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Engineering pharmaceutical fine particles of budesonide for dry powder inhalation (DPI) / Ting-Ting Hu in Industrial & engineering chemistry research, Vol. 47 N° 23 (Décembre 2008) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 47 N° 23 (Décembre 2008) . - p. 9623–9627 Titre : Engineering pharmaceutical fine particles of budesonide for dry powder inhalation (DPI) Type de document : texte imprimé Auteurs : Ting-Ting Hu, Auteur ; Hong Zhao, Auteur ; Li-Chuan Jiang, Auteur Année de publication : 2009 Article en page(s) : p. 9623–9627 Note générale : Chemistry engineering Langues : Anglais (eng) Mots-clés : Engineering  pharmaceutical  Fine  particles  Dry  powder Résumé : Budesonide, as one of the inhaled glucocorticosteroids, is widely used in the treatment of asthma by pulmonary delivery. The purpose of this study was to prepare ultra-fine budesonide particles by antisolvent precipitation for dry powder inhalation. Both methanol and acetone were used to make the budesonide solution, and water was chosen as the antisolvent to induce precipitation. Hydroxypropyl cellulose and tyloxapol were added as the stabilizers. The results revealed that crystals of rectangular shape could be obtained from an acetone−water system while elliptic particles were obtained from a methanol−water system. They both had a flaky morphology, no more than 5 µm in length and 300 nm in thickness, and were formed into agglomerates. When the stabilizers were present, uniform spindle or ellipsoidal particles less than 5 µm in diameter could be prepared. All the prepared particles had the same crystalline structure as the commercial budesonide product, as assessed by X-ray diffraction. In vitro evaluation with an Aerolizer inhaler and a multistage liquid impinger (MSLI) showed that the flaky particles had better aerosol performance, because they both achieved a FPFemitted value of over 69%. However, the spindle or ellipsoidal particles had poor dispersibility, because of FPFemitted values of 23 ± 2% and 26 ± 3%, respectively. En ligne : http://pubs.acs.org/doi/abs/10.1021/ie0715052 [article] Engineering pharmaceutical fine particles of budesonide for dry powder inhalation (DPI) [texte imprimé] / Ting-Ting Hu, Auteur ; Hong Zhao, Auteur ; Li-Chuan Jiang, Auteur . - 2009 . - p. 9623–9627. Chemistry engineering Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 47 N° 23 (Décembre 2008) . - p. 9623–9627 Mots-clés : Engineering  pharmaceutical  Fine  particles  Dry  powder Résumé : Budesonide, as one of the inhaled glucocorticosteroids, is widely used in the treatment of asthma by pulmonary delivery. The purpose of this study was to prepare ultra-fine budesonide particles by antisolvent precipitation for dry powder inhalation. Both methanol and acetone were used to make the budesonide solution, and water was chosen as the antisolvent to induce precipitation. Hydroxypropyl cellulose and tyloxapol were added as the stabilizers. The results revealed that crystals of rectangular shape could be obtained from an acetone−water system while elliptic particles were obtained from a methanol−water system. They both had a flaky morphology, no more than 5 µm in length and 300 nm in thickness, and were formed into agglomerates. When the stabilizers were present, uniform spindle or ellipsoidal particles less than 5 µm in diameter could be prepared. All the prepared particles had the same crystalline structure as the commercial budesonide product, as assessed by X-ray diffraction. In vitro evaluation with an Aerolizer inhaler and a multistage liquid impinger (MSLI) showed that the flaky particles had better aerosol performance, because they both achieved a FPFemitted value of over 69%. However, the spindle or ellipsoidal particles had poor dispersibility, because of FPFemitted values of 23 ± 2% and 26 ± 3%, respectively. En ligne : http://pubs.acs.org/doi/abs/10.1021/ie0715052

Highly transparent and multifunctional polymer nanohybrid film with superhigh ZnO content synthesized by a bulk polymerization method / Hai-Tao Liu in Industrial & engineering chemistry research, Vol. 51 N° 19 (Mai 2012) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 51 N° 19 (Mai 2012) . - pp. 6753-6759 Titre : Highly transparent and multifunctional polymer nanohybrid film with superhigh ZnO content synthesized by a bulk polymerization method Type de document : texte imprimé Auteurs : Hai-Tao Liu, Auteur ; Xiao-Fei Zeng, Auteur ; Hong Zhao, Auteur Année de publication : 2012 Article en page(s) : pp. 6753-6759 Note générale : Industrial chemistry Langues : Anglais (eng) Mots-clés : Polymerization Résumé : Highly transparent and multifunctional ZnO/poly(n-butyl methacrylate) (ZnO/PBMA) nanohybrid films with superhigh contents of ZnO nanoparticles (NPs) were synthesized by a bulk polymerization method. The structure; morphology; and optical, mechanical, and thermal properties of the obtained nanohybrid films were studied. ZnO NPs were dispersed uniformly and retained their original size (4―6 nm) in the PBMA matrix without any aggregation. The ZnO/PBMA nanohybrid films allowed more than 90% of visible light at 550 nm to pass and maintained almost the same high transparency as pure PBMA film even when the ZnO NP content was as high as 60 wt %. The nanohybrid films embedded with ZnO NPs exhibited significantly enhanced multifunctional performance, including excellent UV-shielding properties, good thermal stability, high surface hardness, and desired flexibility. In particular, the coefficient of thermal expansion (CTE) of the nanohybrid films dearly decreased to 193 from 325 ppm/K for pure PBMA below the glass transition temperature (Tg) and strikingly decreased from 5378 to 1373 ppm/K after the glass transition. The ZnO/polymer nanohybrids synthesized in this work are promising for the fabrication of optical devices with high transparency, such as flexible displays, optical filters, and flexible solar cells. ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=25900230 [article] Highly transparent and multifunctional polymer nanohybrid film with superhigh ZnO content synthesized by a bulk polymerization method [texte imprimé] / Hai-Tao Liu, Auteur ; Xiao-Fei Zeng, Auteur ; Hong Zhao, Auteur . - 2012 . - pp. 6753-6759. Industrial chemistry Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 51 N° 19 (Mai 2012) . - pp. 6753-6759 Mots-clés : Polymerization Résumé : Highly transparent and multifunctional ZnO/poly(n-butyl methacrylate) (ZnO/PBMA) nanohybrid films with superhigh contents of ZnO nanoparticles (NPs) were synthesized by a bulk polymerization method. The structure; morphology; and optical, mechanical, and thermal properties of the obtained nanohybrid films were studied. ZnO NPs were dispersed uniformly and retained their original size (4―6 nm) in the PBMA matrix without any aggregation. The ZnO/PBMA nanohybrid films allowed more than 90% of visible light at 550 nm to pass and maintained almost the same high transparency as pure PBMA film even when the ZnO NP content was as high as 60 wt %. The nanohybrid films embedded with ZnO NPs exhibited significantly enhanced multifunctional performance, including excellent UV-shielding properties, good thermal stability, high surface hardness, and desired flexibility. In particular, the coefficient of thermal expansion (CTE) of the nanohybrid films dearly decreased to 193 from 325 ppm/K for pure PBMA below the glass transition temperature (Tg) and strikingly decreased from 5378 to 1373 ppm/K after the glass transition. The ZnO/polymer nanohybrids synthesized in this work are promising for the fabrication of optical devices with high transparency, such as flexible displays, optical filters, and flexible solar cells. ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=25900230