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A seasonal variation study of the chemical composition and antimicrobial activity of the essential oil of Agathosma ovata (Thunb.) pillans (Rutaceae) / Alvaro M. Viljoen in The journal of essential oil research, Vol. 18 N° Spécial (Juillet 2006) 

Public ISBD [article]  in The journal of essential oil research > Vol. 18 N° Spécial (Juillet 2006) . - pp. 30-36 Titre : A seasonal variation study of the chemical composition and antimicrobial activity of the essential oil of Agathosma ovata (Thunb.) pillans (Rutaceae) Type de document : texte imprimé Auteurs : Alvaro M. Viljoen, Auteur ; Aneesa Moolla, Auteur ; Sandy F. Van Vuuren, Auteur Année de publication : 2013 Article en page(s) : pp. 30-36 Note générale : Génie Chimique Langues : Anglais (eng) Mots-clés : Agathosnw  ovata  Rutaceae  Buchu  Essential  oil  composition  Sabinene  p-cymene  Terpinen-4-ol  α-pinene  α-  thujene  Myrcene  Limonene  Linalool  Antimicrobial  activity Résumé : A seasonal variation study was performed on the chemical composition of the essential oil of Agathosma ovata (Rutaceae). In addition, this study looked at how variations may impact the antimicrobial activity of A. ovata. The chemical composition of 10 monthly samples, as determined by GC and GC/MS, were found to differ qualitatively and quantitatively and the analysis resulted in the identification of 144 compounds. Sabinene was the major compound in the oil and ranged between 25-44% over the year. The antimicrobial activity was evaluated using the minimum inhibitory concentration (MIC) method on four pathogens, i.e. Staphylococcus aureus, Bacillus cereus, Klebsiella pneumoniae and Candida albicans. Most ofthe samples had MIC values of 8 mg/mL. The activity for Staphylococcus aureus showed the greatest fluctuation (1.5-14 mg/mL) over the seasonal period. ISSN : 1041-2905 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=18019078 [article] A seasonal variation study of the chemical composition and antimicrobial activity of the essential oil of Agathosma ovata (Thunb.) pillans (Rutaceae) [texte imprimé] / Alvaro M. Viljoen, Auteur ; Aneesa Moolla, Auteur ; Sandy F. Van Vuuren, Auteur . - 2013 . - pp. 30-36. Génie Chimique Langues : Anglais (eng) in The journal of essential oil research > Vol. 18 N° Spécial (Juillet 2006) . - pp. 30-36 Mots-clés : Agathosnw  ovata  Rutaceae  Buchu  Essential  oil  composition  Sabinene  p-cymene  Terpinen-4-ol  α-pinene  α-  thujene  Myrcene  Limonene  Linalool  Antimicrobial  activity Résumé : A seasonal variation study was performed on the chemical composition of the essential oil of Agathosma ovata (Rutaceae). In addition, this study looked at how variations may impact the antimicrobial activity of A. ovata. The chemical composition of 10 monthly samples, as determined by GC and GC/MS, were found to differ qualitatively and quantitatively and the analysis resulted in the identification of 144 compounds. Sabinene was the major compound in the oil and ranged between 25-44% over the year. The antimicrobial activity was evaluated using the minimum inhibitory concentration (MIC) method on four pathogens, i.e. Staphylococcus aureus, Bacillus cereus, Klebsiella pneumoniae and Candida albicans. Most ofthe samples had MIC values of 8 mg/mL. The activity for Staphylococcus aureus showed the greatest fluctuation (1.5-14 mg/mL) over the seasonal period. ISSN : 1041-2905 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=18019078

The biological activity and essential oil composition of 17 agathosma (Rutaceae) species / Alvaro M. Viljoen in The journal of essential oil research, Vol. 18 N° Spécial (Juillet 2006) 

