Self - assembled nanoparticles from thermo - sensitive polyion complex micelles for controlled drug release / Guiying Li in Chemical engineering journal, Vol. 174 N° 1 (Octobre 2011)  

Public ISBD [article]  inChemical engineering journal > Vol. 174 N° 1 (Octobre 2011) . - pp. 199–205 Titre : Self - assembled nanoparticles from thermo - sensitive polyion complex micelles for controlled drug release Type de document : texte imprimé Auteurs : Guiying Li, Auteur ; Lei Guo, Auteur ; Yanfeng Meng, Auteur Année de publication : 2012 Article en page(s) : pp. 199–205 Note générale : Génie chimique Langues : Anglais (eng) Mots-clés : Controlled release Polyion complex micelles Nanoparticles CS -g - PNIPAM P(tBA co AA)- b Résumé : Self-assembled nanoparticles from thermo-sensitive polyion complex (PIC) micelles comprised of poly(t-butyl acrylate-co-acrylic acid)-b-poly(N-isopropylacrylamide) [P(tBA-co-AA)-b-PNIPAM] core–shell micelles and graft copolymer chitosan-g-poly(N-isopropylacrylamide) (CS-g-PNIPAM) were developed for applications in controlled drug release. The PIC micelles nanoparticles had a multi-layer core–shell–corona structure with hydrophobic PtBA as the inner core, negatively charged PAA and positively charged CS forming the middle layer as the shell, and thermo-sensitive PNIPAM as the outer corona. The molar ratio of P(tBA-co-AA)-b-PNIPAM to CS-g-PNIPAM affected the functionalities and hydrodynamic diameters of nanoparticles. Release of doxorubicin (DOX) from micelles was suppressed at neutral solutions due to the stability of electrostatic interactions but accelerated at acidic solutions or high temperatures above LCST. This study presents new micelles with a functional inner shell whose structure can be rapidly damaged to release charged drugs when the microenvironment of micelles changed. ISSN : 1385-8947 En ligne : http://www.sciencedirect.com/science/article/pii/S1385894711010540 [article] Self - assembled nanoparticles from thermo - sensitive polyion complex micelles for controlled drug release [texte imprimé] / Guiying Li, Auteur ; Lei Guo, Auteur ; Yanfeng Meng, Auteur . - 2012 . - pp. 199–205. Génie chimique Langues : Anglais (eng) in Chemical engineering journal > Vol. 174 N° 1 (Octobre 2011) . - pp. 199–205 Mots-clés : Controlled release Polyion complex micelles Nanoparticles CS -g - PNIPAM P(tBA co AA)- b Résumé : Self-assembled nanoparticles from thermo-sensitive polyion complex (PIC) micelles comprised of poly(t-butyl acrylate-co-acrylic acid)-b-poly(N-isopropylacrylamide) [P(tBA-co-AA)-b-PNIPAM] core–shell micelles and graft copolymer chitosan-g-poly(N-isopropylacrylamide) (CS-g-PNIPAM) were developed for applications in controlled drug release. The PIC micelles nanoparticles had a multi-layer core–shell–corona structure with hydrophobic PtBA as the inner core, negatively charged PAA and positively charged CS forming the middle layer as the shell, and thermo-sensitive PNIPAM as the outer corona. The molar ratio of P(tBA-co-AA)-b-PNIPAM to CS-g-PNIPAM affected the functionalities and hydrodynamic diameters of nanoparticles. Release of doxorubicin (DOX) from micelles was suppressed at neutral solutions due to the stability of electrostatic interactions but accelerated at acidic solutions or high temperatures above LCST. This study presents new micelles with a functional inner shell whose structure can be rapidly damaged to release charged drugs when the microenvironment of micelles changed. ISSN : 1385-8947 En ligne : http://www.sciencedirect.com/science/article/pii/S1385894711010540

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