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Development of electrochemical method for the determination of chlorzoxazone drug and its analytical applications to pharmaceutical dosage form and human biological fluids / Jyothi C. Abbar in Industrial & engineering chemistry research, Vol. 51 N° 1 (Janvier 2012) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 51 N° 1 (Janvier 2012) . - pp. 111-118 Titre : Development of electrochemical method for the determination of chlorzoxazone drug and its analytical applications to pharmaceutical dosage form and human biological fluids Type de document : texte imprimé Auteurs : Jyothi C. Abbar, Auteur ; Sharanappa T. Nandibewoor, Auteur Année de publication : 2012 Article en page(s) : pp. 111-118 Note générale : Chimie industrielle Langues : Anglais (eng) Mots-clés : Human  Electrochemical  method Résumé : The electrochemical behavior of chlorzoxazone drug at glassy carbon electrode has been investigated for the first time using cyclic and square wave voltammetric techniques. The dependence of the current on pH, concentration, and scan rate was investigated to optimize the experimental conditions for determination ofchlorzoxazone. The anodic peak was characterized and the process was diffusion-controlled. The number of electrons transferred in the oxidation process was calculated and a plausible oxidation mechanism was proposed. In the range of 8.0 x 10―7 to 1.0 x 10―5 M, the current measured by square wave voltammetry presents a good linear property as a function of the concentration of chlorzoxazone with a detection limit of 4.41 x 10―8 M with good selectivity and sensitivity. The proposed method was successfully applied to chlorzoxazone determination under physiological condition in pharmaceutical samples and for the detection of chlorzoxazone in human biological fluids. This method can be employed in clinical analysis, quality control, and routine determination of drugs in pharmaceutical formulations. DEWEY : 660 ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=25476452 [article] Development of electrochemical method for the determination of chlorzoxazone drug and its analytical applications to pharmaceutical dosage form and human biological fluids [texte imprimé] / Jyothi C. Abbar, Auteur ; Sharanappa T. Nandibewoor, Auteur . - 2012 . - pp. 111-118. Chimie industrielle Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 51 N° 1 (Janvier 2012) . - pp. 111-118 Mots-clés : Human  Electrochemical  method Résumé : The electrochemical behavior of chlorzoxazone drug at glassy carbon electrode has been investigated for the first time using cyclic and square wave voltammetric techniques. The dependence of the current on pH, concentration, and scan rate was investigated to optimize the experimental conditions for determination ofchlorzoxazone. The anodic peak was characterized and the process was diffusion-controlled. The number of electrons transferred in the oxidation process was calculated and a plausible oxidation mechanism was proposed. In the range of 8.0 x 10―7 to 1.0 x 10―5 M, the current measured by square wave voltammetry presents a good linear property as a function of the concentration of chlorzoxazone with a detection limit of 4.41 x 10―8 M with good selectivity and sensitivity. The proposed method was successfully applied to chlorzoxazone determination under physiological condition in pharmaceutical samples and for the detection of chlorzoxazone in human biological fluids. This method can be employed in clinical analysis, quality control, and routine determination of drugs in pharmaceutical formulations. DEWEY : 660 ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=25476452

Mechanistic investigation of uncatalyzed and osmium(VIII) catalyzed oxidation of guanidine by Ag(III) periodate complex in aqueous alkaline medium / Jyothi C. Abbar in Industrial & engineering chemistry research, Vol. 48 N° 16 (Août 2009) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 48 N° 16 (Août 2009) . - pp. 7550–7560 Titre : Mechanistic investigation of uncatalyzed and osmium(VIII) catalyzed oxidation of guanidine by Ag(III) periodate complex in aqueous alkaline medium : a comparative kinetic approach Type de document : texte imprimé Auteurs : Jyothi C. Abbar, Auteur ; Shekappa D. Lamani, Auteur ; Sharanappa T. Nandibewoor, Auteur Année de publication : 2009 Article en page(s) : pp. 7550–7560 Note générale : Chemical engineering Langues : Anglais (eng) Mots-clés : Guanidine  hydrochlorid  Diperiodatoargentate(III)  Catalyzed  oxidation Résumé : The oxidation of guanidine hydrochloride (GH) by diperiodatoargentate(III) (DPA) has been investigated both in the absence and presence of [Os(VIII)] catalyst in alkaline medium at a constant ionic strength of 0.10 mol dm−3 spectrophotometrically. The oxidation products were identified by spectral studies. The stiochiometry was same in both the cases, i.e., [GH]/[DPA] = 1:1. In both the catalyzed and uncatalyzed cases, the order of the reaction with respect to [DPA] was unity while the order with respect to [GH] was <1 over the concentration range studied. The rate increased with an increase in [OH−] and decreased with an increase in [IO4−]. The order with respect to [Os(VIII)] was unity. Suitable mechanisms were proposed. The reaction constants involved in the different steps of the reaction mechanisms were calculated for both reactions. Kinetic experiments suggest that [Ag(H2IO6)(H2O)2] is the reactive silver(III) species and [OsO4(OH)2]2− is the reactive Os(VIII) species. En ligne : http://pubs.acs.org/doi/abs/10.1021/ie900691z [article] Mechanistic investigation of uncatalyzed and osmium(VIII) catalyzed oxidation of guanidine by Ag(III) periodate complex in aqueous alkaline medium : a comparative kinetic approach [texte imprimé] / Jyothi C. Abbar, Auteur ; Shekappa D. Lamani, Auteur ; Sharanappa T. Nandibewoor, Auteur . - 2009 . - pp. 7550–7560. Chemical engineering Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 48 N° 16 (Août 2009) . - pp. 7550–7560 Mots-clés : Guanidine  hydrochlorid  Diperiodatoargentate(III)  Catalyzed  oxidation Résumé : The oxidation of guanidine hydrochloride (GH) by diperiodatoargentate(III) (DPA) has been investigated both in the absence and presence of [Os(VIII)] catalyst in alkaline medium at a constant ionic strength of 0.10 mol dm−3 spectrophotometrically. The oxidation products were identified by spectral studies. The stiochiometry was same in both the cases, i.e., [GH]/[DPA] = 1:1. In both the catalyzed and uncatalyzed cases, the order of the reaction with respect to [DPA] was unity while the order with respect to [GH] was <1 over the concentration range studied. The rate increased with an increase in [OH−] and decreased with an increase in [IO4−]. The order with respect to [Os(VIII)] was unity. Suitable mechanisms were proposed. The reaction constants involved in the different steps of the reaction mechanisms were calculated for both reactions. Kinetic experiments suggest that [Ag(H2IO6)(H2O)2] is the reactive silver(III) species and [OsO4(OH)2]2− is the reactive Os(VIII) species. En ligne : http://pubs.acs.org/doi/abs/10.1021/ie900691z