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Effect of alkyl derivatization on several properties of N-halamine antimicrobial siloxane coatings / Hasan B. Kocer in Industrial & engineering chemistry research, Vol. 47 N°20 (Octobre 2008) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 47 N°20 (Octobre 2008) . - P. 7558-7563 Titre : Effect of alkyl derivatization on several properties of N-halamine antimicrobial siloxane coatings Type de document : texte imprimé Auteurs : Hasan B. Kocer, Editeur scientifique ; Akin Akdag, Editeur scientifique ; Xuehong Ren, Editeur scientifique Année de publication : 2008 Article en page(s) : P. 7558-7563 Note générale : Chemical engineering Langues : Anglais (eng) Mots-clés : Alkyl  derivatization  N-Halamine  Antimicrobial Résumé : Variation of alkyl substitution at position 5 on the hydantoin ring of a series of N-halamine siloxane derivatives has been employed to better understand the biocidal activities of these compounds for use in preparing antimicrobial coatings. The alkyl derivatization of the hydantoin ring at its 5 position, while an essentially constant chlorine loading is maintained at the 1 position, has shown that there is little dependence of the antimicrobial efficacy against Escherichia coli O157:H7 on the alkyl chain length, in contrast to reported observations for biocidal quaternary ammonium salt derivatives. The stabilities of the derivatives toward hydrolyses and ultraviolet light exposure have also been found to not be dependent upon the nature of the alkyl substituent group. These observations led to the conclusion that the 5,5-dimethyl derivative would be recommended for use, since it is the least expensive alternative. En ligne : http://pubs.acs.org/doi/abs/10.1021/ie800899u [article] Effect of alkyl derivatization on several properties of N-halamine antimicrobial siloxane coatings [texte imprimé] / Hasan B. Kocer, Editeur scientifique ; Akin Akdag, Editeur scientifique ; Xuehong Ren, Editeur scientifique . - 2008 . - P. 7558-7563. Chemical engineering Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 47 N°20 (Octobre 2008) . - P. 7558-7563 Mots-clés : Alkyl  derivatization  N-Halamine  Antimicrobial Résumé : Variation of alkyl substitution at position 5 on the hydantoin ring of a series of N-halamine siloxane derivatives has been employed to better understand the biocidal activities of these compounds for use in preparing antimicrobial coatings. The alkyl derivatization of the hydantoin ring at its 5 position, while an essentially constant chlorine loading is maintained at the 1 position, has shown that there is little dependence of the antimicrobial efficacy against Escherichia coli O157:H7 on the alkyl chain length, in contrast to reported observations for biocidal quaternary ammonium salt derivatives. The stabilities of the derivatives toward hydrolyses and ultraviolet light exposure have also been found to not be dependent upon the nature of the alkyl substituent group. These observations led to the conclusion that the 5,5-dimethyl derivative would be recommended for use, since it is the least expensive alternative. En ligne : http://pubs.acs.org/doi/abs/10.1021/ie800899u

Effect of phenyl derivatization on the stabilities of antimicrobial N - chlorohydantoin derivatives / Hasan B. Kocer in Industrial & engineering chemistry research, Vol. 49 N° 22 (Novembre 2010) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 49 N° 22 (Novembre 2010) . - pp. 11188–11194 Titre : Effect of phenyl derivatization on the stabilities of antimicrobial N - chlorohydantoin derivatives Type de document : texte imprimé Auteurs : Hasan B. Kocer, Auteur ; S. D. Worley, Auteur ; R. M. Broughton, Auteur Année de publication : 2011 Article en page(s) : pp. 11188–11194 Note générale : Chimie industrielle Langues : Anglais (eng) Mots-clés : Antimicrobial Résumé : Phenyl substitution at position 5 on the hydantoin ring of a series of N-halamine derivatives, including an antimicrobial siloxane used for coating surfaces, has been employed to better understand the biocidal activities and stabilities of these compounds in the presence of water and exposure to ultraviolet irradiation. This phenyl derivatization of the hydantoin ring at its 5 position does, in fact, affect the antimicrobial efficacy of the siloxane against Staphylococcus aureus and Escherichia coli O157:H7, and its stability toward hydrolyses and ultraviolet light exposure. The phenyl substitution caused weakening of the N−Cl bond at the 1 position on the hydantoin ring, leading to an increase in biocidal activity but a decrease in stability. Model compounds were studied experimentally and theoretically at the (U)B3LYP/6-311++G(2d,p) level of theory in order to better explain the observations. It was found that the phenyl moiety at position 5 on the hydantoin ring can interact with the oxidative chlorine atom bonded to the amide nitrogen atom at position 1 which then results in a less stable N−Cl bond. DEWEY : 660 ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie101258s [article] Effect of phenyl derivatization on the stabilities of antimicrobial N - chlorohydantoin derivatives [texte imprimé] / Hasan B. Kocer, Auteur ; S. D. Worley, Auteur ; R. M. Broughton, Auteur . - 2011 . - pp. 11188–11194. Chimie industrielle Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 49 N° 22 (Novembre 2010) . - pp. 11188–11194 Mots-clés : Antimicrobial Résumé : Phenyl substitution at position 5 on the hydantoin ring of a series of N-halamine derivatives, including an antimicrobial siloxane used for coating surfaces, has been employed to better understand the biocidal activities and stabilities of these compounds in the presence of water and exposure to ultraviolet irradiation. This phenyl derivatization of the hydantoin ring at its 5 position does, in fact, affect the antimicrobial efficacy of the siloxane against Staphylococcus aureus and Escherichia coli O157:H7, and its stability toward hydrolyses and ultraviolet light exposure. The phenyl substitution caused weakening of the N−Cl bond at the 1 position on the hydantoin ring, leading to an increase in biocidal activity but a decrease in stability. Model compounds were studied experimentally and theoretically at the (U)B3LYP/6-311++G(2d,p) level of theory in order to better explain the observations. It was found that the phenyl moiety at position 5 on the hydantoin ring can interact with the oxidative chlorine atom bonded to the amide nitrogen atom at position 1 which then results in a less stable N−Cl bond. DEWEY : 660 ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie101258s