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A rationale for monod's biochemical growth kinetics / Doraiswami Ramkrishna in Industrial & engineering chemistry research, Vol. 47 N° 23 (Décembre 2008) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 47 N° 23 (Décembre 2008) . - p. 9090–9098 Titre : A rationale for monod's biochemical growth kinetics Type de document : texte imprimé Auteurs : Doraiswami Ramkrishna, Auteur ; Hyun-Seob Song, Auteur Année de publication : 2009 Article en page(s) : p. 9090–9098 Note générale : Chemistry engineering Langues : Anglais (eng) Mots-clés : Biochemical  Growth  Kinetics Résumé : A rationale is presented for Monod′s biochemical kinetics which has hitherto been viewed as purely empirical. It is shown here that this expression, which continues to be used by modelers of biochemical processes, has indeed an origin that relates to the detailed treatment of metabolism. This rationale originates from the resolution of the metabolic network into so-called elementary modes and assumes steady state for every metabolite in each elementary mode. En ligne : http://pubs.acs.org/doi/abs/10.1021/ie800905d [article] A rationale for monod's biochemical growth kinetics [texte imprimé] / Doraiswami Ramkrishna, Auteur ; Hyun-Seob Song, Auteur . - 2009 . - p. 9090–9098. Chemistry engineering Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 47 N° 23 (Décembre 2008) . - p. 9090–9098 Mots-clés : Biochemical  Growth  Kinetics Résumé : A rationale is presented for Monod′s biochemical kinetics which has hitherto been viewed as purely empirical. It is shown here that this expression, which continues to be used by modelers of biochemical processes, has indeed an origin that relates to the detailed treatment of metabolism. This rationale originates from the resolution of the metabolic network into so-called elementary modes and assumes steady state for every metabolite in each elementary mode. En ligne : http://pubs.acs.org/doi/abs/10.1021/ie800905d

When is the quasi-steady-state approximation admissible in metabolic modeling? when admissible, what models are desirable? / Hyun-Seob Song in Industrial & engineering chemistry research, Vol. 48 N° 17 (Septembre 2009) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 48 N° 17 (Septembre 2009) . - pp. 7976–7985 Titre : When is the quasi-steady-state approximation admissible in metabolic modeling? when admissible, what models are desirable? Type de document : texte imprimé Auteurs : Hyun-Seob Song, Auteur ; Doraiswami Ramkrishna, Auteur Année de publication : 2009 Article en page(s) : pp. 7976–7985 Note générale : Chemical engineering Langues : Anglais (eng) Mots-clés : Quasi-steady-state  approximation  Metabolic  modeling Résumé : A strategy is presented for scrutiny of the quasi-steady-state (QSS) approximation in metabolic modeling that involves tracking dynamic data on extracellular products in so-called flux, as well as yield vector spaces when the substrate uptake flux is perturbed sinusoidally about some average value with specified frequency and amplitude. Criteria accrue for the diagnosis of any violation (and its extent) of the QSS approximation and are applied to data produced by simulations from models free from the QSS approximation. It is shown that, even when the assumption is admissible, the choice of the appropriate QSS model depends on the frequency and amplitude of the perturbation. Three different QSS models in the literature, viz., dynamic flux balance analysis, the macroscopic bioreaction model, and the hybrid cybernetic model, are evaluated, and circumstances are identified when one or more of the QSS models might be valid, as well as when none of them are. En ligne : http://pubs.acs.org/doi/abs/10.1021/ie900075f [article] When is the quasi-steady-state approximation admissible in metabolic modeling? when admissible, what models are desirable? [texte imprimé] / Hyun-Seob Song, Auteur ; Doraiswami Ramkrishna, Auteur . - 2009 . - pp. 7976–7985. Chemical engineering Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 48 N° 17 (Septembre 2009) . - pp. 7976–7985 Mots-clés : Quasi-steady-state  approximation  Metabolic  modeling Résumé : A strategy is presented for scrutiny of the quasi-steady-state (QSS) approximation in metabolic modeling that involves tracking dynamic data on extracellular products in so-called flux, as well as yield vector spaces when the substrate uptake flux is perturbed sinusoidally about some average value with specified frequency and amplitude. Criteria accrue for the diagnosis of any violation (and its extent) of the QSS approximation and are applied to data produced by simulations from models free from the QSS approximation. It is shown that, even when the assumption is admissible, the choice of the appropriate QSS model depends on the frequency and amplitude of the perturbation. Three different QSS models in the literature, viz., dynamic flux balance analysis, the macroscopic bioreaction model, and the hybrid cybernetic model, are evaluated, and circumstances are identified when one or more of the QSS models might be valid, as well as when none of them are. En ligne : http://pubs.acs.org/doi/abs/10.1021/ie900075f