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Continuous supercritical emulsions extraction / Nunzia Falco in Industrial & engineering chemistry research, Vol. 51 N° 25 (Juin 2012) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 51 N° 25 (Juin 2012) . - pp. 8616-8623 Titre : Continuous supercritical emulsions extraction : Packed tower characterization and application to poly (lactic-co-glycolic Acid) + insulin microspheres production Type de document : texte imprimé Auteurs : Nunzia Falco, Auteur ; Ernesto Reverchon, Auteur ; Giovanna Della Porta, Auteur Année de publication : 2012 Article en page(s) : pp. 8616-8623 Note générale : Industrial chemistry Langues : Anglais (eng) Mots-clés : Production  Microsphere  Packed  column  Emulsion  Supercritical  state Résumé : The continuous supercritical emulsions extraction (SEE-C) process uses a countercurrent packed tower for the continuous extraction of the organic solvents from emulsions. The continuous operation allows the formation of microspheres that are recovered at the bottom of the tower in the form of a water suspension, avoiding coalescence problems and batch-to-batch repeatability, typical of traditional processes. In this work, the packed tower used for SEE-C was characterized from a fluidodynamic point of view: flooding conditions and the allowable density difference were calculated from the experimental data. Then, an active principle (insulin) was tested for its encapsulation in poly(lactic-co-glycolic acid) (PLGA) microspheres, starting from a double emulsion: particle size, morphology, and encapsulation efficiency of the produced microdevices were evaluated. Spherical, not collapsed microspheres with a mean diameter between 1.8 μm (SD ± 0.9) and 4.8 μm (SD ± 2.8) and encapsulation efficiencies up to 70% were obtained. The very fast solvent extraction rate did not influence the particle morphology but had a significant effect on the size distribution of the precipitates which were always smaller than the starting droplets. A solvent residue (ethyl acetate) lower than about 600 ppm was obtained in all the experiments performed. ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=26066788 [article] Continuous supercritical emulsions extraction : Packed tower characterization and application to poly (lactic-co-glycolic Acid) + insulin microspheres production [texte imprimé] / Nunzia Falco, Auteur ; Ernesto Reverchon, Auteur ; Giovanna Della Porta, Auteur . - 2012 . - pp. 8616-8623. Industrial chemistry Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 51 N° 25 (Juin 2012) . - pp. 8616-8623 Mots-clés : Production  Microsphere  Packed  column  Emulsion  Supercritical  state Résumé : The continuous supercritical emulsions extraction (SEE-C) process uses a countercurrent packed tower for the continuous extraction of the organic solvents from emulsions. The continuous operation allows the formation of microspheres that are recovered at the bottom of the tower in the form of a water suspension, avoiding coalescence problems and batch-to-batch repeatability, typical of traditional processes. In this work, the packed tower used for SEE-C was characterized from a fluidodynamic point of view: flooding conditions and the allowable density difference were calculated from the experimental data. Then, an active principle (insulin) was tested for its encapsulation in poly(lactic-co-glycolic acid) (PLGA) microspheres, starting from a double emulsion: particle size, morphology, and encapsulation efficiency of the produced microdevices were evaluated. Spherical, not collapsed microspheres with a mean diameter between 1.8 μm (SD ± 0.9) and 4.8 μm (SD ± 2.8) and encapsulation efficiencies up to 70% were obtained. The very fast solvent extraction rate did not influence the particle morphology but had a significant effect on the size distribution of the precipitates which were always smaller than the starting droplets. A solvent residue (ethyl acetate) lower than about 600 ppm was obtained in all the experiments performed. ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=26066788