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Comparison of recycle chromatography and simulated moving bed for pseudobinary separations / Ju Weon Lee in Industrial & engineering chemistry research, Vol. 48 N° 16 (Août 2009) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 48 N° 16 (Août 2009) . - pp. 7724–7732 Titre : Comparison of recycle chromatography and simulated moving bed for pseudobinary separations Type de document : texte imprimé Auteurs : Ju Weon Lee, Auteur ; Phillip C. Wankat, Auteur Année de publication : 2009 Article en page(s) : pp. 7724–7732 Note générale : Chemical engineering Langues : Anglais (eng) Mots-clés : Simulated  moving  bed  (SMB)  process  Pseudobinary  separation  Binary  separation Résumé : The simulated moving bed (SMB) process has been extensively used in industrial separations for binary and pseudobinary separations. The SMB has been reported to have higher productivity and requires less desorbent than batch chromatography; however, in pseudobinary separations these advantages are dependent on the difference of adsorption behaviors of the nontarget components. In this research, the performance of batch chromatography with a single recycle stream was compared to SMB processes for pseudobinary separations of ternary nucleosides, a model system with competitive Langmuir isotherms. To compare the performances of SMB and recycle batch chromatography, detailed dynamic simulations of each process were performed with optimized operating conditions. The desorbent to feed ratio, D/F, of recycle chromatography was at least 2 times smaller than that of a four-column SMB process for most retained solute separations. For one case of least retained solute separation (2′-deoxycytidine/2′-deoxythymidine/2′-deoxyadenosine), minimum D/F of the four-column SMB process is approximately 15 times larger than that of recycle chromatography. The maximum productivity of recycle chromatography is 1.5−2 times larger than that of the four-column SMB process. When eight columns are used in the four-zone SMB process (two columns per zone), the performance (productivity, D/F, and pressure drop) is improved compared to the four-column SMB. The eight-column SMB has higher maximum productivity, and at the same productivity, it also has lower D/F and lower pressure drop compared to recycle chromatography. However, the recycle chromatography system is simpler and has fewer columns. En ligne : http://pubs.acs.org/doi/abs/10.1021/ie900092y [article] Comparison of recycle chromatography and simulated moving bed for pseudobinary separations [texte imprimé] / Ju Weon Lee, Auteur ; Phillip C. Wankat, Auteur . - 2009 . - pp. 7724–7732. Chemical engineering Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 48 N° 16 (Août 2009) . - pp. 7724–7732 Mots-clés : Simulated  moving  bed  (SMB)  process  Pseudobinary  separation  Binary  separation Résumé : The simulated moving bed (SMB) process has been extensively used in industrial separations for binary and pseudobinary separations. The SMB has been reported to have higher productivity and requires less desorbent than batch chromatography; however, in pseudobinary separations these advantages are dependent on the difference of adsorption behaviors of the nontarget components. In this research, the performance of batch chromatography with a single recycle stream was compared to SMB processes for pseudobinary separations of ternary nucleosides, a model system with competitive Langmuir isotherms. To compare the performances of SMB and recycle batch chromatography, detailed dynamic simulations of each process were performed with optimized operating conditions. The desorbent to feed ratio, D/F, of recycle chromatography was at least 2 times smaller than that of a four-column SMB process for most retained solute separations. For one case of least retained solute separation (2′-deoxycytidine/2′-deoxythymidine/2′-deoxyadenosine), minimum D/F of the four-column SMB process is approximately 15 times larger than that of recycle chromatography. The maximum productivity of recycle chromatography is 1.5−2 times larger than that of the four-column SMB process. When eight columns are used in the four-zone SMB process (two columns per zone), the performance (productivity, D/F, and pressure drop) is improved compared to the four-column SMB. The eight-column SMB has higher maximum productivity, and at the same productivity, it also has lower D/F and lower pressure drop compared to recycle chromatography. However, the recycle chromatography system is simpler and has fewer columns. En ligne : http://pubs.acs.org/doi/abs/10.1021/ie900092y

Optimized design of recycle chromatography for separation of a single component from a ternary mixture / Ju Weon Lee in Industrial & engineering chemistry research, Vol. 47 N° 23 (Décembre 2008) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 47 N° 23 (Décembre 2008) . - p. 9601–9610 Titre : Optimized design of recycle chromatography for separation of a single component from a ternary mixture Type de document : texte imprimé Auteurs : Ju Weon Lee, Auteur ; Phillip C. Wankat, Auteur Année de publication : 2009 Article en page(s) : p. 9601–9610 Note générale : Chemistry engineering Langues : Anglais (eng) Mots-clés : Optimized  design  Chromatography  Ternary  mixture Résumé : Recycle chromatographic systems were designed to isolate one component from a ternary mixture. Since the concentrations of the dilute ternary mixtures studied (phenols, amino acids, and benzenes) were all in the linear range of isotherms, the Lapidus−Amundson equation was used to predict the broadening of elution bands caused by axial dispersion and mass-transfer resistance. Optimum operating conditions were designed to isolate the target solutes with over 99% purity and yield. Compared to complete ternary separation, recycle chromatography for separation of a single component required significantly less solvent and had higher productivity. For the amino acid system the optimum column length and mobile-phase velocity which had maximum productivity were determined with different sizes of adsorbent particle. When large particles were used, longer columns and faster mobile-phase velocities were needed to obtain maximum productivity as compared with small particle sizes. En ligne : http://pubs.acs.org/doi/abs/10.1021/ie800583p [article] Optimized design of recycle chromatography for separation of a single component from a ternary mixture [texte imprimé] / Ju Weon Lee, Auteur ; Phillip C. Wankat, Auteur . - 2009 . - p. 9601–9610. Chemistry engineering Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 47 N° 23 (Décembre 2008) . - p. 9601–9610 Mots-clés : Optimized  design  Chromatography  Ternary  mixture Résumé : Recycle chromatographic systems were designed to isolate one component from a ternary mixture. Since the concentrations of the dilute ternary mixtures studied (phenols, amino acids, and benzenes) were all in the linear range of isotherms, the Lapidus−Amundson equation was used to predict the broadening of elution bands caused by axial dispersion and mass-transfer resistance. Optimum operating conditions were designed to isolate the target solutes with over 99% purity and yield. Compared to complete ternary separation, recycle chromatography for separation of a single component required significantly less solvent and had higher productivity. For the amino acid system the optimum column length and mobile-phase velocity which had maximum productivity were determined with different sizes of adsorbent particle. When large particles were used, longer columns and faster mobile-phase velocities were needed to obtain maximum productivity as compared with small particle sizes. En ligne : http://pubs.acs.org/doi/abs/10.1021/ie800583p