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Sedative effect of vapor inhalation of essential oil from heracleum afghanicum kitamura seeds / Abdul Ghani Karimi in The journal of essential oil research, Vol. 24 N° 6 (Décembre 2012) 

Public ISBD [article]  in The journal of essential oil research > Vol. 24 N° 6 (Décembre 2012) . - pp. 571-577 Titre : Sedative effect of vapor inhalation of essential oil from heracleum afghanicum kitamura seeds Type de document : texte imprimé Auteurs : Abdul Ghani Karimi, Auteur ; Michiho Ito, Auteur Année de publication : 2014 Article en page(s) : pp. 571-577 Note générale : Génie Chimique Langues : Anglais (eng) Mots-clés : Heracleum  afghanicum  Apiaceae  Essential  oil  composition  Vapor  inhalation  Sedative  effect  Aliphatic  esters  Hexyl  butyrate  Octyl  acetate Résumé : Heracleum afghanicum (Apiaceae) is a perennial plant indigenous to Afghanistan. Phytochemical and pharmacological analyses of H. afghanicum seeds essential oil were carried out to investigate its possible sedative effects on mice spontaneous locomotor activity. The essential oil was analyzed by gas chromatography (GC) and GC/mass spectrometry (GC/MS), and thirty-three constituents were identified. Hexyl butyrate (34.3%) and octyl acetate (21.1%) were found as its principal constituents. The sedative effect of H. afghanicum essential oil was confirmed using an open field test with ddY mice. The essential oil significantly decreased the locomotor activity of mice, suggesting its sedative effect. Hexyl butyrate and octyl acetate were found to be responsible for the sedative activity of H. afghanicum seeds essential oil. ISSN : 1041-2905 En ligne : http://www.tandfonline.com/doi/full/10.1080/10412905.2012.728085 [article] Sedative effect of vapor inhalation of essential oil from heracleum afghanicum kitamura seeds [texte imprimé] / Abdul Ghani Karimi, Auteur ; Michiho Ito, Auteur . - 2014 . - pp. 571-577. Génie Chimique Langues : Anglais (eng) in The journal of essential oil research > Vol. 24 N° 6 (Décembre 2012) . - pp. 571-577 Mots-clés : Heracleum  afghanicum  Apiaceae  Essential  oil  composition  Vapor  inhalation  Sedative  effect  Aliphatic  esters  Hexyl  butyrate  Octyl  acetate Résumé : Heracleum afghanicum (Apiaceae) is a perennial plant indigenous to Afghanistan. Phytochemical and pharmacological analyses of H. afghanicum seeds essential oil were carried out to investigate its possible sedative effects on mice spontaneous locomotor activity. The essential oil was analyzed by gas chromatography (GC) and GC/mass spectrometry (GC/MS), and thirty-three constituents were identified. Hexyl butyrate (34.3%) and octyl acetate (21.1%) were found as its principal constituents. The sedative effect of H. afghanicum essential oil was confirmed using an open field test with ddY mice. The essential oil significantly decreased the locomotor activity of mice, suggesting its sedative effect. Hexyl butyrate and octyl acetate were found to be responsible for the sedative activity of H. afghanicum seeds essential oil. ISSN : 1041-2905 En ligne : http://www.tandfonline.com/doi/full/10.1080/10412905.2012.728085