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Kinetics and mechanistic investigation of decarboxylation for the oxidation of levofloxacin by chloroamine - T in acidic medium / Aftab Aslam Parwaz Khan in Industrial & engineering chemistry research, Vol. 51 N° 13 (Avril 2012) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 51 N° 13 (Avril 2012) . - pp. 4819–4824 Titre : Kinetics and mechanistic investigation of decarboxylation for the oxidation of levofloxacin by chloroamine - T in acidic medium Type de document : texte imprimé Auteurs : Aftab Aslam Parwaz Khan, Auteur ; Abdullah M. Asiri, Auteur ; Naved Azum, Auteur Année de publication : 2012 Article en page(s) : pp. 4819–4824 Note générale : Chimie industrielle Langues : Anglais (eng) Mots-clés : Kinetics  Decarboxylation Résumé : The mechanistic investigation of oxidation of levofloxacin (LF) has been studied by chloramine-T(CAT) in aqueous perchloric acid medium at 25 °C. The reaction followed first-order kinetics with respect to [CAT], [LF], and [H+] in their lower concentrations range, tending to zero-order at their higher concentrations. First-order kinetics with respect to [CAT] was observed for the oxidation of levofloxacin. An increase in perchloric acid concentration increased the rate of reaction. The effect of added products, ionic strength, and dielectric constant of the medium was studied on the rate of reaction. The main products were identified by spot test, FT-IR, and NMR. A mechanism was proposed on the basis of experimental results. The activation parameters with respect to the slow step of the mechanism was evaluated, and the thermodynamic parameters were also determined and discussed. ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie202483c [article] Kinetics and mechanistic investigation of decarboxylation for the oxidation of levofloxacin by chloroamine - T in acidic medium [texte imprimé] / Aftab Aslam Parwaz Khan, Auteur ; Abdullah M. Asiri, Auteur ; Naved Azum, Auteur . - 2012 . - pp. 4819–4824. Chimie industrielle Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 51 N° 13 (Avril 2012) . - pp. 4819–4824 Mots-clés : Kinetics  Decarboxylation Résumé : The mechanistic investigation of oxidation of levofloxacin (LF) has been studied by chloramine-T(CAT) in aqueous perchloric acid medium at 25 °C. The reaction followed first-order kinetics with respect to [CAT], [LF], and [H+] in their lower concentrations range, tending to zero-order at their higher concentrations. First-order kinetics with respect to [CAT] was observed for the oxidation of levofloxacin. An increase in perchloric acid concentration increased the rate of reaction. The effect of added products, ionic strength, and dielectric constant of the medium was studied on the rate of reaction. The main products were identified by spot test, FT-IR, and NMR. A mechanism was proposed on the basis of experimental results. The activation parameters with respect to the slow step of the mechanism was evaluated, and the thermodynamic parameters were also determined and discussed. ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie202483c