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Détail de l'auteur
Auteur Sandy F. Van Vuuren
Documents disponibles écrits par cet auteur
Affiner la rechercheBiological activities and composition of Salvia muirii L. bol. essential oil / Guy P. P. Kamatou in The journal of essential oil research, Vol. 18 N° Spécial (Juillet 2006)
in The journal of essential oil research > Vol. 18 N° Spécial (Juillet 2006) . - pp. 48-51
Titre : Biological activities and composition of Salvia muirii L. bol. essential oil Type de document : texte imprimé Auteurs : Guy P. P. Kamatou, Auteur ; Robyn L. Vanzyl, Auteur ; Sandy F. Van Vuuren, Auteur Année de publication : 2013 Article en page(s) : pp. 48-51 Note générale : Génie Chimique Langues : Anglais (eng) Mots-clés : Salvia muirii Lamiaceae Biological activities Essential oil composition α-pinene 1,8-cineole Limonene Antimicrobial activity Anti-inflammatory activity Antimalarial activity Antioxidant activity Toxicity Résumé : The essential oil of Salvia muirii L. Bol., a species indigenous to southern Africa was obtained by hydrodistillation (0.5%, v/f.w.) from the aerial parts and analyzed by GC and GC/MS. Thirty-nine components representing 98% of the oil were identified. The oil was dominated by monoterpene hydrocarbons (53%) and oxygen-containing monoterpenes (36%) with 1,8-cineole (23%), α-pinene (22%) and limonene (12%) being the major components. The oil exhibited potent antimalarial (IC50: 6μg/mL) and antibacterial activity especially against Klebsiella pneumoniae and Bacillus cereus with MIC values of 6 and 9mg/mL, respectively. The oil exhibited poor anti-inflammatory and antioxidant activity. The 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide toxicity assay revealed that the essential oil of S. muirii should be used with caution as it displayed some degree of toxicity against the transformed human kidney epithelial cells (IC50: 3μg/mL). ISSN : 1041-2905 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=18019081 [article] Biological activities and composition of Salvia muirii L. bol. essential oil [texte imprimé] / Guy P. P. Kamatou, Auteur ; Robyn L. Vanzyl, Auteur ; Sandy F. Van Vuuren, Auteur . - 2013 . - pp. 48-51.
Génie Chimique
Langues : Anglais (eng)
in The journal of essential oil research > Vol. 18 N° Spécial (Juillet 2006) . - pp. 48-51
Mots-clés : Salvia muirii Lamiaceae Biological activities Essential oil composition α-pinene 1,8-cineole Limonene Antimicrobial activity Anti-inflammatory activity Antimalarial activity Antioxidant activity Toxicity Résumé : The essential oil of Salvia muirii L. Bol., a species indigenous to southern Africa was obtained by hydrodistillation (0.5%, v/f.w.) from the aerial parts and analyzed by GC and GC/MS. Thirty-nine components representing 98% of the oil were identified. The oil was dominated by monoterpene hydrocarbons (53%) and oxygen-containing monoterpenes (36%) with 1,8-cineole (23%), α-pinene (22%) and limonene (12%) being the major components. The oil exhibited potent antimalarial (IC50: 6μg/mL) and antibacterial activity especially against Klebsiella pneumoniae and Bacillus cereus with MIC values of 6 and 9mg/mL, respectively. The oil exhibited poor anti-inflammatory and antioxidant activity. The 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide toxicity assay revealed that the essential oil of S. muirii should be used with caution as it displayed some degree of toxicity against the transformed human kidney epithelial cells (IC50: 3μg/mL). ISSN : 1041-2905 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=18019081
in The journal of essential oil research > Vol. 18 N° Spécial (Juillet 2006) . - pp. 72-79
