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Combined application of in Situ FBRM, ATR-FTIR, and raman on polymorphism transformation monitoring during the cooling crystallization / Yingying Zhao in Industrial & engineering chemistry research, Vol. 51 N° 38 (Septembre 2012) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 51 N° 38 (Septembre 2012) . - pp. 12530-12536 Titre : Combined application of in Situ FBRM, ATR-FTIR, and raman on polymorphism transformation monitoring during the cooling crystallization Type de document : texte imprimé Auteurs : Yingying Zhao, Auteur ; Junsheng Yuan, Auteur ; Zhiyong Ji, Auteur Année de publication : 2012 Article en page(s) : pp. 12530-12536 Note générale : Industrial chemistry Langues : Anglais (eng) Mots-clés : Crystallization  Cooling  Surveillance  Polymorphism  In  situ Résumé : This study evaluates the potential use of the FBRM, ATR-FTIR, and Raman for on line detection of polymorphic transformation of carbamazepine (CBZ) during the cooling crystallization. Changes in solution concentration as a function of time were quantified from the ATR-FTIR data. A new quantitative method of polymorphs ratio was developed using Raman spectroscopy for in situ monitoring during a solution-mediated transformation of carbamazepine from form II to form III in 1-propanol. The polymorphic forms initially crystallized from solution, in the absence of seeds, could be clearly identified by FBRM and showed good agreement with results of microscopic images. Furthermore, the kinetics of the conversion of carbamazepine from metastable form to the stable form at different cooling rates could be readily followed. ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=26399705 [article] Combined application of in Situ FBRM, ATR-FTIR, and raman on polymorphism transformation monitoring during the cooling crystallization [texte imprimé] / Yingying Zhao, Auteur ; Junsheng Yuan, Auteur ; Zhiyong Ji, Auteur . - 2012 . - pp. 12530-12536. Industrial chemistry Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 51 N° 38 (Septembre 2012) . - pp. 12530-12536 Mots-clés : Crystallization  Cooling  Surveillance  Polymorphism  In  situ Résumé : This study evaluates the potential use of the FBRM, ATR-FTIR, and Raman for on line detection of polymorphic transformation of carbamazepine (CBZ) during the cooling crystallization. Changes in solution concentration as a function of time were quantified from the ATR-FTIR data. A new quantitative method of polymorphs ratio was developed using Raman spectroscopy for in situ monitoring during a solution-mediated transformation of carbamazepine from form II to form III in 1-propanol. The polymorphic forms initially crystallized from solution, in the absence of seeds, could be clearly identified by FBRM and showed good agreement with results of microscopic images. Furthermore, the kinetics of the conversion of carbamazepine from metastable form to the stable form at different cooling rates could be readily followed. ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=26399705

Kinetics study on the liquid entrapment and melt transport of static and falling - film melt crystallization / Xiaobin Jiang in Industrial & engineering chemistry research, Vol. 51 N° 13 (Avril 2012) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 51 N° 13 (Avril 2012) . - pp. 5037-5044 Titre : Kinetics study on the liquid entrapment and melt transport of static and falling - film melt crystallization Type de document : texte imprimé Auteurs : Xiaobin Jiang, Auteur ; Baohong Hou, Auteur ; Yingying Zhao, Auteur Année de publication : 2012 Article en page(s) : pp. 5037-5044 Note générale : Chimie industrielle Langues : Anglais (eng) Mots-clés : Melt  crystallization  Falling  film  Transport  process  Kinetics Résumé : Experiments were carried out to study the kinetics of crystal growth and the sweating process in two kinds of melt crystallization modes: static melt crystallization (SMC) and falling-film melt crystallization (FFMC). The system utilized in this paper was hyperpure phosphoric acid with water and trace amounts of metal ions as impurities. The kinetic experimental data of crystal growth, liquid entrapment, and the melt-transport process were well fitted by power function equations (R2 > 0.947). The fractal and porous media theories were introduced to improve the model of melt transport and explain the difference between the two modes. The separation efficiencies of SMC and FFMC on different ion impurities were compared. The SMC mode separated calcium and ferrum ions with higher efficiency than the FFMC mode, while the FFMC mode separated sodium and magnesium ions better than the SMC mode. A combined operation mode was suggested to prepare hyperpure phosphoric acid in industrial applications. ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=25777943 [article] Kinetics study on the liquid entrapment and melt transport of static and falling - film melt crystallization [texte imprimé] / Xiaobin Jiang, Auteur ; Baohong Hou, Auteur ; Yingying Zhao, Auteur . - 2012 . - pp. 5037-5044. Chimie industrielle Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 51 N° 13 (Avril 2012) . - pp. 5037-5044 Mots-clés : Melt  crystallization  Falling  film  Transport  process  Kinetics Résumé : Experiments were carried out to study the kinetics of crystal growth and the sweating process in two kinds of melt crystallization modes: static melt crystallization (SMC) and falling-film melt crystallization (FFMC). The system utilized in this paper was hyperpure phosphoric acid with water and trace amounts of metal ions as impurities. The kinetic experimental data of crystal growth, liquid entrapment, and the melt-transport process were well fitted by power function equations (R2 > 0.947). The fractal and porous media theories were introduced to improve the model of melt transport and explain the difference between the two modes. The separation efficiencies of SMC and FFMC on different ion impurities were compared. The SMC mode separated calcium and ferrum ions with higher efficiency than the FFMC mode, while the FFMC mode separated sodium and magnesium ions better than the SMC mode. A combined operation mode was suggested to prepare hyperpure phosphoric acid in industrial applications. ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=25777943