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Polymorphic crystallization and transformation of candesartan cilexetil / Penglei Cui in Industrial & engineering chemistry research, Vol. 51 N° 39 (Octobre 2012) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 51 N° 39 (Octobre 2012) . - pp. 12910–12916 Titre : Polymorphic crystallization and transformation of candesartan cilexetil Type de document : texte imprimé Auteurs : Penglei Cui, Auteur ; Qiuxiang Yin, Auteur ; Yuhong Guo, Auteur Année de publication : 2012 Article en page(s) : pp. 12910–12916 Note générale : Industrial chemistry Langues : Anglais (eng) Mots-clés : Crystallization  Candesartan  cilexetil Résumé : In this paper, the acetone solvate of candesartan cilexetil was preferentially crystallized from the acetone solution by cooling crystallization and was characterized by combination methods of X-ray powder diffraction (XRPD), 13C nuclear magnetic resonance (NMR), thermogravimetric analysis/differential scanning calorimetry (TGA/DSC), Forier transform infrared (FTIR), Raman spectroscopy, and dynamic vapor sorption (DVS). The polymorphic transformation among two polymorphs (form I and form II) and acetone solvates of candesartan cilexetil was investigated, respectively. By regulating the initial solution concentration and composition of solvent mixture (water/acetone), form I or acetone solvate could be obtained. With the aid of in situ Raman spectroscopy, the kinetics of solvent-mediated transformation (form II → acetone solvate) and solid-state transition (acetone solvate → form II) were systematically studied at different temperatures. The results show that the mechanism of solid-state transformation of acetone solvate to form II depends on one-dimensional diffusion. ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie2024855 [article] Polymorphic crystallization and transformation of candesartan cilexetil [texte imprimé] / Penglei Cui, Auteur ; Qiuxiang Yin, Auteur ; Yuhong Guo, Auteur . - 2012 . - pp. 12910–12916. Industrial chemistry Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 51 N° 39 (Octobre 2012) . - pp. 12910–12916 Mots-clés : Crystallization  Candesartan  cilexetil Résumé : In this paper, the acetone solvate of candesartan cilexetil was preferentially crystallized from the acetone solution by cooling crystallization and was characterized by combination methods of X-ray powder diffraction (XRPD), 13C nuclear magnetic resonance (NMR), thermogravimetric analysis/differential scanning calorimetry (TGA/DSC), Forier transform infrared (FTIR), Raman spectroscopy, and dynamic vapor sorption (DVS). The polymorphic transformation among two polymorphs (form I and form II) and acetone solvates of candesartan cilexetil was investigated, respectively. By regulating the initial solution concentration and composition of solvent mixture (water/acetone), form I or acetone solvate could be obtained. With the aid of in situ Raman spectroscopy, the kinetics of solvent-mediated transformation (form II → acetone solvate) and solid-state transition (acetone solvate → form II) were systematically studied at different temperatures. The results show that the mechanism of solid-state transformation of acetone solvate to form II depends on one-dimensional diffusion. ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie2024855