Titre : Chemical composition, leaf trichome types and biological activities of the essential oils of four related salvia species indigenous to Southern Africa Type de document : texte imprimé Auteurs : Guy P. P. Kamatou, Auteur ; Robyn L. Van Zyl, Auteur ; Sandy F. Van Vuuren, Auteur Année de publication : 2013 Article en page(s) : pp. 72-79 Note générale : Génie Chimique Langues : Anglais (eng) Mots-clés : Salvia africana-caerulea Salvia africana-lutea Salvia chamelaeagnea Salvia lanceolata Lamiaceae Trichomes Biological activities Essential oil α-pinene Myrcene 1,8-cineole Spathulenol Caryophyllene-oxide Résumé : The essential oils from fresh aerial parts of four Salvia species indigenous to southern Africa were obtained by hydrodistillation and analyzed by GC and GC/MS. Quantitative rather than qualitative differences in oil composition were observed. Forty-three compounds in each species accounting for 78% (S. africana-caerulea), 78% (S. africana-lutea), 96% (S. chamelaeagnea) and 81% (S. lanceolata) of the total composition were identified. Salvia africana-caerulea and S. lanceolata were dominated by oxygen-containing sesquiterpenes (59% and 48%, respectively). Oxygen-containing monoterpenes dominated in S. chanuslaeagnea (43%), while monoterpene hydrocarbons (36%) were abundant in S. africana-lutea. Scanning electron and light microscopy of the indumentum of the leaves revealed the presence of glandular and non-glandular trichomes. Non-glandular point-shaped trichomes composed of two or three cells are common in all four species and two types of glandular trichomes were noted: peltate trichomes, with up to 16 head cells and a capitate type varying in the number of cells comprising the head and stalk. The oils were evaluated against two Gram-positive and two Gram-negative bacterial strains using the microdilution method and the MIC values ranged from 0.8 to 32 mg/mL. The oils exhibited antiplasmodial (5 < IC50 < 9 pg/mL) and anti-inflammatory (43 < ICc0 < 77 pg/mL) activity as determined by the [3H]-hypoxanthine radiometric and 5-lipoxygenase methods, respectively. Compared to other naturally derived antiplasmodial compounds (e.g. quinine) the oils are more toxic to human kidney epithelium cells (MTT method) with the ICc0 values ranging from 2-7 μg/mL. The oils exhibited poor antioxidant activity against the DPPH' radical at 100 pg/mL. ISSN : 1041-2905 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=18019087 [article] Chemical composition, leaf trichome types and biological activities of the essential oils of four related salvia species indigenous to Southern Africa [texte imprimé] / Guy P. P. Kamatou, Auteur ; Robyn L. Van Zyl, Auteur ; Sandy F. Van Vuuren, Auteur . - 2013 . - pp. 72-79.
Génie Chimique
Langues : Anglais (eng)
in The journal of essential oil research > Vol. 18 N° Spécial (Juillet 2006) . - pp. 72-79
Mots-clés : Salvia africana-caerulea Salvia africana-lutea Salvia chamelaeagnea Salvia lanceolata Lamiaceae Trichomes Biological activities Essential oil α-pinene Myrcene 1,8-cineole Spathulenol Caryophyllene-oxide Résumé : The essential oils from fresh aerial parts of four Salvia species indigenous to southern Africa were obtained by hydrodistillation and analyzed by GC and GC/MS. Quantitative rather than qualitative differences in oil composition were observed. Forty-three compounds in each species accounting for 78% (S. africana-caerulea), 78% (S. africana-lutea), 96% (S. chamelaeagnea) and 81% (S. lanceolata) of the total composition were identified. Salvia africana-caerulea and S. lanceolata were dominated by oxygen-containing sesquiterpenes (59% and 48%, respectively). Oxygen-containing monoterpenes dominated in S. chanuslaeagnea (43%), while monoterpene hydrocarbons (36%) were abundant in S. africana-lutea. Scanning electron and light microscopy of the indumentum of the leaves revealed the presence of glandular and non-glandular trichomes. Non-glandular point-shaped trichomes composed of two or three cells are common in all four species and two types of glandular trichomes were noted: peltate trichomes, with up to 16 head cells and a capitate type varying in the number of cells comprising the head and stalk. The oils were evaluated against two Gram-positive and two Gram-negative bacterial strains using the microdilution method and the MIC values ranged from 0.8 to 32 mg/mL. The oils exhibited antiplasmodial (5 < IC50 < 9 pg/mL) and anti-inflammatory (43 < ICc0 < 77 pg/mL) activity as determined by the [3H]-hypoxanthine radiometric and 5-lipoxygenase methods, respectively. Compared to other naturally derived antiplasmodial compounds (e.g. quinine) the oils are more toxic to human kidney epithelium cells (MTT method) with the ICc0 values ranging from 2-7 μg/mL. The oils exhibited poor antioxidant activity against the DPPH' radical at 100 pg/mL. ISSN : 1041-2905 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=18019087
