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Micronization of p - aminosalicylic acid particles using high-gravity technique / Yu-Shao Chen in Industrial & engineering chemistry research, Vol. 49 N° 18 (Septembre 2010) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 49 N° 18 (Septembre 2010) . - pp. 8832–8840 Titre : Micronization of p - aminosalicylic acid particles using high-gravity technique Type de document : texte imprimé Auteurs : Yu-Shao Chen, Auteur ; Yao-Hsuan Wang, Auteur ; Hwai-Shen Liu, Auteur Année de publication : 2010 Article en page(s) : pp. 8832–8840 Note générale : Industrial chemistry Langues : Anglais (eng) Mots-clés : Particles  High  Gravity  Technique Résumé : An antisolvent precipitation process was adopted in this study to prepare micrometer-sized p-aminosalicylic acid (PAS) particles using the high-gravity technique. The effects of operating variables on the particle size were investigated. With an increase in the dispersant concentration and disk diameter or a decrease in the drug (PAS) concentration, the particle size of PAS was reduced. In addition, a circular-tube distributor was more effective than a straight-tube distributor for micronization. On the other hand, the effect of the liquid flow rate in the range between 0.25 and 1 L/min was less significant. The high-pressure homogenization following the high-gravity precipitation would effectively reduce the agglomeration of the particles in the suspension to produce drug particles with a mean size of 1 μm. The enhancement of the dissolution rate was significant for the micronized drug particles. The results indicate that the high-gravity process is a promising approach for micronizing drug particles. ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie1007932 [article] Micronization of p - aminosalicylic acid particles using high-gravity technique [texte imprimé] / Yu-Shao Chen, Auteur ; Yao-Hsuan Wang, Auteur ; Hwai-Shen Liu, Auteur . - 2010 . - pp. 8832–8840. Industrial chemistry Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 49 N° 18 (Septembre 2010) . - pp. 8832–8840 Mots-clés : Particles  High  Gravity  Technique Résumé : An antisolvent precipitation process was adopted in this study to prepare micrometer-sized p-aminosalicylic acid (PAS) particles using the high-gravity technique. The effects of operating variables on the particle size were investigated. With an increase in the dispersant concentration and disk diameter or a decrease in the drug (PAS) concentration, the particle size of PAS was reduced. In addition, a circular-tube distributor was more effective than a straight-tube distributor for micronization. On the other hand, the effect of the liquid flow rate in the range between 0.25 and 1 L/min was less significant. The high-pressure homogenization following the high-gravity precipitation would effectively reduce the agglomeration of the particles in the suspension to produce drug particles with a mean size of 1 μm. The enhancement of the dissolution rate was significant for the micronized drug particles. The results indicate that the high-gravity process is a promising approach for micronizing drug particles. ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie1007932

Preparation of silver nanoparticles using a spinning disk reactor in a continuous mode / Clifford Y. Tai in Industrial & engineering chemistry research, Vol. 48 N° 22 (Novembre 2009) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 48 N° 22 (Novembre 2009) . - pp. 10104–10109 Titre : Preparation of silver nanoparticles using a spinning disk reactor in a continuous mode Type de document : texte imprimé Auteurs : Clifford Y. Tai, Auteur ; Yao-Hsuan Wang, Auteur ; Chia-Te Tai, Auteur Année de publication : 2010 Article en page(s) : pp. 10104–10109 Note générale : Chemical engineering Langues : Anglais (eng) Mots-clés : Spinning  disk  reactor  Silver  nanoparticles  Hydroxypropylmethyl  cellulose  poly(vinylpyrrolidone)  cellulose Résumé : A spinning disk reactor (SDR) operated in a continuous mode was adopted for producing silver nanoparticles, aiming at an increase in the production rate. Two protecting agents, i.e., poly(vinylpyrrolidone) (PVP) and hydroxypropylmethyl cellulose (HPMC), were tested, which have been proven to be effective in our previous work of recycle operation. Using PVP as protecting agent, the effects of the operating variables, including the rotation speed, the feeding rate, the dosage of protecting agent, and reactant concentration, on the particle size and yield of the silver product were investigated. The experiment was further conducted using HPMC as protecting agent to compare the experimental results between the two protecting agents. The use of PVP gave smaller silver nanoparticles; however, a higher yield was obtained by using HPMC. Although the yield of continuous operation was lower than that of recycle operation, the production rate was much higher for either protecting agent, providing a great potential for commercialization. En ligne : http://pubs.acs.org/doi/abs/10.1021/ie9005645 [article] Preparation of silver nanoparticles using a spinning disk reactor in a continuous mode [texte imprimé] / Clifford Y. Tai, Auteur ; Yao-Hsuan Wang, Auteur ; Chia-Te Tai, Auteur . - 2010 . - pp. 10104–10109. Chemical engineering Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 48 N° 22 (Novembre 2009) . - pp. 10104–10109 Mots-clés : Spinning  disk  reactor  Silver  nanoparticles  Hydroxypropylmethyl  cellulose  poly(vinylpyrrolidone)  cellulose Résumé : A spinning disk reactor (SDR) operated in a continuous mode was adopted for producing silver nanoparticles, aiming at an increase in the production rate. Two protecting agents, i.e., poly(vinylpyrrolidone) (PVP) and hydroxypropylmethyl cellulose (HPMC), were tested, which have been proven to be effective in our previous work of recycle operation. Using PVP as protecting agent, the effects of the operating variables, including the rotation speed, the feeding rate, the dosage of protecting agent, and reactant concentration, on the particle size and yield of the silver product were investigated. The experiment was further conducted using HPMC as protecting agent to compare the experimental results between the two protecting agents. The use of PVP gave smaller silver nanoparticles; however, a higher yield was obtained by using HPMC. Although the yield of continuous operation was lower than that of recycle operation, the production rate was much higher for either protecting agent, providing a great potential for commercialization. En ligne : http://pubs.acs.org/doi/abs/10.1021/ie9005645