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Biological activities and composition of Salvia muirii L. bol. essential oil / Guy P. P. Kamatou in The journal of essential oil research, Vol. 18 N° Spécial (Juillet 2006) 

Public ISBD [article]  in The journal of essential oil research > Vol. 18 N° Spécial (Juillet 2006) . - pp. 48-51 Titre : Biological activities and composition of Salvia muirii L. bol. essential oil Type de document : texte imprimé Auteurs : Guy P. P. Kamatou, Auteur ; Robyn L. Vanzyl, Auteur ; Sandy F. Van Vuuren, Auteur Année de publication : 2013 Article en page(s) : pp. 48-51 Note générale : Génie Chimique Langues : Anglais (eng) Mots-clés : Salvia  muirii  Lamiaceae  Biological  activities  Essential  oil  composition  α-pinene  1,8-cineole  Limonene  Antimicrobial  activity  Anti-inflammatory  activity  Antimalarial  activity  Antioxidant  activity  Toxicity Résumé : The essential oil of Salvia muirii L. Bol., a species indigenous to southern Africa was obtained by hydrodistillation (0.5%, v/f.w.) from the aerial parts and analyzed by GC and GC/MS. Thirty-nine components representing 98% of the oil were identified. The oil was dominated by monoterpene hydrocarbons (53%) and oxygen-containing monoterpenes (36%) with 1,8-cineole (23%), α-pinene (22%) and limonene (12%) being the major components. The oil exhibited potent antimalarial (IC50: 6μg/mL) and antibacterial activity especially against Klebsiella pneumoniae and Bacillus cereus with MIC values of 6 and 9mg/mL, respectively. The oil exhibited poor anti-inflammatory and antioxidant activity. The 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide toxicity assay revealed that the essential oil of S. muirii should be used with caution as it displayed some degree of toxicity against the transformed human kidney epithelial cells (IC50: 3μg/mL). ISSN : 1041-2905 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=18019081 [article] Biological activities and composition of Salvia muirii L. bol. essential oil [texte imprimé] / Guy P. P. Kamatou, Auteur ; Robyn L. Vanzyl, Auteur ; Sandy F. Van Vuuren, Auteur . - 2013 . - pp. 48-51. Génie Chimique Langues : Anglais (eng) in The journal of essential oil research > Vol. 18 N° Spécial (Juillet 2006) . - pp. 48-51 Mots-clés : Salvia  muirii  Lamiaceae  Biological  activities  Essential  oil  composition  α-pinene  1,8-cineole  Limonene  Antimicrobial  activity  Anti-inflammatory  activity  Antimalarial  activity  Antioxidant  activity  Toxicity Résumé : The essential oil of Salvia muirii L. Bol., a species indigenous to southern Africa was obtained by hydrodistillation (0.5%, v/f.w.) from the aerial parts and analyzed by GC and GC/MS. Thirty-nine components representing 98% of the oil were identified. The oil was dominated by monoterpene hydrocarbons (53%) and oxygen-containing monoterpenes (36%) with 1,8-cineole (23%), α-pinene (22%) and limonene (12%) being the major components. The oil exhibited potent antimalarial (IC50: 6μg/mL) and antibacterial activity especially against Klebsiella pneumoniae and Bacillus cereus with MIC values of 6 and 9mg/mL, respectively. The oil exhibited poor anti-inflammatory and antioxidant activity. The 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide toxicity assay revealed that the essential oil of S. muirii should be used with caution as it displayed some degree of toxicity against the transformed human kidney epithelial cells (IC50: 3μg/mL). ISSN : 1041-2905 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=18019081

Chemical composition, leaf trichome types and biological activities of the essential oils of four related salvia species indigenous to Southern Africa / Guy P. P. Kamatou in The journal of essential oil research, Vol. 18 N° Spécial (Juillet 2006) 

