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Preparation and characterization of inclusion complexes of β-cyclodextrin−BITC and β-cyclodextrin−PEITC / Hai-Na Yuan in Industrial & engineering chemistry research, Vol. 48 N° 10 (Mai 2009) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 48 N° 10 (Mai 2009) . - pp. 5070–5078 Titre : Preparation and characterization of inclusion complexes of β-cyclodextrin−BITC and β-cyclodextrin−PEITC Type de document : texte imprimé Auteurs : Hai-Na Yuan, Auteur ; Shan-Jing Yao, Auteur ; Lian-Qing Shen, Auteur Année de publication : 2009 Article en page(s) : pp. 5070–5078 Note générale : Chemical engineering Langues : Anglais (eng) Mots-clés : Benzyl  isothiocyanate  Phenylethyl  isothiocyanate  Inclusion  complexes  Response  surface  design Résumé : Benzyl isothiocyanate (BITC) and phenylethyl isothiocyanate (PEITC) are two poorly water-soluble plant components that can form inclusion complexes with β-cyclodextrin (β-CD), namely, β-cyclodextrin−BITC and β-cyclodextrin−PEITC, that are two water-soluble complexes. The inclusion complexes were prepared by two independent processes: physical mixing and coprecipitation. The content of guest molecules in the complexes was measured by UV spectrophotometry. Response surface design (RSD) was applied to optimize the preparation conditions of said complexes. The results showed that the embedding ratios for β-CD−BITC and β-CD−PEITC were 94.9% and 94.1%, respectively. Variance analysis revealed that the mass ratio and the inclusion temperature were two important factors in terms of inclusion action. The optimum conditions for the inclusion of β-CD−BITC were a mass ratio of 0.17 and an inclusion temperature of 57.99 °C, and those for β-CD−PEITC were a mass ratio of 0.0057 and an inclusion temperature of 64.87 °C. The inclusion complexes prepared were qualified by thermal methods [thermogravimetry (TG) and differential scanning calorimetry (DSC)], Fourier transform infrared (FTIR) spectroscopy, and X-ray powder diffraction (XRD). The thermal analysis of β-CD and the two complexes indicated that an interaction between the guest and host molecules did occur. BITC and PEITC could be partially embedded in the hydrophobic cavity of β-CD, so the formation of the said complexes was established. The X-ray and FTIR results support this indication of inclusion behavior. En ligne : http://pubs.acs.org/doi/abs/10.1021/ie8015329 [article] Preparation and characterization of inclusion complexes of β-cyclodextrin−BITC and β-cyclodextrin−PEITC [texte imprimé] / Hai-Na Yuan, Auteur ; Shan-Jing Yao, Auteur ; Lian-Qing Shen, Auteur . - 2009 . - pp. 5070–5078. Chemical engineering Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 48 N° 10 (Mai 2009) . - pp. 5070–5078 Mots-clés : Benzyl  isothiocyanate  Phenylethyl  isothiocyanate  Inclusion  complexes  Response  surface  design Résumé : Benzyl isothiocyanate (BITC) and phenylethyl isothiocyanate (PEITC) are two poorly water-soluble plant components that can form inclusion complexes with β-cyclodextrin (β-CD), namely, β-cyclodextrin−BITC and β-cyclodextrin−PEITC, that are two water-soluble complexes. The inclusion complexes were prepared by two independent processes: physical mixing and coprecipitation. The content of guest molecules in the complexes was measured by UV spectrophotometry. Response surface design (RSD) was applied to optimize the preparation conditions of said complexes. The results showed that the embedding ratios for β-CD−BITC and β-CD−PEITC were 94.9% and 94.1%, respectively. Variance analysis revealed that the mass ratio and the inclusion temperature were two important factors in terms of inclusion action. The optimum conditions for the inclusion of β-CD−BITC were a mass ratio of 0.17 and an inclusion temperature of 57.99 °C, and those for β-CD−PEITC were a mass ratio of 0.0057 and an inclusion temperature of 64.87 °C. The inclusion complexes prepared were qualified by thermal methods [thermogravimetry (TG) and differential scanning calorimetry (DSC)], Fourier transform infrared (FTIR) spectroscopy, and X-ray powder diffraction (XRD). The thermal analysis of β-CD and the two complexes indicated that an interaction between the guest and host molecules did occur. BITC and PEITC could be partially embedded in the hydrophobic cavity of β-CD, so the formation of the said complexes was established. The X-ray and FTIR results support this indication of inclusion behavior. En ligne : http://pubs.acs.org/doi/abs/10.1021/ie8015329

