Carboxymethyl chitosan-functionalized magnetic nanoparticles for disruption of biofilms of staphylococcus aureus and escherichia coli / Tong Chen in Industrial & engineering chemistry research, Vol. 51 N° 40 (Octobre 2012)  

Public ISBD [article]  inIndustrial & engineering chemistry research > Vol. 51 N° 40 (Octobre 2012) . - pp. 13164-13172 Titre : Carboxymethyl chitosan-functionalized magnetic nanoparticles for disruption of biofilms of staphylococcus aureus and escherichia coli Type de document : texte imprimé Auteurs : Tong Chen, Auteur ; Rong Wang, Auteur ; Li Qun Xu, Auteur Année de publication : 2012 Article en page(s) : pp. 13164-13172 Note générale : Industrial chemistry Langues : Anglais (eng) Mots-clés : Bacteria Enterobacteriaceae Escherichia coli Biofil Disruption Nanoparticle Résumé : Bacteria in biofilms are much more resistant to antibiotics and microbicides as compared to their planktonic stage. Thus, to achieve the same antibacterial efficacy, a much higher dose of antibiotics is required for-biofilm bacteria. However, the widespread use of antibiotics has been recognized as the main cause for the emergence of antibiotic-resistant microbial species, which has now become a major public health crisis globally. In this work, we present an efficient nonantibiotic-based strategy for disrupting biofilms using carboxymethyl chitosan (CMCS) coated on magnetic iron oxide nanoparticles (CMCS-MNPs). CMCS-MNPs demonstrate strong bactericidal activities against both Gram-positive Staphylococcus aureus (S. aureus) and Gram-negative Escherichia coli (E. coli) planktonic cells. More than 99% S. aureus and E. coli planktonic cells were killed after incubation with CMCS-MNPs for 10 and 5 h, respectively. In the presence of a magnetic field (MF), CMCS-MNPs can effectively penetrate into both S. aureus and E. coli biofilms, resulting in a reduction of viable cells counts by 84% and 95%, respectively, after 48 h incubation, as compared to the control experiment without CMCS-MNPs or CMCS. CMCS-MNPs are noncytotoxic toward mammalian cells and can potentially be a useful antimicrobial agent to eliminate both planktonic and biofilm bacteria. ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=26451466 [article] Carboxymethyl chitosan-functionalized magnetic nanoparticles for disruption of biofilms of staphylococcus aureus and escherichia coli [texte imprimé] / Tong Chen, Auteur ; Rong Wang, Auteur ; Li Qun Xu, Auteur . - 2012 . - pp. 13164-13172. Industrial chemistry Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 51 N° 40 (Octobre 2012) . - pp. 13164-13172 Mots-clés : Bacteria Enterobacteriaceae Escherichia coli Biofil Disruption Nanoparticle Résumé : Bacteria in biofilms are much more resistant to antibiotics and microbicides as compared to their planktonic stage. Thus, to achieve the same antibacterial efficacy, a much higher dose of antibiotics is required for-biofilm bacteria. However, the widespread use of antibiotics has been recognized as the main cause for the emergence of antibiotic-resistant microbial species, which has now become a major public health crisis globally. In this work, we present an efficient nonantibiotic-based strategy for disrupting biofilms using carboxymethyl chitosan (CMCS) coated on magnetic iron oxide nanoparticles (CMCS-MNPs). CMCS-MNPs demonstrate strong bactericidal activities against both Gram-positive Staphylococcus aureus (S. aureus) and Gram-negative Escherichia coli (E. coli) planktonic cells. More than 99% S. aureus and E. coli planktonic cells were killed after incubation with CMCS-MNPs for 10 and 5 h, respectively. In the presence of a magnetic field (MF), CMCS-MNPs can effectively penetrate into both S. aureus and E. coli biofilms, resulting in a reduction of viable cells counts by 84% and 95%, respectively, after 48 h incubation, as compared to the control experiment without CMCS-MNPs or CMCS. CMCS-MNPs are noncytotoxic toward mammalian cells and can potentially be a useful antimicrobial agent to eliminate both planktonic and biofilm bacteria. ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=26451466

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