Optimal startup/shutdown operating policies with a recombinant strain continuously stirred bioreactor / Letizia Luperini-Enciso in Industrial & engineering chemistry research, Vol. 49 N° 1 (Janvier 2010)  

Public ISBD [article]  inIndustrial & engineering chemistry research > Vol. 49 N° 1 (Janvier 2010) . - pp. 308–316 Titre : Optimal startup/shutdown operating policies with a recombinant strain continuously stirred bioreactor Type de document : texte imprimé Auteurs : Letizia Luperini-Enciso, Auteur ; Holda Purón-Zepeda, Auteur ; Lorena Pedraza-Segura, Auteur Année de publication : 2010 Article en page(s) : pp. 308–316 Note générale : Industrial chemistry Langues : Anglais (eng) Mots-clés : Optimal--Startup--Shutdown--Operating--Policies--Recombinant--Strain--Continuously--Stirred--Bioreactor Résumé : In this work dynamic optimal startup and shutdown policies were computed and validated in an experimental lab-scale continuous bioreactor. Using the theoretical optimal profile, a reduction in the startup time was achieved when compared to simple steplike changes in the manipulated variables. Therefore, the use of optimal startup policies led to raw material savings. To test the optimal startup policies, two operating points were selected. Experiments were run at these conditions to fit kinetic rate constants leading to a reliable model representation of the addressed biosystem. The practical implementation of theoretical optimization results is not a trivial task, and this is a major contribution of the present work. This is true especially for the optimal dynamic shutdown results that are not, up to our best knowledge, reported in the open literature. ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie901138p [article] Optimal startup/shutdown operating policies with a recombinant strain continuously stirred bioreactor [texte imprimé] / Letizia Luperini-Enciso, Auteur ; Holda Purón-Zepeda, Auteur ; Lorena Pedraza-Segura, Auteur . - 2010 . - pp. 308–316. Industrial chemistry Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 49 N° 1 (Janvier 2010) . - pp. 308–316 Mots-clés : Optimal--Startup--Shutdown--Operating--Policies--Recombinant--Strain--Continuously--Stirred--Bioreactor Résumé : In this work dynamic optimal startup and shutdown policies were computed and validated in an experimental lab-scale continuous bioreactor. Using the theoretical optimal profile, a reduction in the startup time was achieved when compared to simple steplike changes in the manipulated variables. Therefore, the use of optimal startup policies led to raw material savings. To test the optimal startup policies, two operating points were selected. Experiments were run at these conditions to fit kinetic rate constants leading to a reliable model representation of the addressed biosystem. The practical implementation of theoretical optimization results is not a trivial task, and this is a major contribution of the present work. This is true especially for the optimal dynamic shutdown results that are not, up to our best knowledge, reported in the open literature. ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie901138p

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