Preparation of roxithromycin - loaded poly (l - lactic acid) films with supercritical solution impregnation / Jin-Peng Yu in Industrial & engineering chemistry research, Vol. 50 N° 24 (Décembre 2011) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 50 N° 24 (Décembre 2011) . - pp. 13813–13818 Titre : Preparation of roxithromycin - loaded poly (l - lactic acid) films with supercritical solution impregnation Type de document : texte imprimé Auteurs : Jin-Peng Yu, Auteur ; Yi-Xin Guan, Auteur ; Shan-Jing Yao, Auteur Année de publication : 2012 Article en page(s) : pp. 13813–13818 Note générale : Chimie industrielle Langues : Anglais (eng) Mots-clés : Roxithromycin Résumé : Supercritical solution impregnation (SSI) was applied to prepare drug-loaded biodegradable films where poly(l-lactic acid) (PLLA) was used as the matrix and roxithromycin as the model drug. The effects of impregnation time, operating temperature, and pressure on drug loading capacity (DLC) of roxithromycin into PLLA matrix were investigated. With the extension of impregnation time, DLC increased gradually to an equilibrium value. DLC was also affected by impregnation temperature and pressure. At the optimal condition, i.e., impregnating at 70 °C and 300 bar for 2 h, the maximal DLC was approximately 10.5%. After SSI process, the PLLA film was still transparent. The SEM images showed that the morphologies of PLLA film did not change with the SSI process. The DSC data and XRD spectra demonstrated that roxithromycin molecules were dispersed into the PLLA film in an amorphous state and the SCCO2 processed PLLA film had a lower crystal degree than raw PLLA film. The residual dichloromethane due to the PLLA film preparation could be removed effectively during the SSI process and meet the Chinese Pharmacopoeia limit. In vitro release of roxithromycin consisted of two stages: initial rapid release and a following slow release. The SSI process is expected to be a promising technique to prepare a drug-loaded biodegradable polymer surface and matrix for antibacterial therapeutic implants. DEWEY : 660 ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie201294u [article] Preparation of roxithromycin - loaded poly (l - lactic acid) films with supercritical solution impregnation [texte imprimé] / Jin-Peng Yu, Auteur ; Yi-Xin Guan, Auteur ; Shan-Jing Yao, Auteur . - 2012 . - pp. 13813–13818. Chimie industrielle Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 50 N° 24 (Décembre 2011) . - pp. 13813–13818 Mots-clés : Roxithromycin Résumé : Supercritical solution impregnation (SSI) was applied to prepare drug-loaded biodegradable films where poly(l-lactic acid) (PLLA) was used as the matrix and roxithromycin as the model drug. The effects of impregnation time, operating temperature, and pressure on drug loading capacity (DLC) of roxithromycin into PLLA matrix were investigated. With the extension of impregnation time, DLC increased gradually to an equilibrium value. DLC was also affected by impregnation temperature and pressure. At the optimal condition, i.e., impregnating at 70 °C and 300 bar for 2 h, the maximal DLC was approximately 10.5%. After SSI process, the PLLA film was still transparent. The SEM images showed that the morphologies of PLLA film did not change with the SSI process. The DSC data and XRD spectra demonstrated that roxithromycin molecules were dispersed into the PLLA film in an amorphous state and the SCCO2 processed PLLA film had a lower crystal degree than raw PLLA film. The residual dichloromethane due to the PLLA film preparation could be removed effectively during the SSI process and meet the Chinese Pharmacopoeia limit. In vitro release of roxithromycin consisted of two stages: initial rapid release and a following slow release. The SSI process is expected to be a promising technique to prepare a drug-loaded biodegradable polymer surface and matrix for antibacterial therapeutic implants. DEWEY : 660 ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie201294u