Practical approach to design and implementation of a control algorithm in an artificial pancreatic beta cell / Matthew W. Percival in Industrial & engineering chemistry research, Vol. 48 N° 13 (Juillet 2009)  

Public ISBD [article]  inIndustrial & engineering chemistry research > Vol. 48 N° 13 (Juillet 2009) . - pp. 6059–6067 Titre : Practical approach to design and implementation of a control algorithm in an artificial pancreatic beta cell Type de document : texte imprimé Auteurs : Matthew W. Percival, Auteur ; Dassau Eyal, Auteur ; Howard Zisser, Auteur Année de publication : 2009 Article en page(s) : pp. 6059–6067 Note générale : Chemical engineering Langues : Anglais (eng) Mots-clés : Artificial pancreatic beta cell Control algorithm Glucose-insulin kinetics Hardware-in-the-loop implementation Résumé : The rate limiting bottleneck in the development of an artificial pancreatic beta cell is currently the control algorithm used to make insulin dosing decisions. In this paper, a solution for the rapid development of a personalized control algorithm was proposed and the methodology was tested on the pilot scale using a physiological model of glucose−insulin kinetics and a hardware-in-the-loop (HIL) implementation of an artificial pancreatic beta cell. A model-based controller was developed from the identification tests and was augmented with advanced control strategies. The resulting controller improved glycemia from the open-loop case with no hypoglycemic events and a reduction in time spent hyperglycemic. Robustness issues were addressed with a 50% mismatch in insulin sensitivity from model to plant. The HIL platform provided insight into the effects of sensor drift and practicalities of continuous insulin delivery based on glucose sensor feedback. En ligne : http://pubs.acs.org/doi/abs/10.1021/ie801432u [article] Practical approach to design and implementation of a control algorithm in an artificial pancreatic beta cell [texte imprimé] / Matthew W. Percival, Auteur ; Dassau Eyal, Auteur ; Howard Zisser, Auteur . - 2009 . - pp. 6059–6067. Chemical engineering Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 48 N° 13 (Juillet 2009) . - pp. 6059–6067 Mots-clés : Artificial pancreatic beta cell Control algorithm Glucose-insulin kinetics Hardware-in-the-loop implementation Résumé : The rate limiting bottleneck in the development of an artificial pancreatic beta cell is currently the control algorithm used to make insulin dosing decisions. In this paper, a solution for the rapid development of a personalized control algorithm was proposed and the methodology was tested on the pilot scale using a physiological model of glucose−insulin kinetics and a hardware-in-the-loop (HIL) implementation of an artificial pancreatic beta cell. A model-based controller was developed from the identification tests and was augmented with advanced control strategies. The resulting controller improved glycemia from the open-loop case with no hypoglycemic events and a reduction in time spent hyperglycemic. Robustness issues were addressed with a 50% mismatch in insulin sensitivity from model to plant. The HIL platform provided insight into the effects of sensor drift and practicalities of continuous insulin delivery based on glucose sensor feedback. En ligne : http://pubs.acs.org/doi/abs/10.1021/ie801432u

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