Article : texte imprimé

Production of (S)-1-benzyl-3-diazo-2-oxopropylcarbamic acid tert-butyl ester, a diazoketone pharmaceutical intermediate, employing a small scale continuous reactor

Pamela Pollet, Auteur ; Elizabeth D. Cope, Auteur ; Michelle K. Kassner, Auteur |

Dans Industrial & engineering chemistry research (Vol. 48 N° 15, Août 2009)

N-Boc-(1S)-benzylhydroxy-3-chloropropylamine (6) is a precursor to pharmaceutically active compounds that act as human immunodeficiency virus (HIV) protease inhibitors. It is currently being produced via a batch process which includes a homologa[...]

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