Public ISBD [article]  in The journal of essential oil research > Vol. 18 N° Spécial (Juillet 2006) . - pp. 72-79 Titre : Chemical composition, leaf trichome types and biological activities of the essential oils of four related salvia species indigenous to Southern Africa Type de document : texte imprimé Auteurs : Guy P. P. Kamatou, Auteur ; Robyn L. Van Zyl, Auteur ; Sandy F. Van Vuuren, Auteur Année de publication : 2013 Article en page(s) : pp. 72-79 Note générale : Génie Chimique Langues : Anglais (eng) Mots-clés : Salvia  africana-caerulea  Salvia  africana-lutea  Salvia  chamelaeagnea  Salvia  lanceolata  Lamiaceae  Trichomes  Biological  activities  Essential  oil  α-pinene  Myrcene  1,8-cineole  Spathulenol  Caryophyllene-oxide Résumé : The essential oils from fresh aerial parts of four Salvia species indigenous to southern Africa were obtained by hydrodistillation and analyzed by GC and GC/MS. Quantitative rather than qualitative differences in oil composition were observed. Forty-three compounds in each species accounting for 78% (S. africana-caerulea), 78% (S. africana-lutea), 96% (S. chamelaeagnea) and 81% (S. lanceolata) of the total composition were identified. Salvia africana-caerulea and S. lanceolata were dominated by oxygen-containing sesquiterpenes (59% and 48%, respectively). Oxygen-containing monoterpenes dominated in S. chanuslaeagnea (43%), while monoterpene hydrocarbons (36%) were abundant in S. africana-lutea. Scanning electron and light microscopy of the indumentum of the leaves revealed the presence of glandular and non-glandular trichomes. Non-glandular point-shaped trichomes composed of two or three cells are common in all four species and two types of glandular trichomes were noted: peltate trichomes, with up to 16 head cells and a capitate type varying in the number of cells comprising the head and stalk. The oils were evaluated against two Gram-positive and two Gram-negative bacterial strains using the microdilution method and the MIC values ranged from 0.8 to 32 mg/mL. The oils exhibited antiplasmodial (5 < IC50 < 9 pg/mL) and anti-inflammatory (43 < ICc0 < 77 pg/mL) activity as determined by the [3H]-hypoxanthine radiometric and 5-lipoxygenase methods, respectively. Compared to other naturally derived antiplasmodial compounds (e.g. quinine) the oils are more toxic to human kidney epithelium cells (MTT method) with the ICc0 values ranging from 2-7 μg/mL. The oils exhibited poor antioxidant activity against the DPPH' radical at 100 pg/mL. ISSN : 1041-2905 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=18019087 [article] Chemical composition, leaf trichome types and biological activities of the essential oils of four related salvia species indigenous to Southern Africa [texte imprimé] / Guy P. P. Kamatou, Auteur ; Robyn L. Van Zyl, Auteur ; Sandy F. Van Vuuren, Auteur . - 2013 . - pp. 72-79. Génie Chimique Langues : Anglais (eng) in The journal of essential oil research > Vol. 18 N° Spécial (Juillet 2006) . - pp. 72-79 Mots-clés : Salvia  africana-caerulea  Salvia  africana-lutea  Salvia  chamelaeagnea  Salvia  lanceolata  Lamiaceae  Trichomes  Biological  activities  Essential  oil  α-pinene  Myrcene  1,8-cineole  Spathulenol  Caryophyllene-oxide Résumé : The essential oils from fresh aerial parts of four Salvia species indigenous to southern Africa were obtained by hydrodistillation and analyzed by GC and GC/MS. Quantitative rather than qualitative differences in oil composition were observed. Forty-three compounds in each species accounting for 78% (S. africana-caerulea), 78% (S. africana-lutea), 96% (S. chamelaeagnea) and 81% (S. lanceolata) of the total composition were identified. Salvia africana-caerulea and S. lanceolata were dominated by oxygen-containing sesquiterpenes (59% and 48%, respectively). Oxygen-containing monoterpenes dominated in S. chanuslaeagnea (43%), while monoterpene hydrocarbons (36%) were abundant in S. africana-lutea. Scanning electron and light microscopy of the indumentum of the leaves revealed the presence of glandular and non-glandular trichomes. Non-glandular point-shaped trichomes composed of two or three cells are common in all four species and two types of glandular trichomes were noted: peltate trichomes, with up to 16 head cells and a capitate type varying in the number of cells comprising the head and stalk. The oils were evaluated against two Gram-positive and two Gram-negative bacterial strains using the microdilution method and the MIC values ranged from 0.8 to 32 mg/mL. The oils exhibited antiplasmodial (5 < IC50 < 9 pg/mL) and anti-inflammatory (43 < ICc0 < 77 pg/mL) activity as determined by the [3H]-hypoxanthine radiometric and 5-lipoxygenase methods, respectively. Compared to other naturally derived antiplasmodial compounds (e.g. quinine) the oils are more toxic to human kidney epithelium cells (MTT method) with the ICc0 values ranging from 2-7 μg/mL. The oils exhibited poor antioxidant activity against the DPPH' radical at 100 pg/mL. ISSN : 1041-2905 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=18019087

The essential oil composition and chemotaxonomy of Salvia stenophylla and its allies S. repens and S. runcinata / Alvaro M. Viljoen in The journal of essential oil research, Vol. 18 N° Spécial (Juillet 2006) 

