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Instantaneous and overall indicators for determination of bottleneck ranking in metabolic reaction networks / Kansuporn Sriyudthsak in Industrial & engineering chemistry research, Vol. 49 N° 5 (Mars 2010) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 49 N° 5 (Mars 2010) . - pp. 2122–2129 Titre : Instantaneous and overall indicators for determination of bottleneck ranking in metabolic reaction networks Type de document : texte imprimé Auteurs : Kansuporn Sriyudthsak, Auteur ; Fumihide Shiraishi, Auteur Année de publication : 2010 Article en page(s) : pp. 2122–2129 Note générale : Industrial Chemistry Langues : Anglais (eng) Mots-clés : Metabolic  Reaction  Networks Résumé : A dynamic logarithmic gain expresses the percentage change in a dependent variable or metabolite concentration in response to an infinitesimal percentage change in an independent variable or enzyme activity. This article discusses the usefulness of several bottleneck ranking (BR) indicators that are functions of the logarithmic gain, to determine the most likely bottleneck enzyme in a dynamic metabolic reaction system. Mathematical models for penicillin V and ethanol fermentations are considered as case studies. The calculated results reveal that the instantaneous BR indicator, which is a product of the dynamic logarithmic gain and the metabolite concentration, is an effective measure for instantaneous bottleneck enzyme ranking changed during the fermentation period, whereas the overall BR indicator, which is a time-averaged value of the instantaneous BR indicator, is an effective measure for bottleneck enzyme ranking throughout the entire fermentation period. Note de contenu : Bibliogr. ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie901531d [article] Instantaneous and overall indicators for determination of bottleneck ranking in metabolic reaction networks [texte imprimé] / Kansuporn Sriyudthsak, Auteur ; Fumihide Shiraishi, Auteur . - 2010 . - pp. 2122–2129. Industrial Chemistry Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 49 N° 5 (Mars 2010) . - pp. 2122–2129 Mots-clés : Metabolic  Reaction  Networks Résumé : A dynamic logarithmic gain expresses the percentage change in a dependent variable or metabolite concentration in response to an infinitesimal percentage change in an independent variable or enzyme activity. This article discusses the usefulness of several bottleneck ranking (BR) indicators that are functions of the logarithmic gain, to determine the most likely bottleneck enzyme in a dynamic metabolic reaction system. Mathematical models for penicillin V and ethanol fermentations are considered as case studies. The calculated results reveal that the instantaneous BR indicator, which is a product of the dynamic logarithmic gain and the metabolite concentration, is an effective measure for instantaneous bottleneck enzyme ranking changed during the fermentation period, whereas the overall BR indicator, which is a time-averaged value of the instantaneous BR indicator, is an effective measure for bottleneck enzyme ranking throughout the entire fermentation period. Note de contenu : Bibliogr. ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie901531d

Selection of best indicators for ranking and determination of bottleneck enzymes in metabolic reaction systems / Kansuporn Sriyudthsak in Industrial & engineering chemistry research, Vol. 49 N° 20 (Octobre 2010) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 49 N° 20 (Octobre 2010) . - pp. 9738–9742 Titre : Selection of best indicators for ranking and determination of bottleneck enzymes in metabolic reaction systems Type de document : texte imprimé Auteurs : Kansuporn Sriyudthsak, Auteur ; Fumihide Shiraishi, Auteur Année de publication : 2011 Article en page(s) : pp. 9738–9742 Note générale : Chimie industrielle Langues : Anglais (eng) Mots-clés : Enzymes  Metabolic  reaction Résumé : Dynamic logarithmic gain and its modifications can be theoretically used as a bottleneck ranking (BR) indicator in a metabolic reaction system. However, it is not sufficiently explicit whether they can be successfully used in practical applications. The present work therefore focuses on the selection of best BR indicators in both instantaneous and overall cases. A modified ethanol fermentation model is used as a case study. The results indicate that the mathematical product of dynamic logarithmic gain and desired product concentration at a given time is the best instantaneous BR indicator, whereas its value at the end time of the fermentation process is the best overall BR indicator. The former is useful for observing the time course of the desired product concentration and determining a process time to be terminated. The latter is for ranking bottleneck enzymes to determine which enzyme activity should be changed to attain a higher desired product concentration. Moreover, discussion is made on the utilization of the overall BR indicators to predict how much the final desired product concentration is increased. DEWEY : 660 ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie100911h [article] Selection of best indicators for ranking and determination of bottleneck enzymes in metabolic reaction systems [texte imprimé] / Kansuporn Sriyudthsak, Auteur ; Fumihide Shiraishi, Auteur . - 2011 . - pp. 9738–9742. Chimie industrielle Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 49 N° 20 (Octobre 2010) . - pp. 9738–9742 Mots-clés : Enzymes  Metabolic  reaction Résumé : Dynamic logarithmic gain and its modifications can be theoretically used as a bottleneck ranking (BR) indicator in a metabolic reaction system. However, it is not sufficiently explicit whether they can be successfully used in practical applications. The present work therefore focuses on the selection of best BR indicators in both instantaneous and overall cases. A modified ethanol fermentation model is used as a case study. The results indicate that the mathematical product of dynamic logarithmic gain and desired product concentration at a given time is the best instantaneous BR indicator, whereas its value at the end time of the fermentation process is the best overall BR indicator. The former is useful for observing the time course of the desired product concentration and determining a process time to be terminated. The latter is for ranking bottleneck enzymes to determine which enzyme activity should be changed to attain a higher desired product concentration. Moreover, discussion is made on the utilization of the overall BR indicators to predict how much the final desired product concentration is increased. DEWEY : 660 ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie100911h