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Investigation on the spherical crystallization process of cefotaxime sodium / Haitao Zhang in Industrial & engineering chemistry research, Vol. 49 N° 3 (Fevrier 2010)

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 49 N° 3 (Fevrier 2010) . - pp. 1402–1411 Titre : Investigation on the spherical crystallization process of cefotaxime sodium Type de document : texte imprimé Auteurs : Haitao Zhang, Auteur ; Ying Chen, Auteur ; Jingkang Wang, Auteur Année de publication : 2010 Article en page(s) : pp. 1402–1411 Note générale : Industrial chemistry Langues : Anglais (eng) Mots-clés : Investigation  on  the  Spherical  Crystallization  Process  of  Cefotaxime  Sodium Résumé : In order to obtain satisfied spherical agglomerated product and overcome the incomplete removal of the impurity during the traditional spherical agglomerated process, a new strategy incorporating the spherical agglomeration technique and the drowning-out crystallization process, by which the impurities can be efficiently removed, was performed. A triangular phase diagram showing the phase equilibrium of ternary solvent mixtures used in the process of spherical crystallization was constructed and the real-time spherical crystallization process was investigated by means of particle vision measurement and microscopy. The operation conditions, including the chloroform content, temperature of the system, and agitation speed, were also investigated in order to optimize the spherical crystallization process. The results of HPLC and GC indicated that the purity and residual solvents of the experimental agglomerated product can meet the requirements for use. Simultaneously, their bulk density, flowability, and compressibility are far better than the dispersed crystals. The agglomerated particle size was easily controlled by adjusting the chloroform content, temperature of the system, and agitation during spherical crystallization. Especially, the chloroform content is much more important than temperature and agitation in determining agglomerated particle size. ISSN : 0888-5885 [article] Investigation on the spherical crystallization process of cefotaxime sodium [texte imprimé] / Haitao Zhang, Auteur ; Ying Chen, Auteur ; Jingkang Wang, Auteur . - 2010 . - pp. 1402–1411. Industrial chemistry Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 49 N° 3 (Fevrier 2010) . - pp. 1402–1411 Mots-clés : Investigation  on  the  Spherical  Crystallization  Process  of  Cefotaxime  Sodium Résumé : In order to obtain satisfied spherical agglomerated product and overcome the incomplete removal of the impurity during the traditional spherical agglomerated process, a new strategy incorporating the spherical agglomeration technique and the drowning-out crystallization process, by which the impurities can be efficiently removed, was performed. A triangular phase diagram showing the phase equilibrium of ternary solvent mixtures used in the process of spherical crystallization was constructed and the real-time spherical crystallization process was investigated by means of particle vision measurement and microscopy. The operation conditions, including the chloroform content, temperature of the system, and agitation speed, were also investigated in order to optimize the spherical crystallization process. The results of HPLC and GC indicated that the purity and residual solvents of the experimental agglomerated product can meet the requirements for use. Simultaneously, their bulk density, flowability, and compressibility are far better than the dispersed crystals. The agglomerated particle size was easily controlled by adjusting the chloroform content, temperature of the system, and agitation during spherical crystallization. Especially, the chloroform content is much more important than temperature and agitation in determining agglomerated particle size. ISSN : 0888-5885