| Titre : | Separation and purification of schisandrin B from fructus schisandrae (2008) |
| Auteurs : | Ka F. Luk, Auteur ; Kam M. Ko, Auteur ; Ka M. Ng, Auteur |
| Type de document : | Article : texte imprimé |
| Dans : | Industrial & engineering chemistry research (Vol. 47 n°12, Juin 2008) |
| Article en page(s) : | p. 4193–4201 |
| Note générale : | Bibliogr. p. 4201 |
| Langues : | Anglais |
| Tags : | Schisandrin B ; Fructus Schisandrae ; Solid–liquid extraction ; Adsorption-desorption |
| Résumé : | Schisandrin B (Sch B) is the most abundant and biologically active dibenzocyclooctadiene lignan present in Fructus Schisandrae (FS). It is a highly desirable ingredient for a dietary supplement. While Sch B has been isolated from FS in the laboratory, the experimental procedure was usually lengthy and the yield was relatively low. The objective of this study is to develop a process that is amenable to large-scale recovery of Sch B from FS. The process starts with solid–liquid extraction of FS by petroleum ether to yield a Sch B-containing extract, which is then purified by removing the relatively nonpolar substances, mostly fatty oils, by an adsorption–desorption step. This is followed by a chromatographic process to isolate the Sch B-enriched fraction that is then used to yield Sch B by crystallization. |
| En ligne : | http://pubs.acs.org/doi/abs/10.1021/ie071317b |