in The journal of essential oil research > Vol. 18 N° Spécial (Juillet 2006) . - pp. 66-71
Titre : A comparative investigation of the antimicrobial properties of indigenous South African aromatic plants with popular commercially available essential oils Type de document : texte imprimé Auteurs : Sandy F. Van Vuuren, Auteur ; Alvaro M. Viljoen, Auteur Année de publication : 2013 Article en page(s) : pp. 66-71 Note générale : Génie Chimique Langues : Anglais (eng) Mots-clés : Myrothammus flabellifolius Myrothamnaceae Osmitopsis asteriscoides Artemisia afra Asteraceae Lippia javanica Verbenaceae Heteropyxis natalensis Heteropyxidaceae Lavender oil Thyme oil Tea tree oil Rosemary oil Peppermint oil Essential oil composition β-ocimene Linalool 1,8-cineole α-thujone Limonene β-thujone Artemisia ketone Camphor Pinocarvone Trans-pincarveol Antimicrobial activity Résumé : Essential oils have been accepted and recognized as having several therapeutic applications. Popular commercial oils such as lavender, rosemary, tea tree, thyme and peppermint have been used extensively in aromatherapy and as a treatment regimen against bacterial and fungal infections. Extensive studies on indigenous essential oils used in South African traditional healing rites indicate efficacy against a number of pathogens. By means of comparatively determining the MIC of the above-mentioned popular commercial oils against the essential oils of five indigenous plants (Myrothamnus flabellifolius, Osmitopsis asteriscoides, Heteropyxis natalensis, Artemisia afra and Lippiajavanica), efficacy was determined against eight bacterial reference strains and two yeast reference strains. The laboratory conditions and inoculum were standardized to ensure all 10 essential oils (commercial and indigenous) were evaluated under identical conditions. Where MIC data indicated coinciding values between commercial and indigenous oils, the MIC was further refined to narrow the increments. To comparatively demonstrate the time kill efficacy, commercial and indigenous oils were exposed to Staphylococcus aureus, Klebsiella pneunwniae and Candida albicans and the cidal efficacy plotted over time against the logarithm of viable colonies. Results indicate that South African indigenous essential oils compare favorably with commercial oils studied herein. Of all oils studied, Myrothamnus flabellifolius showed the most rapid cidal effect against all three pathogens tested. ISSN : 1041-2905 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=18019086 [article] A comparative investigation of the antimicrobial properties of indigenous South African aromatic plants with popular commercially available essential oils [texte imprimé] / Sandy F. Van Vuuren, Auteur ; Alvaro M. Viljoen, Auteur . - 2013 . - pp. 66-71.
Génie Chimique
Langues : Anglais (eng)
in The journal of essential oil research > Vol. 18 N° Spécial (Juillet 2006) . - pp. 66-71
Mots-clés : Myrothammus flabellifolius Myrothamnaceae Osmitopsis asteriscoides Artemisia afra Asteraceae Lippia javanica Verbenaceae Heteropyxis natalensis Heteropyxidaceae Lavender oil Thyme oil Tea tree oil Rosemary oil Peppermint oil Essential oil composition β-ocimene Linalool 1,8-cineole α-thujone Limonene β-thujone Artemisia ketone Camphor Pinocarvone Trans-pincarveol Antimicrobial activity Résumé : Essential oils have been accepted and recognized as having several therapeutic applications. Popular commercial oils such as lavender, rosemary, tea tree, thyme and peppermint have been used extensively in aromatherapy and as a treatment regimen against bacterial and fungal infections. Extensive studies on indigenous essential oils used in South African traditional