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Precipitation and transformation of the three polymorphs of d-mannitol / Jeroen Cornel in Industrial & engineering chemistry research, Vol. 49 N° 12 (Juin 2010) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 49 N° 12 (Juin 2010) . - pp. 5854–5862 Titre : Precipitation and transformation of the three polymorphs of d-mannitol Type de document : texte imprimé Auteurs : Jeroen Cornel, Auteur ; Piran Kidambi, Auteur ; Mazzotti, Marco, Auteur Année de publication : 2010 Article en page(s) : pp. 5854–5862 Note générale : Chemical engineering Langues : Anglais (eng) Mots-clés : d-mannitol’s  three  polymorphs  Thermodynamic  aspects  kinetic  aspects  Solid-state  forms Résumé : In this work, the thermodynamic and kinetic aspects of d-mannitol’s three polymorphs and their transformations are addressed. Scalable and reproducible syntheses of the solid-state forms are presented, and a mathematical model to describe a three-polymorph transformation is discussed in detail. It is shown that, for certain initial solute concentrations, the α polymorph nucleates first and then transforms through the β form to the γ form. Moreover, a supersaturation threshold to nucleate the α form has been observed, and below this threshold value, the γ form nucleates. A theoretical analysis demonstrates that this behavior can be predicted and that this experimental observation is physically sound. En ligne : http://pubs.acs.org/doi/abs/10.1021/ie9019616 [article] Precipitation and transformation of the three polymorphs of d-mannitol [texte imprimé] / Jeroen Cornel, Auteur ; Piran Kidambi, Auteur ; Mazzotti, Marco, Auteur . - 2010 . - pp. 5854–5862. Chemical engineering Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 49 N° 12 (Juin 2010) . - pp. 5854–5862 Mots-clés : d-mannitol’s  three  polymorphs  Thermodynamic  aspects  kinetic  aspects  Solid-state  forms Résumé : In this work, the thermodynamic and kinetic aspects of d-mannitol’s three polymorphs and their transformations are addressed. Scalable and reproducible syntheses of the solid-state forms are presented, and a mathematical model to describe a three-polymorph transformation is discussed in detail. It is shown that, for certain initial solute concentrations, the α polymorph nucleates first and then transforms through the β form to the γ form. Moreover, a supersaturation threshold to nucleate the α form has been observed, and below this threshold value, the γ form nucleates. A theoretical analysis demonstrates that this behavior can be predicted and that this experimental observation is physically sound. En ligne : http://pubs.acs.org/doi/abs/10.1021/ie9019616