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Product design / Yeuk Tin Lau in Industrial & engineering chemistry research, Vol. 51 N° 21 (Mai 2012) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 51 N° 21 (Mai 2012) . - pp. 7320-7326 Titre : Product design : A nanomized nutraceutical with enhanced bioactivity and bioavailability Type de document : texte imprimé Auteurs : Yeuk Tin Lau, Auteur ; Na Chen, Auteur ; Kam Ming Ko, Auteur Année de publication : 2012 Article en page(s) : pp. 7320-7326 Note générale : Industrial chemistry Langues : Anglais (eng) Mots-clés : Bioavailability  Product  development Résumé : This study considered the design and process development of nanomized products in two product forms: nanoemulsion and nanodispersible solids. The effect of product formulation and processing conditions on product attributes such as particle size and appearance were studied using orange oil and Oil Red O as model compounds. The relationship between particle size and product quality in terms of bioactivity and bioavaflabflity was illustrated using schisandrin B, a strong antioxidant, as a model drug. The bioactivity as measured by in vivo glutathione regeneration capacity assay of schisandrin B with an average size of 45 nm was nearly double that of the original coarse schisandrin B; the corresponding bioavailability as measured by the plasma schisandrin B level in an animal study was 14.5-fold higher. ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=25948472 [article] Product design : A nanomized nutraceutical with enhanced bioactivity and bioavailability [texte imprimé] / Yeuk Tin Lau, Auteur ; Na Chen, Auteur ; Kam Ming Ko, Auteur . - 2012 . - pp. 7320-7326. Industrial chemistry Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 51 N° 21 (Mai 2012) . - pp. 7320-7326 Mots-clés : Bioavailability  Product  development Résumé : This study considered the design and process development of nanomized products in two product forms: nanoemulsion and nanodispersible solids. The effect of product formulation and processing conditions on product attributes such as particle size and appearance were studied using orange oil and Oil Red O as model compounds. The relationship between particle size and product quality in terms of bioactivity and bioavaflabflity was illustrated using schisandrin B, a strong antioxidant, as a model drug. The bioactivity as measured by in vivo glutathione regeneration capacity assay of schisandrin B with an average size of 45 nm was nearly double that of the original coarse schisandrin B; the corresponding bioavailability as measured by the plasma schisandrin B level in an animal study was 14.5-fold higher. ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=25948472