On the selection of limiting hydrodynamic conditions for the supercritical antisolvent (SAS) process / Alvaro Tenorio in Industrial & engineering chemistry research, Vol. 48 N° 20 (Octobre 2009)  

Public ISBD [article]  inIndustrial & engineering chemistry research > Vol. 48 N° 20 (Octobre 2009) . - pp. 9224–9232 Titre : On the selection of limiting hydrodynamic conditions for the supercritical antisolvent (SAS) process Type de document : texte imprimé Auteurs : Alvaro Tenorio, Auteur ; Philip Jaeger, Auteur ; Maria D. Gordillo, Auteur Année de publication : 2010 Article en page(s) : pp. 9224–9232 Note générale : Chemical engineering Langues : Anglais (eng) Mots-clés : Supercritical antisolvent technique Active pharmaceutical compounds Thermodynamic properties Résumé : The Supercritical AntiSolvent (SAS) technique (which is also referred to as ASES, PCA, or SEDS in the literature) is a promising means of overcoming the low bioavailability found in some active pharmaceutical compounds (APIs). By determining the thermodynamic properties of the phases involved in the process, and applying empirical equations (operations with dimensionless numbers), it has been possible to estimate the different disintegration regimes of the jet when an N-methyl-pyrrolidone (NMP)−ampicillin solution is injected into the CO2-pressurized chamber under pressure (P), temperature (T), and flow rate (QL) conditions in the following ranges: P = 80−180 bar, T = 308−328 K, QL = 1−5 mL/min. The application of the empirical hydrodynamics model highlights the existence of significant mechanisms that stabilize the liquid jet, and it shows that there are limiting hydrodynamic conditions that must be overcome to direct the process toward the formation of uniform spherical nanoparticles and the achievement of higher yields. En ligne : http://pubs.acs.org/doi/abs/10.1021/ie801940p [article] On the selection of limiting hydrodynamic conditions for the supercritical antisolvent (SAS) process [texte imprimé] / Alvaro Tenorio, Auteur ; Philip Jaeger, Auteur ; Maria D. Gordillo, Auteur . - 2010 . - pp. 9224–9232. Chemical engineering Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 48 N° 20 (Octobre 2009) . - pp. 9224–9232 Mots-clés : Supercritical antisolvent technique Active pharmaceutical compounds Thermodynamic properties Résumé : The Supercritical AntiSolvent (SAS) technique (which is also referred to as ASES, PCA, or SEDS in the literature) is a promising means of overcoming the low bioavailability found in some active pharmaceutical compounds (APIs). By determining the thermodynamic properties of the phases involved in the process, and applying empirical equations (operations with dimensionless numbers), it has been possible to estimate the different disintegration regimes of the jet when an N-methyl-pyrrolidone (NMP)−ampicillin solution is injected into the CO2-pressurized chamber under pressure (P), temperature (T), and flow rate (QL) conditions in the following ranges: P = 80−180 bar, T = 308−328 K, QL = 1−5 mL/min. The application of the empirical hydrodynamics model highlights the existence of significant mechanisms that stabilize the liquid jet, and it shows that there are limiting hydrodynamic conditions that must be overcome to direct the process toward the formation of uniform spherical nanoparticles and the achievement of higher yields. En ligne : http://pubs.acs.org/doi/abs/10.1021/ie801940p

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