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Correlation of solubilities of hydrophilic pharmaceuticals versus dielectric constants of binary solvents / Xinwei Zhang in Industrial & engineering chemistry research, Vol. 51 N° 19 (Mai 2012) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 51 N° 19 (Mai 2012) . - pp. 6933-693 Titre : Correlation of solubilities of hydrophilic pharmaceuticals versus dielectric constants of binary solvents Type de document : texte imprimé Auteurs : Xinwei Zhang, Auteur ; Qiuxiang Yin, Auteur ; Penglei Cui, Auteur Année de publication : 2012 Article en page(s) : pp. 6933-693 Note générale : Industrial chemistry Langues : Anglais (eng) Mots-clés : Solubility  Correlation  analysis  Correlation Résumé : In this paper, the polarity of binary solvents was studied by the sum law of cube roots of the dielectric constant During the antisolvent crystallization process, the composition of the binary solvents and their dielectric constants changed simultaneously. These results demonstrated that variation of the solubility is dependent on the polarity of the binary solvents. On the basis of experiments, a new model was put forward to quantitatively describe the relationship between the solubility of hydrophilic pharmaceuticals and the dielectric constants of the binary solvents. Furthermore, this model was tested and verified by solubility data of other pharmaceuticals published in the literature with high accuracy. ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=25900247 [article] Correlation of solubilities of hydrophilic pharmaceuticals versus dielectric constants of binary solvents [texte imprimé] / Xinwei Zhang, Auteur ; Qiuxiang Yin, Auteur ; Penglei Cui, Auteur . - 2012 . - pp. 6933-693. Industrial chemistry Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 51 N° 19 (Mai 2012) . - pp. 6933-693 Mots-clés : Solubility  Correlation  analysis  Correlation Résumé : In this paper, the polarity of binary solvents was studied by the sum law of cube roots of the dielectric constant During the antisolvent crystallization process, the composition of the binary solvents and their dielectric constants changed simultaneously. These results demonstrated that variation of the solubility is dependent on the polarity of the binary solvents. On the basis of experiments, a new model was put forward to quantitatively describe the relationship between the solubility of hydrophilic pharmaceuticals and the dielectric constants of the binary solvents. Furthermore, this model was tested and verified by solubility data of other pharmaceuticals published in the literature with high accuracy. ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=25900247

Evidence of hydrogen-bond formation during crystallization of cefodizime sodium from induction-time measurements and in situ raman spectroscopy / Penglei Cui in Industrial & engineering chemistry research, Vol. 51 N° 42 (Octobre 2012) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 51 N° 42 (Octobre 2012) . - pp. 13663-13669 Titre : Evidence of hydrogen-bond formation during crystallization of cefodizime sodium from induction-time measurements and in situ raman spectroscopy Type de document : texte imprimé Auteurs : Penglei Cui, Auteur ; Xinwei Zhang, Auteur ; Qiuxiang Yin, Auteur Année de publication : 2012 Article en page(s) : pp. 13663-13669 Note générale : Industrial chemistry Langues : Anglais (eng) Mots-clés : In  situ  Induction  Crystallization Résumé : In this article, the nudeation process of cefodizime sodium was analyzed from two perspectives: induction time and hydrogen-bond formation. According to classical nucleation theory, the correlation of the induction time indicated that heterogeneous nucleation dominates the nucleation process at lower supersaturation whereas homogeneous nucleation is the main mechanism at higher supersaturation. Then, in situ Raman spectroscopy was used to investigate the probability of hydrogen-bond formation in the supersaturated solution and the nucleation process of cefodizime sodium. A central feature of the hydrogen bonding is that the probability reaches a maximum value at the nucleation point, which can be used to relate the probability of hydrogen-bond formation to the induction time. Furthermore, SEM imaging affords fundamental information to illustrate the effect of supersaturation on the morphology of cefodizime sodium crystals: agglomerated small needlelike particles preferentially formed at a high supersaturation, whereas large needlelike particles formed at low supersaturation. ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=26508191 [article] Evidence of hydrogen-bond formation during crystallization of cefodizime sodium from induction-time measurements and in situ raman spectroscopy [texte imprimé] / Penglei Cui, Auteur ; Xinwei Zhang, Auteur ; Qiuxiang Yin, Auteur . - 2012 . - pp. 13663-13669. Industrial chemistry Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 51 N° 42 (Octobre 2012) . - pp. 13663-13669 Mots-clés : In  situ  Induction  Crystallization Résumé : In this article, the nudeation process of cefodizime sodium was analyzed from two perspectives: induction time and hydrogen-bond formation. According to classical nucleation theory, the correlation of the induction time indicated that heterogeneous nucleation dominates the nucleation process at lower supersaturation whereas homogeneous nucleation is the main mechanism at higher supersaturation. Then, in situ Raman spectroscopy was used to investigate the probability of hydrogen-bond formation in the supersaturated solution and the nucleation process of cefodizime sodium. A central feature of the hydrogen bonding is that the probability reaches a maximum value at the nucleation point, which can be used to relate the probability of hydrogen-bond formation to the induction time. Furthermore, SEM imaging affords fundamental information to illustrate the effect of supersaturation on the morphology of cefodizime sodium crystals: agglomerated small needlelike particles preferentially formed at a high supersaturation, whereas large needlelike particles formed at low supersaturation. ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=26508191