healing rites indicate efficacy against a number of pathogens. By means of comparatively determining the MIC of the above-mentioned popular commercial oils against the essential oils of five indigenous plants (Myrothamnus flabellifolius, Osmitopsis asteriscoides, Heteropyxis natalensis, Artemisia afra and Lippiajavanica), efficacy was determined against eight bacterial reference strains and two yeast reference strains. The laboratory conditions and inoculum were standardized to ensure all 10 essential oils (commercial and indigenous) were evaluated under identical conditions. Where MIC data indicated coinciding values between commercial and indigenous oils, the MIC was further refined to narrow the increments. To comparatively demonstrate the time kill efficacy, commercial and indigenous oils were exposed to Staphylococcus aureus, Klebsiella pneunwniae and Candida albicans and the cidal efficacy plotted over time against the logarithm of viable colonies. Results indicate that South African indigenous essential oils compare favorably with commercial oils studied herein. Of all oils studied, Myrothamnus flabellifolius showed the most rapid cidal effect against all three pathogens tested. ISSN : 1041-2905 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=18019086
in The journal of essential oil research > Vol. 18 N° Spécial (Juillet 2006) . - pp. 124-128
Titre : Essential oil composition and in vitro biological activities of seven namibian species of Eriocephalus L. (Asteraceae) Type de document : texte imprimé Auteurs : Alvaro M. Viljoen, Auteur ; Elizabeth W. Njenga, Auteur ; Sandy F. Van Vuuren, Auteur Année de publication : 2013 Article en page(s) : pp. 124-128 Note générale : Génie Chimique Langues : Anglais (eng) Mots-clés : Eriocephalus dinteri Eriocephalus ericoides subsp. ericoides Eriocephalus klinghardtensis Eriocephalus luederitzianus Eriocephalus merxmuelleri Eriocephalus pinnatus Eriocephalus scariosus Asteraceae Namibia Essential oil composition Chemotaxonomy α-pinene β-pinene 1,8-cineole Santolina alcohol Linalool Chrysanthenone Camphor α-longipinene P-caryophyllene Antimicrobial activity Anti-inflammatory activity Résumé : The essential oil composition of seven Namibian Eriocephalus species (E. dinteri, E. ericoides subsp. ericoides, E. klinghardtensis, E. luederitzianus, E. merxmuelleri, E. pinnatus, E. scariosus) were determined by GC and GC/MS. The oils of E. ericoides subsp. ericoides (sample 1), E. merxmuelleri and E. scariosus were found to be rich in 1,8-cineole and camphor. Eriocephalus scariosus oil contained santolina alcohol (14.8%). The highest levels of camphor (38.4%) was found in E. dinteri oil. The major component of E. ericoides subsp. ericoides (sample 2) was linalool (10.4%). A chemical similarity between E. luederitzianus and E. klinghardtensis was observed which both accumulated high levels of α-pinene, β-pinene, p-cymene and γ-terpinene. Eriocephalus luederitzianus oil contained α-longipinene (10.3%) and β-caryophyllene (13.3%). The morphologically anomalous E. pinnatus was very different in oil composition when compared to the other taxa and is characterized by isoamyl 2-methylbutyrate (7.9%) and isoamyl valerate (6.5%). Antimicrobial disc diffusion assays and minimum inhibitory concentrations (MIC) were performed on all seven species. Good antifungal activity was noted for E. ericoides subsp. ericoides. Highest activities were noted for E. merxmuelleri against the Gram-positive test organisms and generally poor activity was noted against the Gram-negative test organisms for all species. The anti-inflammatory activity of the oils were assessed using the 5-lipoxygenase (5-LOX) enzyme and E. dinteri displayed the most promising inhibition (IC50 = 35 μg/ml). ISSN : 1041-2905 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=18019095 [article] Essential oil composition and in vitro biological activities of seven namibian species of Eriocephalus L. (Asteraceae) [texte imprimé] / Alvaro M. Viljoen, Auteur ; Elizabeth W. Njenga, Auteur ; Sandy F. Van Vuuren, Auteur . - 2013 . - pp. 124-128.
