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Equilibrium and kinetics of reactiveextraction of ibuprofen enantiomers from organic solution by hydroxypropyl - B - cyclodextrin / Kewen Tang in Industrial & engineering chemistry research, Vol. 51 N° 2 (Janvier 2012) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 51 N° 2 (Janvier 2012) . - pp. 964-971 Titre : Equilibrium and kinetics of reactiveextraction of ibuprofen enantiomers from organic solution by hydroxypropyl - B - cyclodextrin Type de document : texte imprimé Auteurs : Kewen Tang, Auteur ; Jian Cai, Auteur ; Panliang Zhang, Auteur Année de publication : 2012 Article en page(s) : pp. 964-971 Note générale : Chimie industrielle Langues : Anglais (eng) Mots-clés : Enantiomer  Kinetics Résumé : This paper reports on the equilibrium and kinetics of the reactive extraction of hydrophobic ibuprofen (IBU) enantiomers from the organic phase to the aqueous phase by hydroxypropyl-β-cyclodextrin (HP-β-CD). The modeling and experimental data of extraction performance factors were investigated to obtain the optimal extraction conditions. The best conditions identified involve the use of an HP-β-CD concentration of 0.03 mol/L and pH value of 2.5 at 10 °C. The theory of extraction accompanied by chemical reactions was used to obtain the intrinsic kinetics of the extraction of IBU enantiomers by HP- β-CD. The effects of process parameters, including the agitation speed, interfacial area, initial concentration of IBU enantiomers, initial concentration of extractant, and pH value of aqueous phase, on the initial extraction rate were separately studied. The reactions are first order in IBU and second order in HP-β-CD with forward rate constants of 7.21 x 10―4 m6/(mol2·s) for S-LBU and 4.58 × 10―4 m6/(mol2·s) for R-IBU, respectively. DEWEY : 660 ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=25476429 [article] Equilibrium and kinetics of reactiveextraction of ibuprofen enantiomers from organic solution by hydroxypropyl - B - cyclodextrin [texte imprimé] / Kewen Tang, Auteur ; Jian Cai, Auteur ; Panliang Zhang, Auteur . - 2012 . - pp. 964-971. Chimie industrielle Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 51 N° 2 (Janvier 2012) . - pp. 964-971 Mots-clés : Enantiomer  Kinetics Résumé : This paper reports on the equilibrium and kinetics of the reactive extraction of hydrophobic ibuprofen (IBU) enantiomers from the organic phase to the aqueous phase by hydroxypropyl-β-cyclodextrin (HP-β-CD). The modeling and experimental data of extraction performance factors were investigated to obtain the optimal extraction conditions. The best conditions identified involve the use of an HP-β-CD concentration of 0.03 mol/L and pH value of 2.5 at 10 °C. The theory of extraction accompanied by chemical reactions was used to obtain the intrinsic kinetics of the extraction of IBU enantiomers by HP- β-CD. The effects of process parameters, including the agitation speed, interfacial area, initial concentration of IBU enantiomers, initial concentration of extractant, and pH value of aqueous phase, on the initial extraction rate were separately studied. The reactions are first order in IBU and second order in HP-β-CD with forward rate constants of 7.21 x 10―4 m6/(mol2·s) for S-LBU and 4.58 × 10―4 m6/(mol2·s) for R-IBU, respectively. DEWEY : 660 ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=25476429

Experimental and model study on enantioselective extraction of phenylglycine enantiomers with BINAP–metal complexes / Kewen Tang in Industrial & engineering chemistry research, Vol. 51 N° 46 (Novembre 2012) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 51 N° 46 (Novembre 2012) . - pp. 15233-15241 Titre : Experimental and model study on enantioselective extraction of phenylglycine enantiomers with BINAP–metal complexes Type de document : texte imprimé Auteurs : Kewen Tang, Auteur ; Guohui Wu, Auteur ; Panliang Zhang, Auteur Année de publication : 2013 Article en page(s) : pp. 15233-15241 Note générale : Industrial chemistry Langues : Anglais (eng) Mots-clés : Enantiomer  Modeling Résumé : Enantioselective extraction of phenylglycine (PHG) enantiomers with (S)-BINAP―metal complexes as chiral selector was investigated. A reactive extraction model was established to interpret the experimental data. The complexation equilibrium constants and other important parameters required by the model were determined experimentally. The extraction system shows good selectivity toward PHG enantiomers. The complex [(S)-BINAP(CH3CN)Cu][PF6] (BINAP-Cu) exhibits the highest selectivity among the selectors studied, which is dissolved in the organic phase and preferentially extracts L-PHG from aqueous phase. Efficiency of extraction depends, often strongly, on a number of process variables, including types of organic solvents and metal precursors, concentration of selector, pH, and temperature. The model quantitatively predicts extraction performance as a function of key operating parameters, providing a simple computational approach to process optimization. The model was verified experimentally with excellent results. ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=26679643 [article] Experimental and model study on enantioselective extraction of phenylglycine enantiomers with BINAP–metal complexes [texte imprimé] / Kewen Tang, Auteur ; Guohui Wu, Auteur ; Panliang Zhang, Auteur . - 2013 . - pp. 15233-15241. Industrial chemistry Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 51 N° 46 (Novembre 2012) . - pp. 15233-15241 Mots-clés : Enantiomer  Modeling Résumé : Enantioselective extraction of phenylglycine (PHG) enantiomers with (S)-BINAP―metal complexes as chiral selector was investigated. A reactive extraction model was established to interpret the experimental data. The complexation equilibrium constants and other important parameters required by the model were determined experimentally. The extraction system shows good selectivity toward PHG enantiomers. The complex [(S)-BINAP(CH3CN)Cu][PF6] (BINAP-Cu) exhibits the highest selectivity among the selectors studied, which is dissolved in the organic phase and preferentially extracts L-PHG from aqueous phase. Efficiency of extraction depends, often strongly, on a number of process variables, including types of organic solvents and metal precursors, concentration of selector, pH, and temperature. The model quantitatively predicts extraction performance as a function of key operating parameters, providing a simple computational approach to process optimization. The model was verified experimentally with excellent results. ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=26679643