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Combined application of in Situ FBRM, ATR-FTIR, and raman on polymorphism transformation monitoring during the cooling crystallization / Yingying Zhao in Industrial & engineering chemistry research, Vol. 51 N° 38 (Septembre 2012) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 51 N° 38 (Septembre 2012) . - pp. 12530-12536 Titre : Combined application of in Situ FBRM, ATR-FTIR, and raman on polymorphism transformation monitoring during the cooling crystallization Type de document : texte imprimé Auteurs : Yingying Zhao, Auteur ; Junsheng Yuan, Auteur ; Zhiyong Ji, Auteur Année de publication : 2012 Article en page(s) : pp. 12530-12536 Note générale : Industrial chemistry Langues : Anglais (eng) Mots-clés : Crystallization  Cooling  Surveillance  Polymorphism  In  situ Résumé : This study evaluates the potential use of the FBRM, ATR-FTIR, and Raman for on line detection of polymorphic transformation of carbamazepine (CBZ) during the cooling crystallization. Changes in solution concentration as a function of time were quantified from the ATR-FTIR data. A new quantitative method of polymorphs ratio was developed using Raman spectroscopy for in situ monitoring during a solution-mediated transformation of carbamazepine from form II to form III in 1-propanol. The polymorphic forms initially crystallized from solution, in the absence of seeds, could be clearly identified by FBRM and showed good agreement with results of microscopic images. Furthermore, the kinetics of the conversion of carbamazepine from metastable form to the stable form at different cooling rates could be readily followed. ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=26399705 [article] Combined application of in Situ FBRM, ATR-FTIR, and raman on polymorphism transformation monitoring during the cooling crystallization [texte imprimé] / Yingying Zhao, Auteur ; Junsheng Yuan, Auteur ; Zhiyong Ji, Auteur . - 2012 . - pp. 12530-12536. Industrial chemistry Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 51 N° 38 (Septembre 2012) . - pp. 12530-12536 Mots-clés : Crystallization  Cooling  Surveillance  Polymorphism  In  situ Résumé : This study evaluates the potential use of the FBRM, ATR-FTIR, and Raman for on line detection of polymorphic transformation of carbamazepine (CBZ) during the cooling crystallization. Changes in solution concentration as a function of time were quantified from the ATR-FTIR data. A new quantitative method of polymorphs ratio was developed using Raman spectroscopy for in situ monitoring during a solution-mediated transformation of carbamazepine from form II to form III in 1-propanol. The polymorphic forms initially crystallized from solution, in the absence of seeds, could be clearly identified by FBRM and showed good agreement with results of microscopic images. Furthermore, the kinetics of the conversion of carbamazepine from metastable form to the stable form at different cooling rates could be readily followed. ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=26399705