Génie Chimique
Langues : Anglais (eng)
in The journal of essential oil research > Vol. 18 N° Spécial (Juillet 2006) . - pp. 124-128
Mots-clés : Eriocephalus dinteri Eriocephalus ericoides subsp. ericoides Eriocephalus klinghardtensis Eriocephalus luederitzianus Eriocephalus merxmuelleri Eriocephalus pinnatus Eriocephalus scariosus Asteraceae Namibia Essential oil composition Chemotaxonomy α-pinene β-pinene 1,8-cineole Santolina alcohol Linalool Chrysanthenone Camphor α-longipinene P-caryophyllene Antimicrobial activity Anti-inflammatory activity Résumé : The essential oil composition of seven Namibian Eriocephalus species (E. dinteri, E. ericoides subsp. ericoides, E. klinghardtensis, E. luederitzianus, E. merxmuelleri, E. pinnatus, E. scariosus) were determined by GC and GC/MS. The oils of E. ericoides subsp. ericoides (sample 1), E. merxmuelleri and E. scariosus were found to be rich in 1,8-cineole and camphor. Eriocephalus scariosus oil contained santolina alcohol (14.8%). The highest levels of camphor (38.4%) was found in E. dinteri oil. The major component of E. ericoides subsp. ericoides (sample 2) was linalool (10.4%). A chemical similarity between E. luederitzianus and E. klinghardtensis was observed which both accumulated high levels of α-pinene, β-pinene, p-cymene and γ-terpinene. Eriocephalus luederitzianus oil contained α-longipinene (10.3%) and β-caryophyllene (13.3%). The morphologically anomalous E. pinnatus was very different in oil composition when compared to the other taxa and is characterized by isoamyl 2-methylbutyrate (7.9%) and isoamyl valerate (6.5%). Antimicrobial disc diffusion assays and minimum inhibitory concentrations (MIC) were performed on all seven species. Good antifungal activity was noted for E. ericoides subsp. ericoides. Highest activities were noted for E. merxmuelleri against the Gram-positive test organisms and generally poor activity was noted against the Gram-negative test organisms for all species. The anti-inflammatory activity of the oils were assessed using the 5-lipoxygenase (5-LOX) enzyme and E. dinteri displayed the most promising inhibition (IC50 = 35 μg/ml). ISSN : 1041-2905 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=18019095
in The journal of essential oil research > Vol. 18 N° Spécial (Juillet 2006) . - pp. 30-36
Titre : A seasonal variation study of the chemical composition and antimicrobial activity of the essential oil of Agathosma ovata (Thunb.) pillans (Rutaceae) Type de document : texte imprimé Auteurs : Alvaro M. Viljoen, Auteur ; Aneesa Moolla, Auteur ; Sandy F. Van Vuuren, Auteur Année de publication : 2013 Article en page(s) : pp. 30-36 Note générale : Génie Chimique Langues : Anglais (eng) Mots-clés : Agathosnw ovata Rutaceae Buchu Essential oil composition Sabinene p-cymene Terpinen-4-ol α-pinene α- thujene Myrcene Limonene Linalool Antimicrobial activity Résumé : A seasonal variation study was performed on the chemical composition of the essential oil of Agathosma ovata (Rutaceae). In addition, this study looked at how variations may impact the antimicrobial activity of A. ovata. The chemical composition of 10 monthly samples, as determined by GC and GC/MS, were found to differ qualitatively and quantitatively and the analysis resulted in the identification of 144 compounds. Sabinene was the major compound in the oil and ranged between 25-44% over the year. The antimicrobial activity was evaluated using the minimum inhibitory concentration (MIC) method on four pathogens, i.e. Staphylococcus aureus, Bacillus cereus, Klebsiella pneumoniae and Candida albicans. Most ofthe samples had MIC values of 8 mg/mL. The activity for Staphylococcus aureus showed the greatest fluctuation (1.5-14 mg/mL) over the seasonal period. ISSN : 1041-2905 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=18019078 [article] A seasonal variation study of the chemical composition and antimicrobial activity of the essential oil of Agathosma ovata (Thunb.) pillans (Rutaceae) [texte imprimé] / Alvaro M. Viljoen, Auteur ; Aneesa Moolla, Auteur ; Sandy F. Van Vuuren, Auteur . - 2013 . - pp. 30-36.
Génie Chimique
Langues : Anglais (eng)
in The journal of essential oil research > Vol. 18 N° Spécial (Juillet 2006) . - pp. 30-36
Mots-clés : Agathosnw ovata Rutaceae Buchu Essential oil composition Sabinene p-cymene Terpinen-4-ol α-pinene α- thujene Myrcene Limonene Linalool Antimicrobial activity Résumé : A seasonal variation study was performed on the chemical composition of the essential oil of Agathosma ovata (Rutaceae). In addition, this study looked at how variations may impact the antimicrobial activity of A. ovata. The chemical composition of 10 monthly samples, as determined by GC and GC/MS, were found to differ qualitatively and quantitatively and the analysis resulted in the identification of 144 compounds. Sabinene was the major compound in the oil and ranged between 25-44% over the year. The antimicrobial activity was evaluated using the minimum inhibitory concentration (MIC) method on four pathogens, i.e. Staphylococcus aureus, Bacillus cereus, Klebsiella pneumoniae and Candida albicans. Most ofthe samples had MIC values of 8 mg/mL. The activity for Staphylococcus aureus showed the greatest fluctuation (1.5-14 mg/mL) over the seasonal period. ISSN : 1041-2905 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=18019078
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