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Structure/property relationship for ethylenediamine derivatives as aids in sunless tanning / J. O. Carnali in Industrial & engineering chemistry research, Vol. 51 N° 48 (Décembre 2012) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 51 N° 48 (Décembre 2012) . - pp. 15573-15581 Titre : Structure/property relationship for ethylenediamine derivatives as aids in sunless tanning Type de document : texte imprimé Auteurs : J. O. Carnali, Auteur ; S. A. Madison, Auteur ; P. Shah, Auteur Année de publication : 2013 Article en page(s) : pp. 15573-15581 Note générale : Industrial chemistry Langues : Anglais (eng) Mots-clés : Property  structure  relationship Résumé : This report covers an effort to identify adjuvants to the sunless tanning action of dihydroxyacetone. The readily available derivatives of ethylenediamine were systematically studied for their coloration behavior with DHA on synthetic skin, resulting in the following structure/activity relationship: 1) Linear derivatives with each of the amines either primary or secondary with respect to methyl substitution gave very rapid coloration, as did cyclic derivatives in which the ethylenediamine backbone was fully embedded in the ring and both amines are primary or partially embedded with the external amine primary; 2) Stretched derivatives in which the ethylene moiety is changed to propylene or longer gave progressively less coloration; 3) Derivatives of ethylenediamine in which either or both of the amines were tertiary with respect to alkyl substitution yielded no adjuvant action. The observed behavior can be rationalized in terms of the Maillard reaction being a complex network of reactions in which the chemical structure of the adjuvant controls, at least in part, the reaction pathway. For ethylenediamines, it appears that a highly reactive pathway exists which involves a six-membered ring with the amine groups at the 1,4 positions. Thus stretched diamines and tertiary amines are restricted from taking this route. ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=26710595 [article] Structure/property relationship for ethylenediamine derivatives as aids in sunless tanning [texte imprimé] / J. O. Carnali, Auteur ; S. A. Madison, Auteur ; P. Shah, Auteur . - 2013 . - pp. 15573-15581. Industrial chemistry Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 51 N° 48 (Décembre 2012) . - pp. 15573-15581 Mots-clés : Property  structure  relationship Résumé : This report covers an effort to identify adjuvants to the sunless tanning action of dihydroxyacetone. The readily available derivatives of ethylenediamine were systematically studied for their coloration behavior with DHA on synthetic skin, resulting in the following structure/activity relationship: 1) Linear derivatives with each of the amines either primary or secondary with respect to methyl substitution gave very rapid coloration, as did cyclic derivatives in which the ethylenediamine backbone was fully embedded in the ring and both amines are primary or partially embedded with the external amine primary; 2) Stretched derivatives in which the ethylene moiety is changed to propylene or longer gave progressively less coloration; 3) Derivatives of ethylenediamine in which either or both of the amines were tertiary with respect to alkyl substitution yielded no adjuvant action. The observed behavior can be rationalized in terms of the Maillard reaction being a complex network of reactions in which the chemical structure of the adjuvant controls, at least in part, the reaction pathway. For ethylenediamines, it appears that a highly reactive pathway exists which involves a six-membered ring with the amine groups at the 1,4 positions. Thus stretched diamines and tertiary amines are restricted from taking this route. ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=26710595