Multiple microcapillary reactor for organic synthesis / Christian H. Hornung in Industrial & engineering chemistry research, Vol. 49 N° 10 (Mai 2010)  

Public ISBD [article]  inIndustrial & engineering chemistry research > Vol. 49 N° 10 (Mai 2010) . - pp. 4576–4582 Titre : Multiple microcapillary reactor for organic synthesis Type de document : texte imprimé Auteurs : Christian H. Hornung, Auteur ; Bart Hallmark, Auteur ; Marcus Baumann, Auteur Année de publication : 2010 Article en page(s) : pp. 4576–4582 Note générale : Industrial chemistry Langues : Anglais (eng) Mots-clés : Microcapillary reactor Résumé : This paper presents process characteristics and proof of concept reactions for a newly developed microreactor system, termed the Cambridge Disc Microreactor (CDM), using plastic microcapillary flow discs (MFDs). These flat reactor discs were constructed from a flexible, temperature resilient, solvent resistant fluoropolymer microcapillary film (MCF) comprising 10 parallel capillary channels with mean hydraulic diameters typically between 150 and 400 μm. The MFDs were heated inside the microreactor via conductive heat transfer from two heated surfaces, which were in contact with the flat outer surfaces of the disc. This allowed continuous flow processing of liquid phase reactions through the reactor at elevated temperatures and pressures at a precisely controlled residence time. The process characteristics of the reactor system were established experimentally by investigating the hydraulic response and the temperature profile or modeled analytically such that the residence time characteristics inside the device could be predicted. A series of organic chemical reactions, namely electrophilic fluorination and the formation of various mono- and bicyclic heteroaromatic compounds, were conducted in the system at temperatures between 110 and 120 °C. ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie901674h [article] Multiple microcapillary reactor for organic synthesis [texte imprimé] / Christian H. Hornung, Auteur ; Bart Hallmark, Auteur ; Marcus Baumann, Auteur . - 2010 . - pp. 4576–4582. Industrial chemistry Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 49 N° 10 (Mai 2010) . - pp. 4576–4582 Mots-clés : Microcapillary reactor Résumé : This paper presents process characteristics and proof of concept reactions for a newly developed microreactor system, termed the Cambridge Disc Microreactor (CDM), using plastic microcapillary flow discs (MFDs). These flat reactor discs were constructed from a flexible, temperature resilient, solvent resistant fluoropolymer microcapillary film (MCF) comprising 10 parallel capillary channels with mean hydraulic diameters typically between 150 and 400 μm. The MFDs were heated inside the microreactor via conductive heat transfer from two heated surfaces, which were in contact with the flat outer surfaces of the disc. This allowed continuous flow processing of liquid phase reactions through the reactor at elevated temperatures and pressures at a precisely controlled residence time. The process characteristics of the reactor system were established experimentally by investigating the hydraulic response and the temperature profile or modeled analytically such that the residence time characteristics inside the device could be predicted. A series of organic chemical reactions, namely electrophilic fluorination and the formation of various mono- and bicyclic heteroaromatic compounds, were conducted in the system at temperatures between 110 and 120 °C. ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie901674h

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