Chemical composition and in vitro cytotoxic activity of xylopia aethiopica (Dun) A. rich. (Annonaceae) fruit essential oil from Togo / Koffi Koba in The journal of essential oil research, Vol. 20 n°4 (Juillet/Août 2008)  

Public ISBD [article]  inThe journal of essential oil research > Vol. 20 n°4 (Juillet/Août 2008) . - pp. 354-357 Titre : Chemical composition and in vitro cytotoxic activity of xylopia aethiopica (Dun) A. rich. (Annonaceae) fruit essential oil from Togo Type de document : texte imprimé Auteurs : Koffi Koba, Auteur ; Komla Sanda, Auteur ; Christine Raynaud, Auteur Année de publication : 2008 Article en page(s) : pp. 354-357 Note générale : Génie Chimique Langues : Anglais (eng) Mots-clés : Xylopia aethiopica Essential oil β  -pinene α  -pinene HaCat cell line Cytotoxicity Résumé : Essential oil extracted (4.4% in yield) from air-dried fruits of Xylopia aethiopica harvested in Togo was investigated for percentage composition and in vitro cytotoxicity. The chemical composition of the essential oil was examined by GC and GC/MS. Thirty-five compounds were identified representing 89.9% of total oil. The major constituents were β-pinene (23.6%), α-pinene (11%), sabinene (9.8%), germacrene D (8.3%) and 1,8 cineole (8.2%). The cytotoxicity of the volatile oil was evaluated in vitro on the human epidermal cell line HaCaT. The tested sample did not show any cytotoxicity (IC50 >3000 μg.ml-1) effect at concentrations around 3000 μg.ml-1. Further testing in bioassay would probably help in validating some of medicinal uses of X. aethiopica in topical drugs and/or in cosmetics as natural products. ISSN : 1041-2905 En ligne : http://www.tandfonline.com/doi/abs/10.1080/10412905.2008.9700029 [article] Chemical composition and in vitro cytotoxic activity of xylopia aethiopica (Dun) A. rich. (Annonaceae) fruit essential oil from Togo [texte imprimé] / Koffi Koba, Auteur ; Komla Sanda, Auteur ; Christine Raynaud, Auteur . - 2008 . - pp. 354-357. Génie Chimique Langues : Anglais (eng) in The journal of essential oil research > Vol. 20 n°4 (Juillet/Août 2008) . - pp. 354-357 Mots-clés : Xylopia aethiopica Essential oil β  -pinene α  -pinene HaCat cell line Cytotoxicity Résumé : Essential oil extracted (4.4% in yield) from air-dried fruits of Xylopia aethiopica harvested in Togo was investigated for percentage composition and in vitro cytotoxicity. The chemical composition of the essential oil was examined by GC and GC/MS. Thirty-five compounds were identified representing 89.9% of total oil. The major constituents were β-pinene (23.6%), α-pinene (11%), sabinene (9.8%), germacrene D (8.3%) and 1,8 cineole (8.2%). The cytotoxicity of the volatile oil was evaluated in vitro on the human epidermal cell line HaCaT. The tested sample did not show any cytotoxicity (IC50 >3000 μg.ml-1) effect at concentrations around 3000 μg.ml-1. Further testing in bioassay would probably help in validating some of medicinal uses of X. aethiopica in topical drugs and/or in cosmetics as natural products. ISSN : 1041-2905 En ligne : http://www.tandfonline.com/doi/abs/10.1080/10412905.2008.9700029

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