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Nanonization of megestrol acetate by liquid precipitation / Zhi-Bing Zhang in Industrial & engineering chemistry research, Vol. 48 N° 18 (Septembre 2009) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 48 N° 18 (Septembre 2009) . - pp. 8493–8499 Titre : Nanonization of megestrol acetate by liquid precipitation Type de document : texte imprimé Auteurs : Zhi-Bing Zhang, Auteur ; Zhi-Gang Shen, Auteur ; Jie - Xin Wang, Auteur Année de publication : 2010 Article en page(s) : pp. 8493–8499 Note générale : Chemical engineering Langues : Anglais (eng) Mots-clés : Megestrol  acetate  nanoparticles  Liquid  precipitation  technique Résumé : The purpose of this study was to prepare megestrol acetate (MA) nanoparticles via a liquid precipitation technique. Several experimental parameters, such as the stabilizer combination, the volume ratio of antisolvent to drug solution, the temperature, the stirring speed, and the drying method were investigated. The as-prepared MA particles had a mean size of 208 nm, and 90% of the particles were distributed in the range of 100−300 nm, whereas the raw MA had a mean particle size of about 3.02 μm, ranging widely from 0.2 μm to 30 μm. X-ray diffraction (XRD), differential scanning calorimetry (DSC), and Fourier transform infrared (FTIR) analysis indicated that MA nanoparticles exhibited decreased crystallinity and unchanged chemical group structure after precipitation. The freeze-dried MA nanoparticles exhibited improved wettability as demonstrated by the contact angle measurement result proving that particles were covered by a hydrophilic layer. In dissolution rate tests, the nanoparticles achieved 100% drug dissolution within 5 min, while the raw MA did not dissolve completely after 120 min, suggesting that the dissolution property of MA nanoparticles was significantly enhanced. En ligne : http://pubs.acs.org/doi/abs/10.1021/ie900944y [article] Nanonization of megestrol acetate by liquid precipitation [texte imprimé] / Zhi-Bing Zhang, Auteur ; Zhi-Gang Shen, Auteur ; Jie - Xin Wang, Auteur . - 2010 . - pp. 8493–8499. Chemical engineering Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 48 N° 18 (Septembre 2009) . - pp. 8493–8499 Mots-clés : Megestrol  acetate  nanoparticles  Liquid  precipitation  technique Résumé : The purpose of this study was to prepare megestrol acetate (MA) nanoparticles via a liquid precipitation technique. Several experimental parameters, such as the stabilizer combination, the volume ratio of antisolvent to drug solution, the temperature, the stirring speed, and the drying method were investigated. The as-prepared MA particles had a mean size of 208 nm, and 90% of the particles were distributed in the range of 100−300 nm, whereas the raw MA had a mean particle size of about 3.02 μm, ranging widely from 0.2 μm to 30 μm. X-ray diffraction (XRD), differential scanning calorimetry (DSC), and Fourier transform infrared (FTIR) analysis indicated that MA nanoparticles exhibited decreased crystallinity and unchanged chemical group structure after precipitation. The freeze-dried MA nanoparticles exhibited improved wettability as demonstrated by the contact angle measurement result proving that particles were covered by a hydrophilic layer. In dissolution rate tests, the nanoparticles achieved 100% drug dissolution within 5 min, while the raw MA did not dissolve completely after 120 min, suggesting that the dissolution property of MA nanoparticles was significantly enhanced. En ligne : http://pubs.acs.org/doi/abs/10.1021/ie900944y