Kinetic mechanisms of cholesterol synthesis / Tapobrata Panda in Industrial & engineering chemistry research, Vol. 50 N° 23 (Décembre 2011)  

Public ISBD [article]  inIndustrial & engineering chemistry research > Vol. 50 N° 23 (Décembre 2011) . - pp. 12847-12864 Titre : Kinetic mechanisms of cholesterol synthesis : a review Type de document : texte imprimé Auteurs : Tapobrata Panda, Auteur ; Tanmay Basak, Auteur ; Ganesan Saraswathi, Auteur Année de publication : 2012 Article en page(s) : pp. 12847-12864 Note générale : Chimie industrielle Langues : Anglais (eng) Mots-clés : Kinetics Résumé : Increased levels of cholesterol lead to critical health risk factors such as hypercholesterolemia and atherosclerosis in the human system. Regulation of cholesterol synthesis in mammals, especially in humans, is required for a healthy lifestyle. Cholesterol synthesis from acetyl Co-A in liver involves more than 10 enzymes, beginning with acetoacetyl Co-A thiolase, to desmosterol reductase. Among these, 3-hydroxy-3-methylglutaryl-Coenzyme A reductase (HMGR) could be involved in the rate-determining step of cholesterol synthesis. Statins are used to control HMGR. Because statins possess many side effects, an alternate drug for hypercholesterolemia with minimum or no side effects is in great demand. The first and foremost step in drug design is to select a suitable drug target, most likely an enzyme inhibitor. In this regard, an in-depth study of the kinetics of the enzymes involved in cholesterol synthesis is required for a preferred drug target, which, in turn, requires a thorough knowledge of the mechanisms involved in each step of cholesterol synthesis. This communication gives an overview of the mechanisms and kinetics of the key enzymatic reactions involved in the cholesterol synthesis pathway in different organisms. DEWEY : 660 ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=25267443 [article] Kinetic mechanisms of cholesterol synthesis : a review [texte imprimé] / Tapobrata Panda, Auteur ; Tanmay Basak, Auteur ; Ganesan Saraswathi, Auteur . - 2012 . - pp. 12847-12864. Chimie industrielle Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 50 N° 23 (Décembre 2011) . - pp. 12847-12864 Mots-clés : Kinetics Résumé : Increased levels of cholesterol lead to critical health risk factors such as hypercholesterolemia and atherosclerosis in the human system. Regulation of cholesterol synthesis in mammals, especially in humans, is required for a healthy lifestyle. Cholesterol synthesis from acetyl Co-A in liver involves more than 10 enzymes, beginning with acetoacetyl Co-A thiolase, to desmosterol reductase. Among these, 3-hydroxy-3-methylglutaryl-Coenzyme A reductase (HMGR) could be involved in the rate-determining step of cholesterol synthesis. Statins are used to control HMGR. Because statins possess many side effects, an alternate drug for hypercholesterolemia with minimum or no side effects is in great demand. The first and foremost step in drug design is to select a suitable drug target, most likely an enzyme inhibitor. In this regard, an in-depth study of the kinetics of the enzymes involved in cholesterol synthesis is required for a preferred drug target, which, in turn, requires a thorough knowledge of the mechanisms involved in each step of cholesterol synthesis. This communication gives an overview of the mechanisms and kinetics of the key enzymatic reactions involved in the cholesterol synthesis pathway in different organisms. DEWEY : 660 ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=25267443

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