| Titre : | Kinetic modeling of immobilized lipase catalysis in synthesis of n-butyl levulinate (2008) |
| Auteurs : | Ganapati D. Yadav, Auteur |
| Type de document : | Article : texte imprimé |
| Dans : | Industrial & engineering chemistry research (Vol. 47 N°10, Mai 2008) |
| Article en page(s) : | p. 3358–3363 |
| Note générale : | Bibliogr. p. 3363 |
| Langues : | Anglais |
| Tags : | n-Butyl levulinate -- esterification ; Immobilized lipases |
| Résumé : | n-Butyl levulinate is used as an important intermediate having diverse applications. The present work focuses on the synthesis of n-butyl levulinate by esterification of levulinic acid with n-butanol by using immobilized lipases. Novozym 435 (Candida antarctica lipase) was found to be the most efficient catalyst, and tetra-butyl methyl ether was the best solvent. Effects of various parameters were studied to analyze the kinetics and mechanism of the lipase action. Ping-pong bi−bi mechanism with n-butanol substrate inhibition was found to describe the kinetics of the reaction. The kinetic parameters evaluated from initial rate data were used to simulate the experimental results. There was a very good agreement between theory and experiment. |
| En ligne : | http://pubs.acs.org/doi/abs/10.1021/ie800193f |
