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Quantitative study on polymorphic form in solution crystallization of clopidogrel hydrogen sulfate / Hye-Jin Kim in Industrial & engineering chemistry research, Vol. 48 N° 24 (Décembre 2009) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 48 N° 24 (Décembre 2009) . - pp. 11133–11139 Titre : Quantitative study on polymorphic form in solution crystallization of clopidogrel hydrogen sulfate Type de document : texte imprimé Auteurs : Hye-Jin Kim, Auteur ; Kwang-Joo Kim, Auteur Année de publication : 2010 Article en page(s) : pp. 11133–11139 Note générale : Industrial chemistry Langues : Anglais (eng) Mots-clés : Quantitative--Study--Polymorphic--Solution--Crystallization--Clopidogrel--Hydrogen--Sulfate Résumé : The concentration of polymorphs was explored by the ultrasonic measuring technique during crystallization in solution. The polymorphic form of the crystallized solid, the concentration of the solution, and the transformation of polymorphs were found by the ultrasonic measuring technique. The ultrasonic velocity calibrated at known solid and liquid concentrations has been applied to determine quantitatively the polymorphic compositions for various process conditions. Additionally, it can be used to estimate the solute concentration and the supersaturation of solution during the transformation of polymorphs. Multivariate data analysis from the ultrasonic measuring technique was used to determine the kinetics of polymorph transformation and to simulate the transformation process. It was found that the transformation of polymorphs occurred simultaneously with crystallization of a polymorph in the solution. ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie900715w [article] Quantitative study on polymorphic form in solution crystallization of clopidogrel hydrogen sulfate [texte imprimé] / Hye-Jin Kim, Auteur ; Kwang-Joo Kim, Auteur . - 2010 . - pp. 11133–11139. Industrial chemistry Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 48 N° 24 (Décembre 2009) . - pp. 11133–11139 Mots-clés : Quantitative--Study--Polymorphic--Solution--Crystallization--Clopidogrel--Hydrogen--Sulfate Résumé : The concentration of polymorphs was explored by the ultrasonic measuring technique during crystallization in solution. The polymorphic form of the crystallized solid, the concentration of the solution, and the transformation of polymorphs were found by the ultrasonic measuring technique. The ultrasonic velocity calibrated at known solid and liquid concentrations has been applied to determine quantitatively the polymorphic compositions for various process conditions. Additionally, it can be used to estimate the solute concentration and the supersaturation of solution during the transformation of polymorphs. Multivariate data analysis from the ultrasonic measuring technique was used to determine the kinetics of polymorph transformation and to simulate the transformation process. It was found that the transformation of polymorphs occurred simultaneously with crystallization of a polymorph in the solution. ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie900715w

Quantitative study on polymorphic form in solution crystallization of clopidogrel hydrogen sulfate / Hye-Jin Kim in Industrial & engineering chemistry research, Vol. 48 N° 24 (Décembre 2009) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 48 N° 24 (Décembre 2009) . - pp. 11133–11139 Titre : Quantitative study on polymorphic form in solution crystallization of clopidogrel hydrogen sulfate Type de document : texte imprimé Auteurs : Hye-Jin Kim, Auteur ; Kwang-Joo Kim, Auteur Année de publication : 2010 Article en page(s) : pp. 11133–11139 Note générale : Chemical engineering Langues : Anglais (eng) Mots-clés : Polymorphs  Crystallized  solid  Ultrasonic  velocity Résumé : The concentration of polymorphs was explored by the ultrasonic measuring technique during crystallization in solution. The polymorphic form of the crystallized solid, the concentration of the solution, and the transformation of polymorphs were found by the ultrasonic measuring technique. The ultrasonic velocity calibrated at known solid and liquid concentrations has been applied to determine quantitatively the polymorphic compositions for various process conditions. Additionally, it can be used to estimate the solute concentration and the supersaturation of solution during the transformation of polymorphs. Multivariate data analysis from the ultrasonic measuring technique was used to determine the kinetics of polymorph transformation and to simulate the transformation process. It was found that the transformation of polymorphs occurred simultaneously with crystallization of a polymorph in the solution. En ligne : http://pubs.acs.org/doi/abs/10.1021/ie900715w [article] Quantitative study on polymorphic form in solution crystallization of clopidogrel hydrogen sulfate [texte imprimé] / Hye-Jin Kim, Auteur ; Kwang-Joo Kim, Auteur . - 2010 . - pp. 11133–11139. Chemical engineering Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 48 N° 24 (Décembre 2009) . - pp. 11133–11139 Mots-clés : Polymorphs  Crystallized  solid  Ultrasonic  velocity Résumé : The concentration of polymorphs was explored by the ultrasonic measuring technique during crystallization in solution. The polymorphic form of the crystallized solid, the concentration of the solution, and the transformation of polymorphs were found by the ultrasonic measuring technique. The ultrasonic velocity calibrated at known solid and liquid concentrations has been applied to determine quantitatively the polymorphic compositions for various process conditions. Additionally, it can be used to estimate the solute concentration and the supersaturation of solution during the transformation of polymorphs. Multivariate data analysis from the ultrasonic measuring technique was used to determine the kinetics of polymorph transformation and to simulate the transformation process. It was found that the transformation of polymorphs occurred simultaneously with crystallization of a polymorph in the solution. En ligne : http://pubs.acs.org/doi/abs/10.1021/ie900715w