Public ISBD [article]  in The journal of essential oil research > Vol. 18 N° Spécial (Juillet 2006) . - pp. 37-45 Titre : The essential oil composition and chemotaxonomy of Salvia stenophylla and its allies S. repens and S. runcinata Type de document : texte imprimé Auteurs : Alvaro M. Viljoen, Auteur ; Angela Gono-Bwalya, Auteur ; Guy P. P. Kamatou, Auteur Année de publication : 2013 Article en page(s) : pp. 37-45 Note générale : Génie Chimique Langues : Anglais (eng) Mots-clés : Salvia  stenophylla  Salvia  repens  Salvia  runcinata  Lamiaceae  Essential  oil  composition  Chemotypes  α-pinene  8-3-carene  Limonene  1,8-cineole  P-phellandrene  (Z)-β-ocimene  γ-terpinene  β-caryophyllene  β-bisabolene  (E)-  nerolidol  Guaiol  α-bisabolol  δ-eudesmol  β-eudesmol  Cis-lanceol  Manool Résumé : salvia stenophylla Burch. ex Benth. (Lamiaceae) is a perennial aromatic herb, which is widespread in the high altitude areas of the central and eastern parts of South Africa. It is closely related to Salvia runcinata L. f. and Salvia repens Burch, ex Benth. with which it forms a species complex. Taxonomically, distinction between the three taxa is problematic. Salvia stenophylla is economically important as a source of α-bisabolol used in aromatherapy and active cosmetic formulations. The fresh aerial parts of the three taxa obtained from 25 natural populations were hydrodistilled to isolate the essential oil and analytical assessment of the oil was carried out using gas chromatography coupled to mass spectroscopy (GC/MS). The GC/M results showed variation in the qualitative and quantitative chemical composition within and between populations of the same and different taxa. The dominant compounds in the S. stenophylla oils include: α-bisabolol (46.5%), limonene (38.1%), δ-3-carene (24.9%), γ-terpinene (20.3%), p-cymene (18.4%) and (E)-nerolidol (53.6%). Salvia repens oils accumulated major compounds like (E)-nerolidol (25.2%), ledol (25.4%), camphor (12.7%), β-caryophyllene( (13.6%) and p-phellandrene (22.2%). Salvia runcinata oils had (E)-nerolidol (72%), α-bisabolol (41.1%), limonene (24.1%), α-pinene (45%) and β-pinene (15%) and 26% of guaiol in high percentages. Seven chemotypes were identified and they were used to investigate the chemotaxomic relationships in the species complex. The results suggested that S. stenophylla and S. repens are the closest allies within the complex. ISSN : 1041-2905 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=18019079 [article] The essential oil composition and chemotaxonomy of Salvia stenophylla and its allies S. repens and S. runcinata [texte imprimé] / Alvaro M. Viljoen, Auteur ; Angela Gono-Bwalya, Auteur ; Guy P. P. Kamatou, Auteur . - 2013 . - pp. 37-45. Génie Chimique Langues : Anglais (eng) in The journal of essential oil research > Vol. 18 N° Spécial (Juillet 2006) . - pp. 37-45 Mots-clés : Salvia  stenophylla  Salvia  repens  Salvia  runcinata  Lamiaceae  Essential  oil  composition  Chemotypes  α-pinene  8-3-carene  Limonene  1,8-cineole  P-phellandrene  (Z)-β-ocimene  γ-terpinene  β-caryophyllene  β-bisabolene  (E)-  nerolidol  Guaiol  α-bisabolol  δ-eudesmol  β-eudesmol  Cis-lanceol  Manool Résumé : salvia stenophylla Burch. ex Benth. (Lamiaceae) is a perennial aromatic herb, which is widespread in the high altitude areas of the central and eastern parts of South Africa. It is closely related to Salvia runcinata L. f. and Salvia repens Burch, ex Benth. with which it forms a species complex. Taxonomically, distinction between the three taxa is problematic. Salvia stenophylla is economically important as a source of α-bisabolol used in aromatherapy and active cosmetic formulations. The fresh aerial parts of the three taxa obtained from 25 natural populations were hydrodistilled to isolate the essential oil and analytical assessment of the oil was carried out using gas chromatography coupled to mass spectroscopy (GC/MS). The GC/M results showed variation in the qualitative and quantitative chemical composition within and between populations of the same and different taxa. The dominant compounds in the S. stenophylla oils include: α-bisabolol (46.5%), limonene (38.1%), δ-3-carene (24.9%), γ-terpinene (20.3%), p-cymene (18.4%) and (E)-nerolidol (53.6%). Salvia repens oils accumulated major compounds like (E)-nerolidol (25.2%), ledol (25.4%), camphor (12.7%), β-caryophyllene( (13.6%) and p-phellandrene (22.2%). Salvia runcinata oils had (E)-nerolidol (72%), α-bisabolol (41.1%), limonene (24.1%), α-pinene (45%) and β-pinene (15%) and 26% of guaiol in high percentages. Seven chemotypes were identified and they were used to investigate the chemotaxomic relationships in the species complex. The results suggested that S. stenophylla and S. repens are the closest allies within the complex. ISSN : 1041-2905 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=18019079