 2012 Article en page(s) : pp. 12784-12789 Note générale : Chimie industrielle Langues : Anglais (eng) Mots-clés : Extrusion Résumé : Sodium carboxymethyl starch (CMS) was prepared using an extruder as a continuous solventless chemical reactor. The effects of NaOH, H2O, temperature, ethanol, sodium monochloro acetate (SMCA), sodium tripolyphosphate (STPP), citric acid, epichlorohydrin, and screw configuration on the degree of substitution (DS) and swelling properties of CMS were studied. Using these factors, CMS with the DS required for pharmaceutical disintegrant applications (0.22-0.35) was prepared. By modifying the water/ethanol ratio in the formulations and avoiding excess gelatinization caused by use of NaOH solution, CMS with rapid swelling properties in an aqueous medium, essential for superdisintegrant applications in solid dosage forms, was obtained. Both corn and potato starches were used to prepare the CMS. The carboxymethyl starch, with rapid swelling properties, was characterized using Fourier-transform infrared spectroscopy and scanning electron microscopy. DEWEY : 660 ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=24745753 [article] Continuous solventless extrusion process for producing sodium carboxymethyl starch suitable for disintegrant applications in solid dosage forms [texte imprimé] / Pratik N. Bhandari, Auteur ; Milford A. Hanna, Auteur . - 2012 . - pp. 12784-12789. Chimie industrielle Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 50 N° 22 (Novembre 2011) . - pp. 12784-12789 Mots-clés : Extrusion Résumé : Sodium carboxymethyl starch (CMS) was prepared using an extruder as a continuous solventless chemical reactor. The effects of NaOH, H2O, temperature, ethanol, sodium monochloro acetate (SMCA), sodium tripolyphosphate (STPP), citric acid, epichlorohydrin, and screw configuration on the degree of substitution (DS) and swelling properties of CMS were studied. Using these factors, CMS with the DS required for pharmaceutical disintegrant applications (0.22-0.35) was prepared. By modifying the water/ethanol ratio in the formulations and avoiding excess gelatinization caused by use of NaOH solution, CMS with rapid swelling properties in an aqueous medium, essential for superdisintegrant applications in solid dosage forms, was obtained. Both corn and potato starches were used to prepare the CMS. The carboxymethyl starch, with rapid swelling properties, was characterized using Fourier-transform infrared spectroscopy and scanning electron microscopy. DEWEY : 660 ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=24745753

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