Public ISBD [article]  in The journal of essential oil research > Vol. 18 N° Spécial (Juillet 2006) . - pp. 2-16 Titre : The biological activity and essential oil composition of 17 agathosma (Rutaceae) species Type de document : texte imprimé Auteurs : Alvaro M. Viljoen, Auteur ; Aneesa Moolla, Auteur ; Sandy F. Van Vuuren, Auteur Année de publication : 2013 Article en page(s) : pp. 2-16 Note générale : Génie Chimique Langues : Anglais (eng) Mots-clés : Agathosma  arida  Agathosma  bathii  Agathosma  hetulina  Agathosma  capensis  Agathosnw  collina  Agathosma  crenulata  Agathosnw  hirsuta  Agathosma  lanata  Agathosnw  namaquensis  Agathosma  ovalifolia  Agathosma  ovata  Agathosnw  parva  Agathosma  pubigera  Agathosma  pungens  Agathosnw  roodebergensis  Agathosma  stipitata  Agathosma  zwarthergense  Rutaceae  Buchu  Essential  oil  composition  Sabinene  Linalool  β-pinene  Menthone  Isomenthone  Pulegone  Myrcene  Limonene  p-phellandrene  Neral  Geranial  α-pinene  1,8-cineole  Citronellal  Linalool  Methyl  citronellate  Antimicrobial  activity  Anti-inflammatory  Toxicity Résumé : The essential oil composition, antimicrobial, anti-inflammatory and cytotoxic activities of 17 indigenous Agathosnw species (18 samples) were investigated in order to validate their use in traditional healing. The results were related to the chemical composition of the essential oils as determined by GC and GC/MS. The antimicrobial activity was evaluated using the minimum inhibitory concentration (MIC) method on four pathogens: Staphylococcus aureus (ATCC 12600), Bacillus cereus (ATCC 11778), Klebsiella pneumoniae (NCTC 9633) and Candida albicans (ATCC 10231). The anti-inflammatory activity was evaluated using the 5-lipoxygenase assay while the cytotoxic activity was determined using the MTT (3-[4,5-dimethyl-2-thiazol-yl]-2,5-diphenyl-2H-tetrazolium bromide) cellular viability assay. The antimicrobial assay revealed that the most active oil against C. albicans was A. collina (MIC value of 3 mg/mL) whilst the most active oils against B. cereus were A. crenulata and A. pungens (MIC values of 3 mg/mL). Nine of the species had MIC values of 4 mg/mL against the Gram-positive pathogen S. aureus. The oils showed less activity against the Gram-negative pathogen K pneumoniae. All the oils exhibited good in vitro anti-inflammatory activity with A. collina being the most potent (IC50 value of 25.98 ± 1.83 μg/mL). The results show that the oils were strong inhibitors of the enzyme 5-lipoxygenase. The oils proved to be toxic in the MTT assay displaying IC50 values of < 0.0001 μg/mL, which were relatively toxic when compared to a plant-derived compound such as quinine (IC50 value of 0.08 ± 0.03 μg/mL). The results revealed some relationships between the major components, some bioactivities and toxicities. The oils were found to differ qualitatively and quantitatively in compositions and their analysis resulted in the identification of a total of 322 compounds in 18 of the samples. ISSN : 1041-2905 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=18019074 [article] The biological activity and essential oil composition of 17 agathosma (Rutaceae) species [texte imprimé] / Alvaro M. Viljoen, Auteur ; Aneesa Moolla, Auteur ; Sandy F. Van Vuuren, Auteur . - 2013 . - pp. 2-16. Génie Chimique Langues : Anglais (eng) in The journal of essential oil research > Vol. 18 N° Spécial (Juillet 2006) . - pp. 2-16 Mots-clés : Agathosma  arida  Agathosma  bathii  Agathosma  hetulina  Agathosma  capensis  Agathosnw  collina  Agathosma  crenulata  Agathosnw  hirsuta  Agathosma  lanata  Agathosnw  namaquensis  Agathosma  ovalifolia  Agathosma  ovata  Agathosnw  parva  Agathosma  pubigera  Agathosma  pungens  Agathosnw  roodebergensis  Agathosma  stipitata  Agathosma  zwarthergense  Rutaceae  Buchu  Essential  oil  composition  Sabinene  Linalool  β-pinene  Menthone  Isomenthone  Pulegone  Myrcene  Limonene  p-phellandrene  Neral  Geranial  α-pinene  1,8-cineole  Citronellal  Linalool  Methyl  citronellate  Antimicrobial  activity  Anti-inflammatory  Toxicity Résumé : The essential oil composition, antimicrobial, anti-inflammatory and cytotoxic activities of 17 indigenous Agathosnw species (18 samples) were investigated in order to validate their use in traditional healing. The results were related to the chemical composition of the essential oils as determined by GC and GC/MS. The antimicrobial activity was evaluated using the minimum inhibitory concentration (MIC) method on four pathogens: Staphylococcus aureus (ATCC 12600), Bacillus cereus (ATCC 11778), Klebsiella pneumoniae (NCTC 9633) and Candida albicans (ATCC 10231). The anti-inflammatory activity was evaluated using the 5-lipoxygenase assay while the cytotoxic activity was determined using the MTT (3-[4,5-dimethyl-2-thiazol-yl]-2,5-diphenyl-2H-tetrazolium bromide) cellular viability assay. The antimicrobial assay revealed that the most active oil against C. albicans was A. collina (MIC value of 3 mg/mL) whilst the most active oils against B. cereus were A. crenulata and A. pungens (MIC values of 3 mg/mL). Nine of the species had MIC values of 4 mg/mL against the Gram-positive pathogen S. aureus. The oils showed less activity against the Gram-negative pathogen K pneumoniae. All the oils exhibited good in vitro anti-inflammatory activity with A. collina being the most potent (IC50 value of 25.98 ± 1.83 μg/mL). The results show that the oils were strong inhibitors of the enzyme 5-lipoxygenase. The oils proved to be toxic in the MTT assay displaying IC50 values of < 0.0001 μg/mL, which were relatively toxic when compared to a plant-derived compound such as quinine (IC50 value of 0.08 ± 0.03 μg/mL). The results revealed some relationships between the major components, some bioactivities and toxicities. The oils were found to differ qualitatively and quantitatively in compositions and their analysis resulted in the identification of a total of 322 compounds in 18 of the samples. ISSN : 1041-2905 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=18019074