Alternative method with amperometric detection for ranitidine determination / Valeria Pfaffen in Industrial & engineering chemistry research, Vol. 49 N° 9 (Mai 2010)  

Public ISBD [article]  inIndustrial & engineering chemistry research > Vol. 49 N° 9 (Mai 2010) . - pp. 4026-4030 Titre : Alternative method with amperometric detection for ranitidine determination Type de document : texte imprimé Auteurs : Valeria Pfaffen, Auteur ; Patricia Inés Ortiz, Auteur Année de publication : 2010 Article en page(s) : pp. 4026-4030 Note générale : Industrial chemistry Langues : Anglais (eng) Mots-clés : Amperometric Detection Ranitidine Résumé : An alternative, simple, and reliable FIA amperometric method for ranitidine quantification was developed. A working glassy carbon electrode and a Ag|AgCl|NaCl (3 M) reference electrode were used. The determination is based on the electrochemical oxidation of ranitidine at 1.2 V in phosphate buffer solution (pH 7.2). The determination of ranitidine in the range of 1 × 10−6 to 2 × 10−5 M was possible with a sampling frequency of 120 h−1. The method was validated and satisfactorily applied to the determination of ranitidine in pharmaceutical formulations with a low limit of detection (6 × 10−7 M) and a quantitative recovery with no interferences from excipients. The results compare favorably with those obtained by the liquid chromatographic method of the U.S. Pharmacopoeia. ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie901895a [article] Alternative method with amperometric detection for ranitidine determination [texte imprimé] / Valeria Pfaffen, Auteur ; Patricia Inés Ortiz, Auteur . - 2010 . - pp. 4026-4030. Industrial chemistry Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 49 N° 9 (Mai 2010) . - pp. 4026-4030 Mots-clés : Amperometric Detection Ranitidine Résumé : An alternative, simple, and reliable FIA amperometric method for ranitidine quantification was developed. A working glassy carbon electrode and a Ag|AgCl|NaCl (3 M) reference electrode were used. The determination is based on the electrochemical oxidation of ranitidine at 1.2 V in phosphate buffer solution (pH 7.2). The determination of ranitidine in the range of 1 × 10−6 to 2 × 10−5 M was possible with a sampling frequency of 120 h−1. The method was validated and satisfactorily applied to the determination of ranitidine in pharmaceutical formulations with a low limit of detection (6 × 10−7 M) and a quantitative recovery with no interferences from excipients. The results compare favorably with those obtained by the liquid chromatographic method of the U.S. Pharmacopoeia. ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie901895a

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