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Deproteinized natural rubber latex / hydroxypropylmethyl cellulose blending polymers for nicotine matrix films / Wiwat Pichayakorn in Industrial & engineering chemistry research, Vol. 51 N° 25 (Juin 2012) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 51 N° 25 (Juin 2012) . - pp. 8442-8452 Titre : Deproteinized natural rubber latex / hydroxypropylmethyl cellulose blending polymers for nicotine matrix films Type de document : texte imprimé Auteurs : Wiwat Pichayakorn, Auteur ; Jirapornchai Suksaeree, Auteur ; Prapaporn Boonme, Auteur Année de publication : 2012 Article en page(s) : pp. 8442-8452 Note générale : Industrial chemistry Langues : Anglais (eng) Mots-clés : Polymers  Nicotine Résumé : Nicotine matrix films were prepared using DNRL/HPMC blends for transdermal delivery. Several plasticizers were also mixed. The mechanical and physicochemical properties, moisture uptake, and swelling ratio of films depended on HPMC and plasticizers. The compatibility of each ingredient in the blended films was confirmed by FT-IR, XRD, and DSC. The in vitro release of nicotine showed a monophasic slow release pattern. The polymer and plasticizer blends produced a faster release rate. The kinetics of nicotine release from the films fitted the diffusion type. Surprisingly, the permeation of the nicotine into the skin occurred by zero-order kinetics. It was concluded that nicotine matrix films could be produced that could provide a controlled release of the drug and suitable permeation patterns. Moreover, they were safe to apply to the skin as they did not cause irritation. ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie300608j [article] Deproteinized natural rubber latex / hydroxypropylmethyl cellulose blending polymers for nicotine matrix films [texte imprimé] / Wiwat Pichayakorn, Auteur ; Jirapornchai Suksaeree, Auteur ; Prapaporn Boonme, Auteur . - 2012 . - pp. 8442-8452. Industrial chemistry Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 51 N° 25 (Juin 2012) . - pp. 8442-8452 Mots-clés : Polymers  Nicotine Résumé : Nicotine matrix films were prepared using DNRL/HPMC blends for transdermal delivery. Several plasticizers were also mixed. The mechanical and physicochemical properties, moisture uptake, and swelling ratio of films depended on HPMC and plasticizers. The compatibility of each ingredient in the blended films was confirmed by FT-IR, XRD, and DSC. The in vitro release of nicotine showed a monophasic slow release pattern. The polymer and plasticizer blends produced a faster release rate. The kinetics of nicotine release from the films fitted the diffusion type. Surprisingly, the permeation of the nicotine into the skin occurred by zero-order kinetics. It was concluded that nicotine matrix films could be produced that could provide a controlled release of the drug and suitable permeation patterns. Moreover, they were safe to apply to the skin as they did not cause irritation. ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie300608j

Preparation of deproteinized natural rubber latex and properties of films formed by itself and several adhesive polymer blends / Wiwat Pichayakorn in Industrial & engineering chemistry research, Vol. 51 N° 41 (Octobre 2012) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 51 N° 41 (Octobre 2012) . - pp. 13393–13404 Titre : Preparation of deproteinized natural rubber latex and properties of films formed by itself and several adhesive polymer blends Type de document : texte imprimé Auteurs : Wiwat Pichayakorn, Auteur ; Jirapornchai Suksaeree, Auteur ; Prapaporn Boonme, Auteur Année de publication : 2012 Article en page(s) : pp. 13393–13404 Note générale : Industrial chemistry Langues : Anglais (eng) Mots-clés : Polymer Résumé : This work aimed first to prepare deproteinized natural rubber latex (DNRL) and investigate the properties of films after it was blended with various adhesive polymers: hydroxypropylmethyl cellulose (HPMC), methyl cellulose (MC), sodium carboxymethyl cellulose (SCMC), poly(vinyl alcohol) (PVA), poloxamer 407, and sodium alginate. The second aim was to identify the films that would be the best for medical and pharmaceutical applications. Dibutyl phthalate (DBP), diethyl phthalate, dibutyl sebacate, triethyl citrate, and glycerin (GLY) were used as plasticizers to improve the elasticity and adhesiveness of the novel materials. DNRL was prepared by proteolytic alcalase enzyme treatment, followed by centrifugation. The DNRL was virtually free of protein, produced no significant reaction in the rabbit skin irritation test, and formed a good elastic film, but it had low skin adhesive properties. Blending DNRL with several polymers produced better films with different elastic and adhesive properties. Moisture uptake and swelling tests indicated that its films provided increasing hydrophilicity when blended with several polymers. SEM showed homogeneous films, and water hydraulic permeability tests indicated some porosity in matrix films. Blending DNRL with HPMC or PVA and DBP or GLY produced films with the best potential for novel materials. FT-IR, DSC, and XRD studies indicated the compatibility of the blended ingredients. In conclusion, DNRL blends could be used suitably for medical and pharmaceutical applications. ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie301985y [article] Preparation of deproteinized natural rubber latex and properties of films formed by itself and several adhesive polymer blends [texte imprimé] / Wiwat Pichayakorn, Auteur ; Jirapornchai Suksaeree, Auteur ; Prapaporn Boonme, Auteur . - 2012 . - pp. 13393–13404. Industrial chemistry Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 51 N° 41 (Octobre 2012) . - pp. 13393–13404 Mots-clés : Polymer Résumé : This work aimed first to prepare deproteinized natural rubber latex (DNRL) and investigate the properties of films after it was blended with various adhesive polymers: hydroxypropylmethyl cellulose (HPMC), methyl cellulose (MC), sodium carboxymethyl cellulose (SCMC), poly(vinyl alcohol) (PVA), poloxamer 407, and sodium alginate. The second aim was to identify the films that would be the best for medical and pharmaceutical applications. Dibutyl phthalate (DBP), diethyl phthalate, dibutyl sebacate, triethyl citrate, and glycerin (GLY) were used as plasticizers to improve the elasticity and adhesiveness of the novel materials. DNRL was prepared by proteolytic alcalase enzyme treatment, followed by centrifugation. The DNRL was virtually free of protein, produced no significant reaction in the rabbit skin irritation test, and formed a good elastic film, but it had low skin adhesive properties. Blending DNRL with several polymers produced better films with different elastic and adhesive properties. Moisture uptake and swelling tests indicated that its films provided increasing hydrophilicity when blended with several polymers. SEM showed homogeneous films, and water hydraulic permeability tests indicated some porosity in matrix films. Blending DNRL with HPMC or PVA and DBP or GLY produced films with the best potential for novel materials. FT-IR, DSC, and XRD studies indicated the compatibility of the blended ingredients. In conclusion, DNRL blends could be used suitably for medical and pharmaceutical applications. ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie301985y