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Hydrotropic extraction process for recovery of forskolin from coleus forskohlii roots / Sanjay P. Mishra in Industrial & engineering chemistry research, Vol. 48 N° 17 (Septembre 2009)

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 48 N° 17 (Septembre 2009) . - pp. 8083–8090 Titre : Hydrotropic extraction process for recovery of forskolin from coleus forskohlii roots Type de document : texte imprimé Auteurs : Sanjay P. Mishra, Auteur ; Vilas G. Gaikar, Auteur Année de publication : 2009 Article en page(s) : pp. 8083–8090 Note générale : Chemical engineering Langues : Anglais (eng) Mots-clés : Hydrotropic  solubilization  Forskolin  Coleus  forskohlii  root Résumé : A simple and rapid method based on hydrotropic solubilization is developed for isolation of forskolin from coleus forskohlii roots. The plant cells are permeabilized by aqueous hydrotrope solutions followed by extraction and solubilization of forskolin into the hydrotrope solutions of alkyl benzene sulfonates and carboxylates. The solubility of forskolin is increased by 350 times in the hydrotropic solutions and it is possible to recover 85% pure forskolin from the hydrotropic solutions by simple dilution with water. The purity of the recovered forskolin decreased from 85% to 70% on decreasing particle size of the roots. Nearly 80% of the forskolin having 50% purity was recovered from the coleus roots using 2.0 mol/dm3 aqueous sodium cumene sulfonate (Na−CS) solutions at 363 K. Na−CS showed the most efficient solubilization of forskolin from the Coleus roots among all the other hydrotropes. [article] Hydrotropic extraction process for recovery of forskolin from coleus forskohlii roots [texte imprimé] / Sanjay P. Mishra, Auteur ; Vilas G. Gaikar, Auteur . - 2009 . - pp. 8083–8090. Chemical engineering Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 48 N° 17 (Septembre 2009) . - pp. 8083–8090 Mots-clés : Hydrotropic  solubilization  Forskolin  Coleus  forskohlii  root Résumé : A simple and rapid method based on hydrotropic solubilization is developed for isolation of forskolin from coleus forskohlii roots. The plant cells are permeabilized by aqueous hydrotrope solutions followed by extraction and solubilization of forskolin into the hydrotrope solutions of alkyl benzene sulfonates and carboxylates. The solubility of forskolin is increased by 350 times in the hydrotropic solutions and it is possible to recover 85% pure forskolin from the hydrotropic solutions by simple dilution with water. The purity of the recovered forskolin decreased from 85% to 70% on decreasing particle size of the roots. Nearly 80% of the forskolin having 50% purity was recovered from the coleus roots using 2.0 mol/dm3 aqueous sodium cumene sulfonate (Na−CS) solutions at 363 K. Na−CS showed the most efficient solubilization of forskolin from the Coleus roots among all the other hydrotropes.