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Phase-transfer catalysis in segmented flow in a microchannel / Jovan Jovanović in Industrial & engineering chemistry research, Vol. 49 N° 6 (Mars 2010) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 49 N° 6 (Mars 2010) . - pp. 2681–2687 Titre : Phase-transfer catalysis in segmented flow in a microchannel : fluidic control of selectivity and productivity Type de document : texte imprimé Auteurs : Jovan Jovanović, Auteur ; Evgeny V. Rebrov, Auteur ; T. A. (Xander) Nijhuis, Auteur Année de publication : 2010 Article en page(s) : pp. 2681–2687 Note générale : Industrial Chemistry Langues : Anglais (eng) Mots-clés : Catalysis  in  Segmented  Flow  Microchannel  Fluidic  Selectivity  Productivity Résumé : Precise control over the interfacial area of aqueous and organic slugs in segmented flow in a microchannel reactor provides an attractive means to optimize the yield and productivity of a phase-transfer-catalyzed reaction. Herein, we report the selective alkylation of phenylacetonitrile to the monoalkylated product in a microchannel of 250-μm internal diameter operated in a continuous and solvent-free manner in the slug-flow regime. The conversion of phenylacetonitrile increased from 40% to 99% as a result of a 97% larger slug surface-to-volume ratio when the volumetric aqueous-to-organic phase flow ratio was raised from 1.0 to 6.1 at the same residence time. The larger surface-to-volume ratio significantly promoted catalyst phase transfer but decreased selectivity because of the simultaneous increase of the rate of the consecutive reaction to the dialkylated product. There exists an optimum flow ratio with a maximum productivity. Conversion and selectivity in the microchannel reactor were both found to be significantly larger than in a stirred reactor. ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie9017918 [article] Phase-transfer catalysis in segmented flow in a microchannel : fluidic control of selectivity and productivity [texte imprimé] / Jovan Jovanović, Auteur ; Evgeny V. Rebrov, Auteur ; T. A. (Xander) Nijhuis, Auteur . - 2010 . - pp. 2681–2687. Industrial Chemistry Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 49 N° 6 (Mars 2010) . - pp. 2681–2687 Mots-clés : Catalysis  in  Segmented  Flow  Microchannel  Fluidic  Selectivity  Productivity Résumé : Precise control over the interfacial area of aqueous and organic slugs in segmented flow in a microchannel reactor provides an attractive means to optimize the yield and productivity of a phase-transfer-catalyzed reaction. Herein, we report the selective alkylation of phenylacetonitrile to the monoalkylated product in a microchannel of 250-μm internal diameter operated in a continuous and solvent-free manner in the slug-flow regime. The conversion of phenylacetonitrile increased from 40% to 99% as a result of a 97% larger slug surface-to-volume ratio when the volumetric aqueous-to-organic phase flow ratio was raised from 1.0 to 6.1 at the same residence time. The larger surface-to-volume ratio significantly promoted catalyst phase transfer but decreased selectivity because of the simultaneous increase of the rate of the consecutive reaction to the dialkylated product. There exists an optimum flow ratio with a maximum productivity. Conversion and selectivity in the microchannel reactor were both found to be significantly larger than in a stirred reactor. ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie9017918