Solubility and micronization of griseofulvin in subcritical water / Adam G. Carr in Industrial & engineering chemistry research, Vol. 49 N° 7 (Avril 2010)  

Public ISBD [article]  inIndustrial & engineering chemistry research > Vol. 49 N° 7 (Avril 2010) . - pp. 3403–3410 Titre : Solubility and micronization of griseofulvin in subcritical water Type de document : texte imprimé Auteurs : Adam G. Carr, Auteur ; Raffaella Mammucari, Auteur ; Neil R. Foster, Auteur Année de publication : 2010 Article en page(s) : pp. 3403–3410 Note générale : Industrial Chemstry Langues : Anglais (eng) Mots-clés : Solubility Micronization Griseofulvin Subcritical Water Résumé : The technology developed in this work takes advantage of the temperature-sensitive dielectric constant of water to micronize hydrophobic compounds. At elevated temperatures subcritical water (SBCW) is a good solvent for nonpolar compounds, while at ordinary temperatures it behaves as an antisolvent. The solubility of the model compound griseofulvin in SBCW was determined at 70 bar and temperatures between 130 and 170 °C. In this work griseofulvin was dissolved in subcritical water. The resulting subcritical solution was then injected into water at room temperature to rapidly quench the temperature and trigger precipitation of the solute. The resulting particle morphology was markedly dependent on operating conditions such as temperature and concentration of the subcritical solution. It was possible to generate microparticles of griseofulvin with controllable morphologies. The process is rapid and does not involve the use of organic solvents. ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie901189r [article] Solubility and micronization of griseofulvin in subcritical water [texte imprimé] / Adam G. Carr, Auteur ; Raffaella Mammucari, Auteur ; Neil R. Foster, Auteur . - 2010 . - pp. 3403–3410. Industrial Chemstry Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 49 N° 7 (Avril 2010) . - pp. 3403–3410 Mots-clés : Solubility Micronization Griseofulvin Subcritical Water Résumé : The technology developed in this work takes advantage of the temperature-sensitive dielectric constant of water to micronize hydrophobic compounds. At elevated temperatures subcritical water (SBCW) is a good solvent for nonpolar compounds, while at ordinary temperatures it behaves as an antisolvent. The solubility of the model compound griseofulvin in SBCW was determined at 70 bar and temperatures between 130 and 170 °C. In this work griseofulvin was dissolved in subcritical water. The resulting subcritical solution was then injected into water at room temperature to rapidly quench the temperature and trigger precipitation of the solute. The resulting particle morphology was markedly dependent on operating conditions such as temperature and concentration of the subcritical solution. It was possible to generate microparticles of griseofulvin with controllable morphologies. The process is rapid and does not involve the use of organic solvents. ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie901189r

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Solubility, solubility modeling, and precipitation of naproxen from subcritical water solutions / Adam G. Carr in Industrial & engineering chemistry research, Vol. 49 N° 19 (Octobre 2010)  

Public ISBD [article]  inIndustrial & engineering chemistry research > Vol. 49 N° 19 (Octobre 2010) . - pp. 9385–9393 Titre : Solubility, solubility modeling, and precipitation of naproxen from subcritical water solutions Type de document : texte imprimé Auteurs : Adam G. Carr, Auteur ; Raffaella Mammucari, Auteur ; Neil R. Foster, Auteur Année de publication : 2010 Article en page(s) : pp. 9385–9393 Note générale : Chimie industrielle Langues : Anglais (eng) Mots-clés : Solubility naproxen Résumé : In this paper, the solubility of naproxen in subcritical water (SBCW) between 130 and 170 °C is measured. The solubility of naproxen in SBCW was correlated to temperature using a Modified Universal Functional Activity Coefficient (M-UNIFAC) model. Errors in the model were minimized by optimizing the water−carboxylic acid interaction parameter, as other side groups were already optimized. The micronization of naproxen via processes that used the tunable solvent power of SBCW was conducted. Two precipitation techniques were developed. In the first technique, the temperature of a SBCW solution containing naproxen was rapidly quenched by injection into cold water solutions. The quenching media were either pure water or 1% w/v solution of lactose in water. Variations in SBCW−naproxen solution injection temperature and supersaturation ratios in pure water were examined. Product morphology was robust toward changes in operating conditions and consisted of flaky crystals with a particle size distribution ranging from 0.5 to 100 μm. Under specific experimental conditions, naproxen crystals formed spherical agglomerates. Particles produced from lactose/water solutions were slightly smaller than those produced from pure water. In the second technique, precipitation was induced by vaporization of SBCW−naproxen solutions. The SBCW solutions were injected into a vessel that was connected to a vacuum pump. The process generated large naproxen microcrystals with broad particle size distributions. ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie9019825 [article] Solubility, solubility modeling, and precipitation of naproxen from subcritical water solutions [texte imprimé] / Adam G. Carr, Auteur ; Raffaella Mammucari, Auteur ; Neil R. Foster, Auteur . - 2010 . - pp. 9385–9393. Chimie industrielle Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 49 N° 19 (Octobre 2010) . - pp. 9385–9393 Mots-clés : Solubility naproxen Résumé : In this paper, the solubility of naproxen in subcritical water (SBCW) between 130 and 170 °C is measured. The solubility of naproxen in SBCW was correlated to temperature using a Modified Universal Functional Activity Coefficient (M-UNIFAC) model. Errors in the model were minimized by optimizing the water−carboxylic acid interaction parameter, as other side groups were already optimized. The micronization of naproxen via processes that used the tunable solvent power of SBCW was conducted. Two precipitation techniques were developed. In the first technique, the temperature of a SBCW solution containing naproxen was rapidly quenched by injection into cold water solutions. The quenching media were either pure water or 1% w/v solution of lactose in water. Variations in SBCW−naproxen solution injection temperature and supersaturation ratios in pure water were examined. Product morphology was robust toward changes in operating conditions and consisted of flaky crystals with a particle size distribution ranging from 0.5 to 100 μm. Under specific experimental conditions, naproxen crystals formed spherical agglomerates. Particles produced from lactose/water solutions were slightly smaller than those produced from pure water. In the second technique, precipitation was induced by vaporization of SBCW−naproxen solutions. The SBCW solutions were injected into a vessel that was connected to a vacuum pump. The process generated large naproxen microcrystals with broad particle size distributions. ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie9019825

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