Preparation of 5 - fluorouracil / B - cyclodextrin complex intercalated in layered double hydroxide and the Controlled drug release properties / Lan Jin in Industrial & engineering chemistry research, Vol. 49 N° 22 (Novembre 2010)  

Public ISBD [article]  inIndustrial & engineering chemistry research > Vol. 49 N° 22 (Novembre 2010) . - pp. 11176–11181 Titre : Preparation of 5 - fluorouracil / B - cyclodextrin complex intercalated in layered double hydroxide and the Controlled drug release properties Type de document : texte imprimé Auteurs : Lan Jin, Auteur ; Qing Liu, Auteur ; Zhiyong Sun, Auteur Année de publication : 2011 Article en page(s) : pp. 11176–11181 Note générale : Chimie industrielle Langues : Anglais (eng) Mots-clés : Preparation Fluorouracil Cyclodextrin Hydroxide Résumé : Hydrophobic anticancer drug 5-fluorouracil (5-FU) has been included in the carboxymethyl modified β-cyclodextrin (CMCD), and the inclusion complex (5-FU/CMCD) was further intercalated into galleries of a zinc aluminum layered double hydroxide (ZnAl-LDH) by the ion-exchange method. Powder X-ray diffraction (XRD), Fourier transform infrared (FT-IR), and UV-vis spectroscopy indicate a successful intercalation of 5-FU/CMCD into the LDH gallery. The release behavior of 5-FU from drug/CMCD-LDH composite at different pH values was studied. It was found that 5-FU was released faster in pH 7.2 than in the acidic mediums (pH 4.8), and the released amount was higher. The introduction of CMCD into the LDH matrix could prolong the drug release time in comparison to that from LDH without CMCD, which can be attributed to the inclusion of 5-FU by the CMCD cavity. Studies on mathematical modeling of drug release show that the release of 5-FU from the drug/CMCD-LDH composite follows the Korsmeyer-Peppas equation very well at different pH values. The drug/CMCD inclusion complex intercalated LDH composite in this work provides a supramolecular formulation for controlled release behavior, which can be potentially applied for nonionic and hydrophobic drugs. DEWEY : 660 ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie100990z [article] Preparation of 5 - fluorouracil / B - cyclodextrin complex intercalated in layered double hydroxide and the Controlled drug release properties [texte imprimé] / Lan Jin, Auteur ; Qing Liu, Auteur ; Zhiyong Sun, Auteur . - 2011 . - pp. 11176–11181. Chimie industrielle Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 49 N° 22 (Novembre 2010) . - pp. 11176–11181 Mots-clés : Preparation Fluorouracil Cyclodextrin Hydroxide Résumé : Hydrophobic anticancer drug 5-fluorouracil (5-FU) has been included in the carboxymethyl modified β-cyclodextrin (CMCD), and the inclusion complex (5-FU/CMCD) was further intercalated into galleries of a zinc aluminum layered double hydroxide (ZnAl-LDH) by the ion-exchange method. Powder X-ray diffraction (XRD), Fourier transform infrared (FT-IR), and UV-vis spectroscopy indicate a successful intercalation of 5-FU/CMCD into the LDH gallery. The release behavior of 5-FU from drug/CMCD-LDH composite at different pH values was studied. It was found that 5-FU was released faster in pH 7.2 than in the acidic mediums (pH 4.8), and the released amount was higher. The introduction of CMCD into the LDH matrix could prolong the drug release time in comparison to that from LDH without CMCD, which can be attributed to the inclusion of 5-FU by the CMCD cavity. Studies on mathematical modeling of drug release show that the release of 5-FU from the drug/CMCD-LDH composite follows the Korsmeyer-Peppas equation very well at different pH values. The drug/CMCD inclusion complex intercalated LDH composite in this work provides a supramolecular formulation for controlled release behavior, which can be potentially applied for nonionic and hydrophobic drugs. DEWEY : 660 ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie100990z

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Synthesis and controlled release properties of prednisone intercalated Mg−Al layered double hydroxide composite / Fusu Li in Industrial & engineering chemistry research, Vol. 48 N° 12 (Juin 2009)  

Public ISBD [article]  inIndustrial & engineering chemistry research > Vol. 48 N° 12 (Juin 2009) . - pp. 5590–5597 Titre : Synthesis and controlled release properties of prednisone intercalated Mg−Al layered double hydroxide composite Type de document : texte imprimé Auteurs : Fusu Li, Auteur ; Lan Jin, Auteur ; Jingbin Han, Auteur Année de publication : 2009 Article en page(s) : pp. 5590–5597 Note générale : Chemical engineering Langues : Anglais (eng) Mots-clés : Drug-inorganic composite Prednisone-cholate ion micelles Mg-Al layered double hydroxide X-ray diffraction Fourier transform infrared UV-vis absorption spectroscopy Résumé : A drug−inorganic composite involving prednisone−cholate ion micelles intercalated Mg−Al layered double hydroxide (LDH) has been assembled by a coprecipitation method. Powder X-ray diffraction (XRD), Fourier transform infrared (FT-IR), and UV−vis absorption spectroscopy indicate a successful intercalation of prednisone-containing micelles into galleries of the LDH matrix. The in vitro drug release studies show that no burst release phenomenon was observed at the beginning of release tests, and the pH value imposes very little influence on the release performance of prednisone in the studied pH range 4.8−7.6. It is, therefore, concluded that the MgAl-LDH can be used as an excellent inorganic drug carrier for prednisone in a wide range of pH values. Four kinetic models (first-order equation, Higuchi equation, Bhaskas equation, and Ritger−Peppas equation) were chosen to study the release kinetics of prednisone from the LDH carrier, and it was found that this process can be described by the Ritger−Peppas equation satisfactorily based on a directing Excel-based solver (DEBS). Moreover, the mechanism for drug release was also discussed. En ligne : http://pubs.acs.org/doi/abs/10.1021/ie900043r [article] Synthesis and controlled release properties of prednisone intercalated Mg−Al layered double hydroxide composite [texte imprimé] / Fusu Li, Auteur ; Lan Jin, Auteur ; Jingbin Han, Auteur . - 2009 . - pp. 5590–5597. Chemical engineering Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 48 N° 12 (Juin 2009) . - pp. 5590–5597 Mots-clés : Drug-inorganic composite Prednisone-cholate ion micelles Mg-Al layered double hydroxide X-ray diffraction Fourier transform infrared UV-vis absorption spectroscopy Résumé : A drug−inorganic composite involving prednisone−cholate ion micelles intercalated Mg−Al layered double hydroxide (LDH) has been assembled by a coprecipitation method. Powder X-ray diffraction (XRD), Fourier transform infrared (FT-IR), and UV−vis absorption spectroscopy indicate a successful intercalation of prednisone-containing micelles into galleries of the LDH matrix. The in vitro drug release studies show that no burst release phenomenon was observed at the beginning of release tests, and the pH value imposes very little influence on the release performance of prednisone in the studied pH range 4.8−7.6. It is, therefore, concluded that the MgAl-LDH can be used as an excellent inorganic drug carrier for prednisone in a wide range of pH values. Four kinetic models (first-order equation, Higuchi equation, Bhaskas equation, and Ritger−Peppas equation) were chosen to study the release kinetics of prednisone from the LDH carrier, and it was found that this process can be described by the Ritger−Peppas equation satisfactorily based on a directing Excel-based solver (DEBS). Moreover, the mechanism for drug release was also discussed. En ligne : http://pubs.acs.org/doi/abs/10.1021/ie900043r

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