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Anti-inflammatory and antioxidant activity of a methanolic extract of phyllanthus orbicularis and its derived flavonols / Yamilet Irene Gutiérrez Gaitén in The journal of essential oil research, Vol. 23 N° 5 (Septembre/Octobre 2011) 

Public ISBD [article]  in The journal of essential oil research > Vol. 23 N° 5 (Septembre/Octobre 2011) . - pp. 50-53 Titre : Anti-inflammatory and antioxidant activity of a methanolic extract of phyllanthus orbicularis and its derived flavonols Type de document : texte imprimé Auteurs : Yamilet Irene Gutiérrez Gaitén, Auteur ; Migdalia Miranda Martínez, Auteur ; Adonis Bello Alarcón, Auteur Année de publication : 2012 Article en page(s) : pp. 50-53 Note générale : Génie Chimique Langues : Anglais (eng) Mots-clés : Phyllanthus  orbicularis  Leaf  and  steam  extracts  Flavonoids  Anti-inflammatory  activity  Antioxidant  activity Index. décimale : 646 Résumé : In order to validate the use of Phyllanthus orbicularis (Phyllantaceae) in the traditional medicine of Cuba as an anti-inflammatory remedy, the methanolic (MeOH) extract has been evaluated in vivo for anti-inflammatory activity on 12-O-tetradecanoyl-13-acetate phrobol (TPA) assay in mouse and in vitro for the antioxidant activity on Ferric Reduction Antioxidant Power assay. This extract exerted in vivo a significant anti-inflammatory activity. Subsequent fractionation and analysis of the extract has led to the isolation and characterization as major constituents of apigenin (1), rutin (quercetin 3-O—L-rhamnopyranosyl-(1->6)—D-glucopyranoside) (2) and quercetin (3) and of rutin decaacetate (4) and quercetin pentaacetate (5) from acetylated methanolic extract. Their structures were elucidated by spectral methods. The bioassay-directed analysis of flavonols 1–3 indicated that rutin (2) and quercetin (3) were the most active compounds, whereas apigenin showed no significant activity. The acetylation process increased the anti-inflammatory activity but decreased the antioxidant activity. The MeOH extract and all of flavonoids tested did not show in vitro significant cytotoxic effect in J774.A1 macrophage cell line. [Editor's note: The five compounds under discussion are denoted throughout this paper by bolded number (1, 2, etc.). This should not be confused with the referenced ancillary texts, denoted in non-bolded font and within parentheses.] DEWEY : 665 ISSN : 1041-2905 En ligne : http://www.tandfonline.com/doi/abs/10.1080/10412905.2011.9700482 [article] Anti-inflammatory and antioxidant activity of a methanolic extract of phyllanthus orbicularis and its derived flavonols [texte imprimé] / Yamilet Irene Gutiérrez Gaitén, Auteur ; Migdalia Miranda Martínez, Auteur ; Adonis Bello Alarcón, Auteur . - 2012 . - pp. 50-53. Génie Chimique Langues : Anglais (eng) in The journal of essential oil research > Vol. 23 N° 5 (Septembre/Octobre 2011) . - pp. 50-53 Mots-clés : Phyllanthus  orbicularis  Leaf  and  steam  extracts  Flavonoids  Anti-inflammatory  activity  Antioxidant  activity Index. décimale : 646 Résumé : In order to validate the use of Phyllanthus orbicularis (Phyllantaceae) in the traditional medicine of Cuba as an anti-inflammatory remedy, the methanolic (MeOH) extract has been evaluated in vivo for anti-inflammatory activity on 12-O-tetradecanoyl-13-acetate phrobol (TPA) assay in mouse and in vitro for the antioxidant activity on Ferric Reduction Antioxidant Power assay. This extract exerted in vivo a significant anti-inflammatory activity. Subsequent fractionation and analysis of the extract has led to the isolation and characterization as major constituents of apigenin (1), rutin (quercetin 3-O—L-rhamnopyranosyl-(1->6)—D-glucopyranoside) (2) and quercetin (3) and of rutin decaacetate (4) and quercetin pentaacetate (5) from acetylated methanolic extract. Their structures were elucidated by spectral methods. The bioassay-directed analysis of flavonols 1–3 indicated that rutin (2) and quercetin (3) were the most active compounds, whereas apigenin showed no significant activity. The acetylation process increased the anti-inflammatory activity but decreased the antioxidant activity. The MeOH extract and all of flavonoids tested did not show in vitro significant cytotoxic effect in J774.A1 macrophage cell line. [Editor's note: The five compounds under discussion are denoted throughout this paper by bolded number (1, 2, etc.). This should not be confused with the referenced ancillary texts, denoted in non-bolded font and within parentheses.] DEWEY : 665 ISSN : 1041-2905 En ligne : http://www.tandfonline.com/doi/abs/10.1080/10412905.2011.9700482