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In vitro 5-lipoxygenase activity of three indigenous south african aromatic plants used in traditional healing and the stereospecific activity of limonene in the 5-lipoxygenase assay / Yakov Frum in The journal of essential oil research, Vol. 18 N° Spécial (Juillet 2006) 

Public ISBD [article]  in The journal of essential oil research > Vol. 18 N° Spécial (Juillet 2006) . - pp. 85-88 Titre : In vitro 5-lipoxygenase activity of three indigenous south african aromatic plants used in traditional healing and the stereospecific activity of limonene in the 5-lipoxygenase assay Type de document : texte imprimé Auteurs : Yakov Frum, Auteur ; Alvaro M. Viljoen, Auteur Année de publication : 2013 Article en page(s) : pp. 85-88 Note générale : Génie Chimique Langues : Anglais (eng) Mots-clés : Helichrysum  odoratissimum  Asteraceae  Heteropyxis  natalensis  Heteropyxidaceae  Lippiajawanica  Verbenaceae  Essential  oil  composition  Limonene  Linalool  1,8-cineole  (Z)-β-ocimene  5-lipoxygenase  Anti-inflammatory Résumé : An investigation was .undertaken to determine the 5-lipoxygenase inhibitory activity of aromatic plants traditionally used to treat dermatological pathologies. Guided by ethnobotanical literature and availability from natural sources, the essential oils of Helichrysum odoratissimum (L.) Less., Heteropyxis natalensis Harv. and Lippia javanica (Burm. f.) Spreng. were collected. The hydrodistilled essential oils displayed promising 5-lipoxygenase inhibitory activity with IC50 values between 35 and 75 ppm. The oil compositions were determined by GC and GC/MS. Major compounds possibly contributing to the anti-inflammatory activity include β-caryophyllene, 1,8-cineole and limonene. Enantiomers and racemic mixtures of limonene displayed significantly different 5-lipoxygenase inhibitory activity suggesting stereoselectivity of the enzyme-catalyzed reaction. Furthermore, the monoterpene 1,8-cineole appeared to cause partial potentiation of the anti-inflammatory activity displayed by limonene. ISSN : 1041-2905 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=18019089 [article] In vitro 5-lipoxygenase activity of three indigenous south african aromatic plants used in traditional healing and the stereospecific activity of limonene in the 5-lipoxygenase assay [texte imprimé] / Yakov Frum, Auteur ; Alvaro M. Viljoen, Auteur . - 2013 . - pp. 85-88. Génie Chimique Langues : Anglais (eng) in The journal of essential oil research > Vol. 18 N° Spécial (Juillet 2006) . - pp. 85-88 Mots-clés : Helichrysum  odoratissimum  Asteraceae  Heteropyxis  natalensis  Heteropyxidaceae  Lippiajawanica  Verbenaceae  Essential  oil  composition  Limonene  Linalool  1,8-cineole  (Z)-β-ocimene  5-lipoxygenase  Anti-inflammatory Résumé : An investigation was .undertaken to determine the 5-lipoxygenase inhibitory activity of aromatic plants traditionally used to treat dermatological pathologies. Guided by ethnobotanical literature and availability from natural sources, the essential oils of Helichrysum odoratissimum (L.) Less., Heteropyxis natalensis Harv. and Lippia javanica (Burm. f.) Spreng. were collected. The hydrodistilled essential oils displayed promising 5-lipoxygenase inhibitory activity with IC50 values between 35 and 75 ppm. The oil compositions were determined by GC and GC/MS. Major compounds possibly contributing to the anti-inflammatory activity include β-caryophyllene, 1,8-cineole and limonene. Enantiomers and racemic mixtures of limonene displayed significantly different 5-lipoxygenase inhibitory activity suggesting stereoselectivity of the enzyme-catalyzed reaction. Furthermore, the monoterpene 1,8-cineole appeared to cause partial potentiation of the anti-inflammatory activity displayed by limonene. ISSN : 1041-2905 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=18019089