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Internal structure and size matters of polyester nanoparticles encapsulating a bioactive hydrophobic drug for the prevention of drug crystals in aqueous systems / Eun Chul Cho in Industrial & engineering chemistry research, Vol. 51 N° 34 (Août 2012) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 51 N° 34 (Août 2012) . - pp. 11137–11146 Titre : Internal structure and size matters of polyester nanoparticles encapsulating a bioactive hydrophobic drug for the prevention of drug crystals in aqueous systems Type de document : texte imprimé Auteurs : Eun Chul Cho, Auteur Année de publication : 2012 Article en page(s) : pp. 11137–11146 Note générale : Industrial chemistry Langues : Anglais (eng) Mots-clés : Nanoparticles  Bioactive  Hydrophobic Résumé : This study presents a way of preventing a highly hydrophobic bioactive drug encapsulated in polycaprolactone (PCL) nanoparticles from forming drug crystals aqueous systems. Thymol trimethoxycinnamate was selected as a hydrophobic bioactive model drug. Four PCL-drug nanoparticles were prepared: their internal structures and sizes were regulated by introducing different types of PCL or by changing polymer compositions during the preparation of the nanoparticles. The formation of drug crystals from the PCL-drug nanoparticles was observed by optical microscopy at two temperatures (25 and 40 °C) and in three aqueous mediums (deionized water or aqueous solutions containing 5 wt % butylene glycol or ethanol). In deionized water, the formation of drug crystals could be prevented if PCL-drug nanoparticles have highly crystalline cores. In aqueous solutions containing butylene glycol or ethanol, both the internal crystalline core and the size of the nanoparticles could be important in preventing the drug crystal formation. The present study provides both scientific and practical information to those who involve the drug delivery system and pharmaceutical sciences where drugs are engineered to increase the therapeutic efficiency through polymeric nanoparticles. ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie300573q [article] Internal structure and size matters of polyester nanoparticles encapsulating a bioactive hydrophobic drug for the prevention of drug crystals in aqueous systems [texte imprimé] / Eun Chul Cho, Auteur . - 2012 . - pp. 11137–11146. Industrial chemistry Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 51 N° 34 (Août 2012) . - pp. 11137–11146 Mots-clés : Nanoparticles  Bioactive  Hydrophobic Résumé : This study presents a way of preventing a highly hydrophobic bioactive drug encapsulated in polycaprolactone (PCL) nanoparticles from forming drug crystals aqueous systems. Thymol trimethoxycinnamate was selected as a hydrophobic bioactive model drug. Four PCL-drug nanoparticles were prepared: their internal structures and sizes were regulated by introducing different types of PCL or by changing polymer compositions during the preparation of the nanoparticles. The formation of drug crystals from the PCL-drug nanoparticles was observed by optical microscopy at two temperatures (25 and 40 °C) and in three aqueous mediums (deionized water or aqueous solutions containing 5 wt % butylene glycol or ethanol). In deionized water, the formation of drug crystals could be prevented if PCL-drug nanoparticles have highly crystalline cores. In aqueous solutions containing butylene glycol or ethanol, both the internal crystalline core and the size of the nanoparticles could be important in preventing the drug crystal formation. The present study provides both scientific and practical information to those who involve the drug delivery system and pharmaceutical sciences where drugs are engineered to increase the therapeutic efficiency through polymeric nanoparticles. ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie300573q