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Semi - IPN chitosan / PEG microspheres and films for biomedical applications / Ismail Dogan Gunbas in Industrial & engineering chemistry research, Vol. 51 N° 37 (Septembre 2012) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 51 N° 37 (Septembre 2012) . - pp. 11946–11954 Titre : Semi - IPN chitosan / PEG microspheres and films for biomedical applications : Characterization and sustained release optimization Type de document : texte imprimé Auteurs : Ismail Dogan Gunbas, Auteur ; Umran Aydemir Sezer, Auteur ; Sultan Gulce iz, Auteur Année de publication : 2012 Article en page(s) : pp. 11946–11954 Note générale : Industrial chemistry Langues : Anglais (eng) Mots-clés : Microspheres  Optimization Résumé : Micro drug carriers are one of the efficient methods for local or systemic cancer treatment. In this study, the aim was to prepare a novel semi-interpenetrated (semi-IPN) micro system by using biocompatible chitosan (CH) and polyethylene glycol (PEG). Various combinations of the systems were prepared and loaded with a model chemotherapeutic drug, methotrexate (MTX), and the effects of composition on the properties and the release behavior of microspheres were examined. Also, the mechanical and thermal properties were examined on film forms of similar compositions. Increase in cross-linking caused a decrease in particle size of CH from 144 to 91 μm, while the addition of PEG caused an increase up to 163 μm. Elastic modulus values of the films first increased and then decreased parallel to PEG content. In vitro studies showed faster MTX release from semi-IPN CH-PEG microspheres as compared to pure CH ones. Promising results were obtained in the development of biodegradable drug vehicles. ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie3015523 [article] Semi - IPN chitosan / PEG microspheres and films for biomedical applications : Characterization and sustained release optimization [texte imprimé] / Ismail Dogan Gunbas, Auteur ; Umran Aydemir Sezer, Auteur ; Sultan Gulce iz, Auteur . - 2012 . - pp. 11946–11954. Industrial chemistry Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 51 N° 37 (Septembre 2012) . - pp. 11946–11954 Mots-clés : Microspheres  Optimization Résumé : Micro drug carriers are one of the efficient methods for local or systemic cancer treatment. In this study, the aim was to prepare a novel semi-interpenetrated (semi-IPN) micro system by using biocompatible chitosan (CH) and polyethylene glycol (PEG). Various combinations of the systems were prepared and loaded with a model chemotherapeutic drug, methotrexate (MTX), and the effects of composition on the properties and the release behavior of microspheres were examined. Also, the mechanical and thermal properties were examined on film forms of similar compositions. Increase in cross-linking caused a decrease in particle size of CH from 144 to 91 μm, while the addition of PEG caused an increase up to 163 μm. Elastic modulus values of the films first increased and then decreased parallel to PEG content. In vitro studies showed faster MTX release from semi-IPN CH-PEG microspheres as compared to pure CH ones. Promising results were obtained in the development of biodegradable drug vehicles. ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie3015523