Equilibrium and kinetics of reactiveextraction of ibuprofen enantiomers from organic solution by hydroxypropyl - B - cyclodextrin / Kewen Tang in Industrial & engineering chemistry research, Vol. 51 N° 2 (Janvier 2012)  

Public ISBD [article]  inIndustrial & engineering chemistry research > Vol. 51 N° 2 (Janvier 2012) . - pp. 964-971 Titre : Equilibrium and kinetics of reactiveextraction of ibuprofen enantiomers from organic solution by hydroxypropyl - B - cyclodextrin Type de document : texte imprimé Auteurs : Kewen Tang, Auteur ; Jian Cai, Auteur ; Panliang Zhang, Auteur Année de publication : 2012 Article en page(s) : pp. 964-971 Note générale : Chimie industrielle Langues : Anglais (eng) Mots-clés : Enantiomer Kinetics Résumé : This paper reports on the equilibrium and kinetics of the reactive extraction of hydrophobic ibuprofen (IBU) enantiomers from the organic phase to the aqueous phase by hydroxypropyl-β-cyclodextrin (HP-β-CD). The modeling and experimental data of extraction performance factors were investigated to obtain the optimal extraction conditions. The best conditions identified involve the use of an HP-β-CD concentration of 0.03 mol/L and pH value of 2.5 at 10 °C. The theory of extraction accompanied by chemical reactions was used to obtain the intrinsic kinetics of the extraction of IBU enantiomers by HP- β-CD. The effects of process parameters, including the agitation speed, interfacial area, initial concentration of IBU enantiomers, initial concentration of extractant, and pH value of aqueous phase, on the initial extraction rate were separately studied. The reactions are first order in IBU and second order in HP-β-CD with forward rate constants of 7.21 x 10―4 m6/(mol2·s) for S-LBU and 4.58 × 10―4 m6/(mol2·s) for R-IBU, respectively. DEWEY : 660 ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=25476429 [article] Equilibrium and kinetics of reactiveextraction of ibuprofen enantiomers from organic solution by hydroxypropyl - B - cyclodextrin [texte imprimé] / Kewen Tang, Auteur ; Jian Cai, Auteur ; Panliang Zhang, Auteur . - 2012 . - pp. 964-971. Chimie industrielle Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 51 N° 2 (Janvier 2012) . - pp. 964-971 Mots-clés : Enantiomer Kinetics Résumé : This paper reports on the equilibrium and kinetics of the reactive extraction of hydrophobic ibuprofen (IBU) enantiomers from the organic phase to the aqueous phase by hydroxypropyl-β-cyclodextrin (HP-β-CD). The modeling and experimental data of extraction performance factors were investigated to obtain the optimal extraction conditions. The best conditions identified involve the use of an HP-β-CD concentration of 0.03 mol/L and pH value of 2.5 at 10 °C. The theory of extraction accompanied by chemical reactions was used to obtain the intrinsic kinetics of the extraction of IBU enantiomers by HP- β-CD. The effects of process parameters, including the agitation speed, interfacial area, initial concentration of IBU enantiomers, initial concentration of extractant, and pH value of aqueous phase, on the initial extraction rate were separately studied. The reactions are first order in IBU and second order in HP-β-CD with forward rate constants of 7.21 x 10―4 m6/(mol2·s) for S-LBU and 4.58 × 10―4 m6/(mol2·s) for R-IBU, respectively. DEWEY : 660 ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=25476429

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